Background & Aims: Erector spinae plane block (ESPB) is newer block being tried in various surgical procedures. Our study was designed to evaluate the effectiveness of ultrasonography (USG) guided ESPB to provide postoperative analgesia following percutaneous nephrolithotomy (PCNL). Patients scheduled for PCNL surgery were enroled in prospective, randomised, Methods: double-blinded group study. Patients were randomised to group A and group B. Patients in Group A (n = 33) received subcutaneous inltration of 20 mL of 0.25% bupivacaine at the incision site and Group B (n = 33) received USG guided ESPB with 20 mL of 0.25% bupivacaine postoperatively. Numeric rating scale (NRS) scores were assessed at intervals of 30 min, 60 min, then hourly for six h, followed by four hourly up to 24 h. The primary objective of the study was to compare postoperative pain relief using the NRS score between the two groups. Secondary outcomes were to compare analgesic requirement and to assess the incidence of complications. Student's t-test was used to check the normality of each variable in terms of mean deviation and standard deviation. A comparison was analysed using Mann–Whitney test. For categorical data, Chi-square test was used. NRS scores were lower in Group B Results: than Group A. There was signicant prolongation in time for rst analgesia in Group B (12 h) compared to Group A (30 min). There was a signicant reduction in total tramadol consumption at 24 h postoperatively in the ESPB group. Ultrasound-guided ESPB is an Conclusion: efcacious analgesic technique with an opioid-sparing effect following PCNL.