In the Central Andes, large Plinian eruptions (Volcanic Explosivity Index ≥ 5) occur at a relatively high frequency, i.e. average one every 2000 to 4000 years over the past 50,000 years in Peru. Such recurring explosive activity represents a significant challenge for regions typically hosting several million people (e.g. Southern Peru, Western Bolivia and Northern Chile). With VEI 6, the 1600 CE Huaynaputina eruption is considered the largest historical eruption in South America. We have re-examined the first Plinian phase of this eruption in order to better assess critical eruption source parameters (i.e. erupted volume, plume height, mass eruption rate, eruption duration).The revised bulk volume of the tephra-fall deposit associated with the Plinian phase is approximately 13–14 km3, almost twice the previous estimate (7–8 km3 within the 1 cm isopach) based on methods including power law, Weibull function and Bayesian linear regression. Tephra was dispersed by strong winds to the WNW as far as 400 km on Peruvian territory and then in the Pacific Ocean. Seven villages were buried, killing ~ 1500 people. The revised plume height estimate, 32.2 ± 2.5 km, is consistent with the early estimations. As a result, the Huaynaputina 1600 CE first eruption phase lies in the upper part of the Plinian field close to the ultra-Plinian transition, making this event one of the largest in the past millennium which coincides with results from recent studies on palaeoclimatic impacts.