MM4-PD-08 Introduction: During autumn 2002, a large eruption of Mount Etna (Sicily, Italy) occurred. Ash fell over the city of Catania (about 400,000 inhabitants) and the resident population experienced a public health emergency for several days. Unusually high levels of suspended particulate matter, PM10, (over 100–200 μg/m3) were recorded. The local population was alerted and the Department of Civil Protection issued emergency preventive measures. The aim of the study was to evaluate the acute health effects on mortality and hospital admissions in the area around the volcano. Methods: A time-series approach was adopted for the analysis of data (time unit = day). Health outcomes during the eruption period were compared with those from the same period of the previous year (1-day shift forward to take into account the day of the week effect). Relative risks (RR) and their 95% confidence intervals (CI) were computed. Poisson regression was used to evaluate the association between daily average PM10 and daily counts of hospital admissions for cardiovascular diseases. Results: The study observed a total of 106 days of observation for each year, corresponding to 59 days of eruption and 47 days of noneruption. No effects on overall and cause-specific mortality were observed during the eruption period. Mortality for respiratory diseases (RR = 0.46; 95% CI = 0.26–0.82) as well as hospital admissions for trauma (RR = 0.77; 95% CI = 0.67–0.88) was significantly decreased. Increases in hospital admissions for cardiovascular diseases were observed: ischemic heart diseases, RR = 1.31; 95% CI = 1.10–1.56; myocardial infarction, RR = 1.34; 95% CI = 1.02–1.76, and cerebrovascular diseases, RR = 1.24; 95% CI = 1.05–1.47. The excesses were stronger among the elderly. Daily admissions for cardiovascular diseases were not associated with PM10 levels. Discussion and Conclusions: The effects of the eruption were limited to a temporary increase in cardiovascular morbidity, especially among the elderly, possibly as a consequence of in acute stress. This phenomenon has been reported following other natural disasters. The decrease in mortality for respiratory diseases and the decrease in hospital admissions for trauma were probably a result of the precautionary measures taken during the emergency period. When planning public health measures during natural disasters, special attention should be given to risk communication.