Vibrating screens have wide applications in various industries, ranging from agriculture to coal mining. In recent years, improvement in production have put forward higher requirements on the efficiency of vibrating screens. However, these large screens are prone to fatigue damage, particularly crack formation, over time. The emergence of substantial dynamic inertial forces can be attributed to the considerable body mass of a large vibrating screen. This study analyzed the structural strength of the HZXZ200x300 large vibrating screen, employing finite element simulation to identify the maximum equivalent stress and primary stress distribution. The main frame model of the vibrating screen box was constructed by integrating the equivalent static load and submodule methods. The model transitioned from dynamic response to static optimization under equivalent static and dynamic loads, significantly reducing calculation scale and enhancing optimization efficiency. Equivalent static sub-models were employed for topology optimization, determining the optimal structure for material performance distribution. This process yielded an optimal conceptual model for reconstructing the actual model. The structural strength was further improved by comparing three-dimensional and dynamic local stress relationships post-topological optimization, followed by reinforcing the vibrating screen structure and introducing reinforced bars for increased stability. The study showed that lightweight topology optimization significantly decreased the stress levels and improved the fatigue durability of beams. Local strengthening, accomplished via topology optimization, effectively reduced the maximum equivalent stress to 76.487 MPa, a decrease of 46.8%. The vibrating screen mass also decreased by 225 kg, a reduction of 14.9%. In summary, this study employed structural analysis, topology optimization, and local reinforcement to mitigate stress levels, enhance the fatigue life of a vibrating screen, and reduce its weight. This study offers an effective solution to the dynamic optimization challenges of complex structures.