ABSTRACT Aim of the Work Aim of the work is to evaluate the effect of intracavernosal injection of platelet-rich plasma (PRP) for the treatment of arteriogenic erectile dysfunction (ED). Methods This study was conducted up on 25 men complaining of mild-to-moderate ED, who were in a stable relationship for more than 1 year. Results After 6 months of intracavernosal PRP injection, there was a statistically significant improvement of the International Index of Erectile Function-Erectile Function domain score, which then declines after 1 year of the treatment. No adverse effects were observed during the study. Conclusions PRP intracavernosal injections may be a promising option for the management of arteriogenic ED. But further studies are needed to confirm these findings.