ERP Study Research Articles

Early visual modulation and selection predict saccadic timing during visual search: An ERP study.

Saccadic eye movements, a critical aspect of real-world visual behavior, are preceded by an initial accumulation of visual information followed by the selection of a single location to move one's eyes. However, it is currently unclear how each of these stages uniquely affects saccadic timing. In this study, participants searched for a contour integration target while EEG was used to measure posterior cortical activity between search display onset and first saccade initiation. The goal was to determine whether saccade timing could be attributed to differences in early ERP amplitudes, with the P1 reflecting the magnitude of early perceptual information accumulation and the N1 reflecting the strength of selection leading to the saccadic decision. EOG was used to measure saccade timing, and trials were divided into fast, middle, and slow bins. The N1 response was smallest in the slow saccade tertile, relative to both the fast and middle tertiles, suggesting weak selection. In contrast, the P1 response was largest for this same slow saccadic tertile relative to the middle saccadic tertile, suggesting vigorous information accumulation. Therefore, delays in saccadic behavior may occur when the visual system is overwhelmed with visual input, thus increasing the time to reach a saccadic decision. These findings reconcile models of eye movement behavior which often prioritize either the impact of information accrual or selection, rather than regarding both as an integrated whole.

The early visual processing of faces in a basic classification task: An ERP study of spatial frequency, other-race and other species effect

ABSTRACT This study investigates the neural processing of other-race and other-species faces, using spatial frequencies (SFs) to probe into early visual processing mechanisms. We conducted a basic classification task to reveal fundamental aspects of facial processing without the complexity of higher-order recognition tasks. This approach utilized SFs set at low (LSF, 0.53 cycles per degree [cpd]), broadband (BB), and high (HSF, 2.1 cpd) SFs to examine their impact on the both P100 and N170 components of event-related potentials. Our findings revealed a significant latency difference in the N170 component under HSF conditions, indicating race-specific efficiency in processing fine details between Asian and Caucasian faces. Furthermore, N170 amplitudes were consistently larger for human than monkey faces, with this difference more pronounced in LSF and BB conditions. This finding indicates that the other-species effect in early visual processing is more pronounced in holistic processing (LSF and BB conditions) rather than in fine-detail processing.

An ERP-based comparison of gender representations elicited by generic masculine role nouns and the German gender star form

There is an ongoing debate about the linguistic gender forms that should be used to elicit fair mental representations of all genders. While most languages with grammatical gender traditionally use the masculine form to refer to people in a gender-independent way, numerous empirical studies have demonstrated that this form leads to a male bias in mental representations. In German, the so-called gender star form has been proposed as an alternative to the masculine form, aimed at better representing persons with nonmale gender identities. To provide empirical data on this claim, we compared the neural processing mechanisms elicited by the gender star form with those elicited by the generically intended masculine form during reference resolution. Participants in the present ERP study read sentence pairs in which a group of people was introduced with a role noun in one of the two gender forms and then revealed to be partly comprised of men or women. Following the masculine form, anaphoric references to women (vs. men) resulted in an increased ERP amplitude in the P600 range. In contrast, following the gender star form, the P600 amplitude was increased for references to men (vs. women), albeit in a slightly different spatio-temporal range. The present data thus indicate that the gender star form and the generically intended masculine form impose partially different demands on the syntactic operations performed by the brain during reference resolution but that, in the end, neither form elicits gender-balanced mental representations of men and women in German.

