Using a computer may lead to pain in wrists, neck, and back. In addition, adopting various body postures like sitting cross-legged, semi-fowler's position, and putting the laptop on the leg may lead to the development of persistent and irreversible discomfort. The purpose of this research is to design and build an adjustable ergonomic laptop desk based on the anthropometric characteristics of students in the age range of 20 to 30 years and to evaluate its efficiency using RULA and NERPA methods. This cross-sectional study conducted on 108 students, in which an adjustable and portable ergonomic desk designed and built based on 10 anthropometric dimensions of students and the length and width of 10 different laptop models. Two assessment methods, RULA and NERPA, were used. Wilcoxon statistic test and SPSS version 26 software used for data analysis. The dimensions of the desk were calculated in three positions, and the desk was made with the ability to adjust height, width and tilt, each with two degrees of freedom. The statistical analysis comparing score of RULA and NERPA in two situations without using a desk and using an ergonomic laptop desk had a significant difference (P-value < 0.001). Comparison of RULA and NERPA scores showed that NERPA evaluated the low ergonomic risk level better than RULA method. Due to the ability to adjust the designed desk, the changes in RULA and NERPA score in all three modes, it indicates the effectiveness of the table in improving the body posture of users when using a laptop.