The optimization of supply chain management (SCM) is crucial for enhancing efficiency and reducing costs in manufacturing industries. This study employs a qualitative research approach to explore various strategies for SCM optimization. Data were collected through semi-structured interviews with SCM experts, focus groups with key stakeholders, and an extensive review of secondary sources. The analysis reveals that the integration of information technology (IT), including ERP systems, supply chain management software, cloud computing, and the Internet of Things (IoT), significantly enhances supply chain visibility and coordination, leading to improved decision-making and reduced lead times. Additionally, lean manufacturing and Just-In-Time (JIT) practices are found to be effective in minimizing waste, optimizing inventory levels, and aligning production schedules with market demand, thereby reducing costs and increasing operational efficiency. Strategic supplier partnerships and collaborations play a vital role in achieving synchronization across the supply chain, improving quality, and managing risks. The adoption of sustainability and green supply chain management (GSCM) practices is also highlighted as a key driver for cost reduction and efficiency improvement. These practices not only enhance environmental performance but also drive innovation and provide a competitive advantage. However, the study acknowledges the challenges associated with implementing these strategies, including high initial costs, the need for skilled personnel, and the complexity of managing multiple supplier relationships. Despite these challenges, the findings suggest that a holistic approach to SCM optimization, integrating traditional methods with cutting-edge technologies, can significantly enhance supply chain performance. This research provides valuable insights for both academia and industry practitioners, offering practical guidelines for implementing effective SCM strategies. By adopting these strategies, manufacturers can build resilient and adaptive supply chains capable of meeting the evolving demands of the global market, ensuring sustainable growth and competitiveness.