Unveiling the neural mechanisms of acute aerobic exercise on inhibitory control among young adults with obesity: Insights from an ERP study

Obesity has become a prominent public health concern worldwide and is associated with adverse cognitive function. Exercise, particularly aerobic exercise, is known to benefit for weight loss and cognitive function. However, whether acute aerobic exercise could yield benefits to obese individuals and the precise brain mechanisms of action remain poorly understood. The study aimed to investigate whether acute aerobic exercise could improve inhibitory control among obese individuals and what neuroelectric mechanisms are implicated. A 3 (session: control, low-intensity exercise, moderate-intensity exercise) × 2 (congruency: congruent, incongruent) within-subject design was conducted. 18 obese young male adults underwent three sessions of 30-min interventions in a counterbalanced order seperated by five days: moderate-intensity aerobic exercise (MIE), low-intensity aerobic exercise (LIE) and a control session (a sedentary period of seated rest). The Flanker task and EEG recordings (N2 and P3 amplitude) were investigated following exercise and the control treatment. Results showed that the N2 amplitude following MIE was larger than the control session, whereas a larger N2 and reduced congruent P3 amplitude was observed following MIE than LIE. However, no main effect of the session was found for reaction time and accuracy, but a significant main effect of congruency was observed. These findings suggest acute moderate-intensity aerobic exercise may modulate brain activity through enhanced recruitment of attentional resources for cognitive control and conflict monitoring in adults with obesity.

The role of personality in social interaction perception: an ERP and source imaging study.

Agreeableness, one of the five personality traits, is associated with socio-cognitive abilities. This study investigates how agreeableness impacts the perception of social interactions, while considering sex that might moderate this effect. Sixty-two young adults, preselected to ensure a wide range of agreeableness scores, underwent EEG recording while viewing images depicting real-world scenes of two people either engaged in a social interaction or acting independently. Behavioral results suggested a trend where higher agreeableness scores predicted better ability to detect social interactions primarily in males. ERP analysis showed that individuals with higher agreeableness exhibited stronger neural differentiation between social and non-social stimuli, observed in both females and males, and in the whole sample. This neural differentiation, occurring early in the processing timeline, was particularly extensive in males, and predictive of their performance. Three independent source analyses, conducted for the whole sample and for each sex, identified the engagement of right fronto-parietal regions for the ERP-agreeableness association. These findings enhance our understanding of how agreeableness shapes the neural mechanisms underlying social interaction detection and emphasize sex as an important factor in this dynamic. They also highlight the need for tailored approaches that consider personality traits and sex in clinical interventions targeting social impairments.

The modulation of reward expectancy on the processing of near-miss outcomes: An ERP study

A near-miss is a situation in which a gambler almost wins but falls short by a small margin, which motivates gambling by making it feel like success is within reach. Existing research has extensively investigated the influence of contextual information on near-miss outcome processing; however, the impact of reward expectancy has received limited attention thus far. To address this gap, we utilized the wheel of fortune task and event-related potential technique (ERP) to quantify the electrophysiological responses associated with gambling outcomes at different levels of reward expectancy. Behaviorally, near-miss outcomes elicited a greater occurrence of counterfactual thoughts, feelings of regret, and heightened anticipation of rewards for subsequent trials compared to full-miss outcomes. ERP findings indicated that in contrast to full-miss outcomes, near-miss outcomes diminished feedback-related negativities (FRNs) and amplified P300s when reward expectancy was low, but amplified FRNs and diminished P300s when reward expectancy was high. These findings provide valuable insights into the neural mechanisms underlying the processing of outcome proximity and reward expectancy.

Cardiorespiratory fitness, independent of APOE genotype, is associated with better neurocognitive function in older adults: An ERP study

This study assessed the association between cardiorespiratory fitness and carriage of the apolipoprotein-E ε4 (APOE ε4) alleles and cognitive function using behavioral and neuroelectric measures obtained from cognitively normal older adults. A total of 159 adults aged 50–70 years were categorized into four groups based on cardiorespiratory fitness (i.e., higher vs. lower fitness) and the APOE genotype status (i.e., APOE ε4 carrier vs. non-carrier). Neurocognitive functions were indexed using response time and accuracy measures from the Stroop task and averaged mean P3 amplitudes of event-related potentials obtained during task performance. A significant main effect of cardiorespiratory fitness (p = .01) and the Stroop congruency (p < .001), but not the APOE genotype status, with shorter response times for the higher fitness group than for the lower fitness group and for the congruent condition relative to the incongruent condition, were observed. Similar findings were also revealed, with larger averaged mean P3 amplitudes for the higher fitness group than those in the lower fitness group, and in the congruent condition than in the incongruent condition. These findings suggest that higher cardiorespiratory fitness is linked to better neurocognitive function, and the positive association is evident regardless of the APOE ε4 status and the cognitive domain assessed in cognitively normal older adults.

