Erectile Dysfunction In Middle-aged Men Research Articles

Relationship between erectile dysfunction and moderate to severe prostatitis-like symptoms in middle-aged men: a propensity score-matched analysis.

We assessed the relationship between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED) using propensity score matching. Data from 8727 middle-aged men who had undergone health checkups were analyzed. The National Institutes of Health Chronic Prostatitis Symptoms Index (NIH-CPSI), the International Index of Erectile Function-5 (IIEF), the Premature Ejaculation Diagnostic Tool (PEDT), testosterone measurement, basic blood chemistry, and metabolic syndrome (MetS) assessment were performed in this study. Of the 8727 men considered, 7181 formed the cohort for propensity score matching, including 597 men with moderate to severe prostatitis-like symptoms (case) and 6584 men with no prostatitis-like symptoms (control); ultimately, however, members of the case and control groups were matched at a 1:1 ratio by propensity score. After matching, the variables of age, testosterone, PEDT and MetS were evenly distributed between the groups. After matching, the mean IIEF score of the case group was significantly lower than that of the control group (17.2 ± 5.5 vs. 14.7 ± 5.3; P < 0.001). Additionally, the severity of ED was significantly greater in the case group (no, mild, mild to moderate, moderate, and severe, respectively: 27.5%, 30.2%, 24.6%, 13.1%, and 4.7% in the control group; 10.7%, 27.0%, 33.0%, 18.9%, and 10.4% in the case group; P < 0.001). Finally, the rate of moderate to severe ED was significantly higher in the case group than in the control group (17.8% vs. 29.3%; P < 0.001). Moderate to severe prostatitis-like symptoms were significantly and independently correlated with ED in middle-aged men.

AB045. Post-micturition dribbling is associated with erectile dysfunction in middle-aged men with lower urinary tract symptoms

BackgroundPost-micturition dribbling (PMD) is one of the most bothersome lower urinary tract symptoms (LUTS) in men. Researches on the PMD are very limited because no proper tool to evaluate PMD. This study was to assess the correlation between PMD and erectile dysfunction (ED) in middle-aged men with LUTS.Methods658 middle-aged men with LUTS were enrolled. Patients filled in international prostate symptom score (IPSS) and Hayllm PMD questionnaire (HPMDQ) that was made by authors. Prostate size, prostate specific antigen, uroflowmetry including Qmax & post voided residual urine, IPSS, and international index for erectile function-5 (IIEF-5) were also assessed.ResultsMen were classified as ED (388 patients) and non-ED (270 patients) groups. HPMDQ was inversely well correlated with IIEF-5 (r=-0.384, p<0.001). Prevalence of ED was related to PMD severity (p=0.001). Predictive accuracy of HPMDQ for ED was not superior to that of other LUTS (each p>0.05). However, incorporation of HPMDQ into IPSS increased predictive accuracy of LUTS for ED (60.3% ⋄73.1%).ConclusionsIn middle-aged men with LUTS, PMD was inversely well correlated with erectile function, and its severity was related with prevalence of ED.AppendixHallym Post-Micturition Dribbling Questionnaire (HPMDQ). “In the past month, how often have you experienced the involuntary loss of urine immediately after you finished passing urine?” 0: none, 1: one in 3 times, 2: two in 3 times, 3: always.

Hormonal determinants of erectile dysfunction and lower urinary tract symptoms in middle-aged and elderly men with prediabetes

Objectives: Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) are common in diabetic men. The aim of this study was to investigate hormonal determinants, the prevalence and severity of ED and LUTS in middle-aged and elderly men with prediabetes (PD).Methods: We investigated 176 men with PD and 184 healthy peers. PD was defined according American Diabetes Association. ED according IIEF scale and LUTS according IPSS scale were assessed. Total testosterone (TT), calculated free testosterone (cFT), dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor 1 (IGF-1) were measured.Results: The prevalence of ED in patients with PD was higher than in control group (30 versus 24%) as well as the prevalence and severity of ED and LUTS in elderly (60–80 years) and middle-aged (40–59 years) men with PD was higher than in healthy peers. In middle-aged pre-diabetic men, the more severe LUTS symptoms were associated with low TT and DHEAS, while in elderly men with low cFT and DHEAS. The higher prevalence of ED in middle-aged men with PD was associated with cFT and DHEAS, while in elderly pre-diabetic men with TT and IGF-1.Conclusions: The prevalence and severity of LUTS and ED symptoms were higher in pre-diabetic men than in healthy peers. Hormonal determinants of these symptoms are different in middle-aged and elderly patients with PD.

Physical Activity and Erectile Dysfunction in Middle‐Aged Men

The prevalence of erectile dysfunction is high in men of all ages and increases greatly in the elderly. In particular, severity and prevalence both increase with aging. Because erectile dysfunction is a symptom, physicians should diagnose underlying pathologies that might lead to it instead of focusing only on finding a viable treatment. Physical inactivity negatively impacts on erectile function; experimental and clinical exercise interventions have been shown to improve sexual responses and overall cardiovascular health. Several studies have confirmed that combining 2 interventions (Mediterranean diet and physical activity) provides additional benefit to erectile function, likely via reduced metabolic disturbances (eg, inflammatory markers, insulin resistance), decreased visceral adipose tissue, and improvement in vascular function (eg, increased endothelial function). This brief review shows the main clinical evidence of benefits induced by physical activity on erectile and endothelial dysfunction. The literature shows that erectile dysfunction in middle-aged men is often an early event in endothelial damage, and physical activity is able to improve both erectile and endothelial dysfunction. There are conflicting data regarding the effects of exercise on androgen status. In clinical practice it would be recommended to add regular physical activity to balanced diet and drugs to achieve better therapeutic results.

FUNCTIONAL STATUS OF ERECTILE COMPONENT IN PATIENTS WITH CHRONIC PROSTATITIS

The paper presents research data on the functional assessment erectile dysfunction in middleaged men with chronic prostatitis. Identified singns indicate significant effects of chronic prostatitis on erectile disorder

The association of arterial stiffness with erectile dysfunction in middle-aged men with metabolic syndrome

The association of arterial stiffness with erectile dysfunction in middle-aged men with metabolic syndrome

Preliminary report of association of chronic diseases and erectile dysfunction in middle-aged men in Japan

ObjectivesTo investigate the effect of chronic diseases on erectile dysfunction (ED) in Japanese middle-aged men using the International Index of Erectile Function, 5-item version (IIEF-5). MethodsThe subjects consisted of 640 healthy men and 396 men with chronic disease who responded to the IIEF-5 questionnaire (mean age 43.6 ± 8.3 years, range 30 to 59). The incidence and severity of ED were calculated in three age groups (30 to 39, 40 to 49, and 50 to 59 years). ResultsThe incidence of hypertension, cardiac disease, diabetes mellitus, and chronic renal failure was associated with the incidence and severity of ED, as was age. In stepwise multivariate logistic regression analysis, cardiac disease was the strongest independent risk factor (odds ratio [OR] 6.5), followed by diabetes mellitus (OR 5.9), chronic renal failure (OR 3.9), hypertension (OR 2.0), and age (OR 1.8). ConclusionsThe results of this study demonstrated that the risk of ED increases with the presence of cardiac disease, diabetes mellitus, chronic renal failure, and hypertension in middle-aged men in Japan.