You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation I1 Apr 20121150 A PROSPECTIVE LONGITUDINAL SURVEY OF ERECTILE DYSFUNCTION RATE IN PATIENTS WITH LOCALIZED PROSTATE CANCER TREATED WITH PERMANENT PROSTATE BRACHYTHERAPY Masashi Matsushima, Eiji Kikuchi, Takahiro Maeda, Akitomo Sugawara, Toshiyuki Ando, Hirohiko Nagata, Akira Miyajima, Ken Nakagawa, Naoyuki Shigematsu, and Mototsugu Oya Masashi MatsushimaMasashi Matsushima Tokyo, Japan More articles by this author , Eiji KikuchiEiji Kikuchi Tokyo, Japan More articles by this author , Takahiro MaedaTakahiro Maeda Tokyo, Japan More articles by this author , Akitomo SugawaraAkitomo Sugawara Tokyo, Japan More articles by this author , Toshiyuki AndoToshiyuki Ando Tokyo, Japan More articles by this author , Hirohiko NagataHirohiko Nagata Tokyo, Japan More articles by this author , Akira MiyajimaAkira Miyajima Tokyo, Japan More articles by this author , Ken NakagawaKen Nakagawa Tokyo, Japan More articles by this author , Naoyuki ShigematsuNaoyuki Shigematsu Tokyo, Japan More articles by this author , and Mototsugu OyaMototsugu Oya Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1260AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Few studies have evaluated changes in erectile function (EF) over time before and after prostate brachytherapy (PB) using the International Index of Erectile Function (IIEF)-15. IIEF-15 is a sensitive and validated tool for the evaluation of male sexual dysfunction. In this prospective study, the natural history of EF after PB without supplemental therapies (external beam radiotherapy, phosphodiesterase-5 inhibitors, and androgen deprivation therapy) was studied using IIEF-15 questionnaires. METHODS We identified 119 patients who were followed-up for at least 12 months after PB between 2004 and 2010. Sexual status and EF status were assessed before PB (baseline), and 3, 6, 12, 18, 24, and 36 months postoperatively using IIEF-15 questionnaires. Differences between pretreatment baseline scores and follow-up measurements at 3, 6, 12, 18, 24, and 36 months after PB were tested. RESULTS The mean total IIEF score, EF domain, orgasmic function domain, sexual desire domain, and intercourse satisfaction domain scores at 3 months after PB were significantly lower than those of baseline scores (p<0.05) and remained lower until 36 months after PB (Table 1). The mean overall satisfaction domain score after PB deteriorated temporarily at 3 to 18 months after PB (p<0.05), but then recovered to baseline level 24 months postoperatively. Of the 48 patients who had EF at baseline, EF was maintained for 12 months after PB in 16 men (33.3%). There were no significant differences in clinical features except for the age between patients who could maintain EF and those who had worsening EF 12 months after PB. Multivariate analysis demonstrated that age ¡Ý70 was the only predictive factor for exacerbating EF after PB (Odds ratio; 6.655, p=0.041). PSA, clinical stage, total IIEF score before PB, past history, and Gleason score had no effect on the ultimate preservation of potency. Table 1. IIEF and IIEF domain score before and after brachytherapy No of Pts Before PB 3mo after PB 6mo after PB 12mo after PB 18mo after PB 24mo after PB 36mo after PB 119 106 107 119 61 29 29 Domain EF 10.3±10.3 7.3⁎±9.0 8.0⁎±9.1 7.5⁎±8.8 7.8⁎±8.6 8.5⁎±8.3 6.3⁎±7.6 OF 3.7±4.0 2.1⁎±3.2 2.5⁎±3.4 2.5⁎±3.4 2.7⁎±3.4 3.1⁎±3.3 2.0⁎±3.1 SD 4.0±2.6 3.3⁎±2.5 3.6⁎±2.5 3.5⁎±2.5 3.6⁎±2.3 4.0⁎±2.2 3.8⁎±2.3 IS 3.2±4.3 1.9⁎±3.6 2.2⁎±3.7 2.1⁎±3.7 2.1⁎±3.8 2.3⁎±3.6 1.6⁎±3.3 OS 5.9±1.5 5.4⁎±1.5 5.6⁎±1.5 5.4⁎±1.7 5.4⁎±1.7 5.5±1.5 5.8±1.5 IIEF 27.1±20.7 20.1⁎±17.8 21.8⁎±18.1 20.9⁎±18.0 21.6⁎±17.3 23.3⁎±16.7 19.4⁎±15.9 IIEF, Internal Index of Erectile Function; Pts, patients; EF, erectile function; OF, orgasmic function; SD, sexual desire; IS, intercourse satisfaction; OS, overall satisfaction; PB, prostate brachytherapy; ⁎ P 0.05 compared to values before brachytherapy CONCLUSIONS The findings indicate that there had been a global decrease in all domains of the IIEF score 12 months after PB and that patient age may influence PB-related potency preservation. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e466 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Masashi Matsushima Tokyo, Japan More articles by this author Eiji Kikuchi Tokyo, Japan More articles by this author Takahiro Maeda Tokyo, Japan More articles by this author Akitomo Sugawara Tokyo, Japan More articles by this author Toshiyuki Ando Tokyo, Japan More articles by this author Hirohiko Nagata Tokyo, Japan More articles by this author Akira Miyajima Tokyo, Japan More articles by this author Ken Nakagawa Tokyo, Japan More articles by this author Naoyuki Shigematsu Tokyo, Japan More articles by this author Mototsugu Oya Tokyo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...