An ERP study on the role of instant purchasing group quantity in e-commerce live streaming: a social impact perspective

An ERP study on the role of instant purchasing group quantity in e-commerce live streaming: a social impact perspective

Does cognitive control mediate the relationship between peer presence and adolescent risk-taking? An ERP study.

Peer presence influences risk-taking behavior, particularly in adolescence. Based on the dual system model, this event-related potential study examined whether and how the presence of a peer displayed a preference for risky behavior would increase adolescents' risk-taking by disrupting their cognitive control processes in either emotional or non-emotional contexts. A sample of 106 adolescents (17-19 years of age) completed two Stoop tasks and a Balloon Analog Risk Task under three peer presence conditions. Results revealed that compared to other conditions, the presence of a risk-averse peer caused adolescents to make safer decisions through improving their conflict monitoring (more negative N200-diff), whereas a risk-preference peer's presence led adolescents to more risky decisions through disrupting their conflict resolution (more positive N450-diff) but they were only observed on the Emotional Stroop task. These findings suggest that different peer presence contexts could increase or decrease adolescents' risk-taking behaviors by influencing their cognitive control under an emotional context rather than in a non-emotional context.

Reward History and Statistical Learning Independently Impact Attention Search: An ERP Study.

Selection history is widely accepted as a vital source in attention control. Reward history indicates that a learned association captures attention even when the reward is no longer presented, while statistical learning indicates that a learned probability exerts its influence on attentional control (facilitation or inhibition). Existing research has shown that the effects of the reward history and statistical learning are additive, suggesting that these two components influence attention priority through different pathways. In the current study, leveraging the temporal resolution advantages of EEG, we explored whether these two components represent independent sources of attentional bias. The results revealed faster responses to the target at the high-probability location compared to low-probability locations. Both the target and distractor at high-probability locations elicited larger early Pd (50-150 ms) and Pd (150-250 ms) components. The reward distractor slowed the target search and elicited a larger N2pc (180-350 ms). Further, no interaction between statistical learning and the reward history was observed in RTs or N2pc. The different types of temporal progression in attention control indicate that statistical learning and the reward history independently modulate the attention priority map.

The enhancing effect of social reward on inhibitory control in smokers: Evidence from behaviour and ERP studies.

Prior research has revealed impaired inhibitory control as a pivotal factor contributing to smokers' struggle to control smoking impulses. However, few studies focus on enhancing smokers' inhibitory control. This study investigates the potential of social rewards to bolster inhibitory control among smokers and elucidates the underlying mechanisms. In Experiment 1, a reward-based Go/Nogo paradigm assessed error rates and reaction times for 30 smokers exposed to social reward and neutral feedback in distinct contexts (smoking-related and neutral). Experiment 2 used a modified paradigm, incorporating cognitive load manipulation, to investigate error rates, reaction times, N2, and P3 ERPs among 32 smokers facing social reward and neutral feedback under different cognitive loads (high and low). Smokers exhibit lower Nogo error rates with social reward feedback; higher error rates occur with smoking cues and high cognitive load; increased N2, P3 amplitudes under social reward versus neutral feedback; low cognitive load enhances P3 amplitude under social reward. Social reward improves smokers' inhibitory control, but this effect weakens with exposure to smoking cues; higher cognitive load further diminishes the enhancement of smokers' inhibitory control by social reward under smoking cues.

The interplay between the proposer's role model and moral behavior modulates proposal processing in the Ultimatum Game: An ERP study

Economic decision-making plays a paramount role in both individual and national interests. Individuals have fairness preferences in economic decision-making, but a proposer's moral-related information may affect fairness considerations. In prior ERP studies, researchers have suggested moral identity influences fairness preferences in the Ultimatum Game (UG), but there are discrepancies in the results. Furthermore, whether role models (individuals whom someone else looks to help decide suitable behaviors), who can modulate people's moral standards, can affect fairness concerns in UG is still understudied. To address the questions, we selected the moral-related statements by eliminating those with illegal information and employed the ERP technique to explore whether the interplay of the proposer's role model and moral-related behavior influenced fairness processing in the modified UG and the corresponding neural mechanisms. We mainly found that the aforementioned interaction effect on proposal considerations in UG could be mirrored in both rejection rates and P300 variations. The results demonstrate that the interaction between the proposer's role model and moral behavior can modulate fairness concerns in UG. Our current work provides new avenues for elucidating the time course of the influencing mechanism of fair distributions in complicated social environments.

Advancing the treatment of anxiety disorders in transition-age youth: a review of the therapeutic effects of unconscious exposure.

The real-world effectiveness of exposure-based therapies for youth depends on the willingness and ability of young people to tolerate confronting their fears, which can be experienced as highly aversive and create problems with treatment engagement and acceptance. Recently, neuroscientific research on the nonconscious basis of fear has been translated into novel exposure interventions that bypass conscious processing of feared stimuli and that thus do not cause phobic youth to experience distress. We present a review of these unconscious exposure interventions. A PRISMA-based search yielded 20 controlled experiments based on three paradigms that tested if fear-related responses could be reduced without conscious awareness in highly phobic, transition-age youth: 14 randomized controlled trials (RCTs), 5 fMRI studies (1 was also an RCT), 4 psychophysiological studies (3 were also RCTs), and 1 ERP study. We conducted meta-analyses of outcomes where feasible. Unconscious exposure interventions significantly (1) reduced avoidance behavior (range of Cohen's d = 0.51-0.95) and self-reported fear (d = 0.45-1.25) during in vivo exposure to the feared situation; (2) reduced neurobiological indicators of fear (d = 0.54-0.62) and concomitant physiological arousal (d = 0.55-0.64); (3) activated neural systems supporting fear regulation more strongly than visible exposure to the same stimuli (d = 1.2-1.5); (4) activated regions supporting fear regulation that mediated the reduction of avoidance behavior (d = 0.70); (5) evoked ERPs suggesting encoding of extinction memories (d = 2.13); and (6) had these effects without inducing autonomic arousal or subjective fear. Unconscious exposure interventions significantly reduce a variety of symptomatic behaviors with mostly moderate effect sizes in transition-age youth with specific phobias. fMRI and physiological findings establish a neurophysiological basis for this efficacy, and suggest it occurs through extinction learning. Unconscious exposure was well tolerated, entirely unassociated with drop out, and is highly scalable for clinical practice. However, a number of limitations must be addressed to assess potential clinical impacts, including combining unconscious exposure with exposure therapy to boost treatment acceptance and efficacy.

An ERP investigation of perceptual vs motoric iconicity in sign production

The type of form-meaning mapping for iconic signs can vary. For perceptually-iconic signs there is a correspondence between visual features of a referent (e.g., the beak of a bird) and the form of the sign (e.g., extended thumb and index finger at the mouth for the American Sign Language (ASL) sign BIRD). For motorically-iconic signs there is a correspondence between how an object is held/manipulated and the form of the sign (e.g., the ASL sign FLUTE depicts how a flute is played). Previous studies have found that iconic signs are retrieved faster in picture-naming tasks, but type of iconicity has not been manipulated. We conducted an ERP study in which deaf signers and a control group of English speakers named pictures that targeted perceptually-iconic, motorically-iconic, or non-iconic ASL signs. For signers (unlike the control group), naming latencies varied by iconicity type: perceptually-iconic < motorically-iconic < non-iconic signs. A reduction in the N400 amplitude was only found for the perceptually-iconic signs, compared to both non-iconic and motorically-iconic signs. No modulations of N400 amplitudes were observed for the control group. We suggest that this pattern of results arises because pictures eliciting perceptually-iconic signs can more effectively prime lexical access due to greater alignment between features of the picture and the semantic and phonological features of the sign. We speculate that naming latencies are facilitated for motorically-iconic signs due to later processes (e.g., faster phonological encoding via cascading activation from semantic features). Overall, the results indicate that type of iconicity plays role in sign production when elicited by picture-naming tasks.

Domain specificity of error monitoring: An ERP study in young and older adults.

Metacognition refers to the ability to monitor and control one's cognitive processes, which plays an important role in decision-making throughout the lifespan. It is still debated whether metacognitive abilities decline with age. Neuroimaging evidence suggests that metacognition is served by domain-specific mechanisms. These domains may differentially decline with increasing age. The current investigates whether the error-related negativity (ERN) and the error positivity (Pe) which reflect error detection and error awareness, respectively, differ across perceptual and memory domains in young and older adults. In total, 38 young adults and 37 older adults completed a classic Flanker Task (perceptual) and an adapted memory-based version. No difference in ERN amplitude was found between young and older adults and across domains. Perceptual ERN peaked earlier than Memory ERN. Memory ΔERN was larger than Perceptual ΔERN. Pe was smaller in older adults and ΔPe was larger for perceptual than memory flanker. Memory Pe peaked earlier in young as compared to older adults. Multivariate analyses of whole scalp data supported cross-domain differences. During the task, ERN decreased in young but not in older adults. Memory Pe decreased in young adults but increased in older adults while no significant change in perceptual Pe was found. The study's findings suggest that neural correlates of error monitoring differ across cognitive domains. Moreover, it was shown that error awareness declines in old age but its within-task dynamics vary across cognitive domains. Possible mechanisms underlying metacognition impairments in aging are discussed.

Unpleasant words can affect the detection of morphosyntactic errors: An ERP study on individual differences.

In recent years, several ERP studies have investigated whether the early computation of agreement is permeable to the emotional content of words. Some studies have reported interactive effects of grammaticality and emotionality in the left anterior negativity (LAN) component, while others have failed to replicate these results. Furthermore, novel findings suggest that grammatical processing can elicit different neural patterns across individuals. In this study, we aim to investigate whether the interaction between grammaticality and emotionality is restricted to participants with a specific neural profile. Sixty-one female native speakers of Spanish performed an agreement judgment task in noun phrases composed of a determiner, a noun, and an unpleasant or neutral adjective that could agree or disagree in gender with the preceding noun. Our results support the existence of two different brain profiles: negative and positive dominance (individuals showing either larger LAN or larger P600 amplitudes in ungrammatical stimuli than in grammatical ones, respectively). Interestingly, the neural pattern of these two groups diverged at different points along the time course. Thus, the negative dominance group showed grammaticality effects as early as 200 ms, along with parallel and autonomous processing of grammaticality and emotionality at the LAN/N400 time window. Instead, for the positive dominance group an early interaction was found at around 200 ms, evidencing a grammaticality effect that emerged only for unpleasant words. Our findings confirm the role of individual differences in the interplay between grammar and emotion at the neural level and call for the inclusion of this perspective in studies on syntactic processing.

“Beyond the literal meaning” processing implied emotion in second language discourse: an ERP study

ABSTRACT Emotion is processed incrementally during sentence comprehension in a first language (L1) due to unification operations. Since processing multiple types of information is cognitively more demanding in a second language (L2), we investigated implied emotion processing in L1 and L2 using event-related brain potentials. We presented native Spanish speakers with sentences whose context rendered neutral words either negative-congruent, neutral-congruent or neutral-incongruent in Spanish (L1) and English (L2). Results showed differences in early emotion processing across languages: a larger N100 for neutral than negative sentences in L1 and a more positive P300 for negative than neutral sentences in L2. Effects in the N400 and LPP time windows were not language dependent. An N400 semantic incongruity effect was present in both languages. A gradual LPP effect was larger for negative than incongruent sentences in both languages, with neutral sentences in between. Results indicate early time-window differences in implied emotion processing across languages.

Social anxiety modulating early processing for social threat words: an ERP study

ABSTRACT Even though some recent research revealed individuals with HSA typically display enhanced processing in the early stages of emotional information processing due to hypervigilance and vulnerability to negative stimuli, it is still unclear whether social anxiety affects the time course underlying processing bias for emotional stimuli. Therefore, the present study aimed to explore the early stage of processing social threat stimuli in high social anxiety (HSA) individuals by recording RTs and EEG data in the emotional Stroop task. Behavioral data showed that the HSA group responded to the threat words faster than neutral words (i.e. negative bias), but no emotional effects in the low social anxiety (LSA) group. Although the P1 component did not show any early effects, ERP data exhibited an enhanced N170 for HSA than for LSA groups. Threat words elicited larger N170 than neutral words in the LSA group only; this emotion effect was not evident in the HSA group. These findings indicated that social anxiety modulates early processing for social threat words. This study revealed the neural mechanisms underlying early emotional processing in individuals with social anxiety, providing insights for the evaluation and intervention of social anxiety.

The time course of Cantonese and Hong Kong Sign Language phonological activation: An ERP study of deaf bimodal bilingual readers of Chinese

This study investigated Cantonese and Hong Kong Sign Language (HKSL) phonological activation patterns in Hong Kong deaf readers using the ERP technique. Two experiments employing the error disruption paradigm were conducted while recording participants’ EEGs. Experiment 1 focused on orthographic and speech-based phonological processing, while Experiment 2 examined sign-phonological processing. ERP analyses focused on the P200 (180–220 ms) and N400 (300–500 ms) components.The results of Experiment 1 showed that hearing readers exhibited both orthographic and phonological effects in the P200 and N400 windows, consistent with previous studies on Chinese reading. In deaf readers, significant speech-based phonological effects were observed in the P200 window, and orthographic effects spanned both the P200 and N400 windows. Comparative analysis between the two groups revealed distinct spatial distributions for orthographic and speech-based phonological ERP effects, which may indicate the engagement of different neural networks during early processing stages.Experiment 2 found evidence of sign-phonological activation in both the P200 and N400 windows among deaf readers, which may reflect the involvement of sign-phonological representations in early lexical access and later semantic integration. Furthermore, exploratory analysis revealed that higher reading fluency in deaf readers correlated with stronger orthographic effects in the P200 window and diminished effects in the N400 window, indicating that efficient orthographic processing during early lexical access is a distinguishing feature of proficient deaf readers.

Garden of forking paths in ERP research - Effects of varying pre-processing and analysis steps in an N400 experiment.

This study tackles the Garden of Forking Paths, as a challenge for replicability and reproducibility of ERP studies. Here, we applied a multiverse analysis to a sample ERP N400 dataset, donated by an independent research team. We analyzed this dataset using 14 pipelines selected to showcase the full range of methodological variability found in the N400 literature using systematic review approach. The selected pipelines were compared in depth by looking into statistical test outcomes, descriptive statistics, effect size, data quality, and statistical power. In this way we provide a worked example of how analytic flexibility can impact results in research fields with high dimensionality such as ERP, when analyzed using standard null-hypothesis significance testing. Out of the methodological decisions that were varied, high-pass filter cut-off, artifact removal method, baseline duration, reference, measurement latency and locations, and amplitude measure (peak vs. mean) were all shown to affect at least some of the study outcome measures. Low-pass filtering was the only step which did not notably influence any of these measures. This study shows that even some of the seemingly minor procedural deviations can influence the conclusions of an ERP study. We demonstrate the power of multiverse analysis in both identifying the most reliable effects in a given study, and for providing insights into consequences of methodological decisions.