Equivalent Loss Research Articles

Metabolomic Fingerprints of Medical Therapy Versus Bariatric Surgery in Patients With Obesity and Type 2 Diabetes: The STAMPEDE Trial.

Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are effective procedures to treat and manage type 2 diabetes (T2D). However, the underlying metabolic adaptations that mediate improvements in glucose homeostasis remain largely elusive. The purpose of this study was to identify metabolic signatures associated with biochemical resolution of T2D after medical therapy (MT) or bariatric surgery. Plasma samples from 90 patients (age 49.9 ± 7.6 years; 57.7% female) randomly assigned to MT (n = 30), RYGB (n = 30), or SG (n = 30) were retrospectively subjected to untargeted metabolomic analysis using ultra performance liquid chromatography with tandem mass spectrometry at baseline and 24 months of treatment. Phenotypic importance was determined by supervised machine learning. Associations between change in glucose homeostasis and circulating metabolites were assessed using a linear mixed effects model. The circulating metabolome was dramatically remodeled after SG and RYGB, with largely overlapping signatures after MT. Compared with MT, SG and RYGB profoundly enhanced the concentration of metabolites associated with lipid and amino acid signaling, while limiting xenobiotic metabolites, a function of decreased medication use. Random forest analysis revealed 2-hydroxydecanoate as having selective importance to RYGB and as the most distinguishing feature between MT, SG, and RYGB. To this end, change in 2-hydroxydecanoate correlated with reductions in fasting glucose after RYGB but not SG or MT. We identified a novel metabolomic fingerprint characterizing the longer-term adaptations to MT, RYGB, and SG. Notably, the metabolomic profiles of RYGB and SG procedures were distinct, indicating equivalent weight loss may be achieved by divergent effects on metabolism.

A pandemic-related affect gap in risky decisions for self and others

ABSTRACT The early stages of the COVID-19 pandemic exposed large portions of the global populations to increased daily stressors. Research on risky choice in medical contexts suggests that affect-rich choice options promote less-advantageous decision strategies compared with affect-poor options, causing an “affect gap” in decision making. The current experiments (total N = 437, age range: 21–82) sought to test whether negative pandemic-related affect would lower expected-value (EV) maximisation within individuals. In Experiment 1, participants indicated how much they would be willing to pay to avoid specific pandemic experiences (e.g. “not being able to gather in groups”), and then chose among pairs of risky prospects that involved pandemic experiences or subjectively-equivalent monetary losses. EV maximising was lower for pandemic experiences than for equivalent monetary losses. Experiment 2 replicated this finding, and further demonstrated a moderating role of decision perspective. EV maximising was greater in decisions made for another person than in decisions made for oneself. These findings highlight potential strategies for boosting decision making under affect-rich real-world conditions.

An Ice Loss Evaluation of Lake-Terminating Glaciers Based on Lake Bathymetry—A Case Study of the Jiongpu Glacier

Lake-terminating glaciers are among the most severely retreating glacier types in high mountain areas. However, the characteristic of being covered by glacial lakes after retreat makes it hard to estimate their actual ice loss in recent years, as does the contribution of different parts in ice loss, which leads to significant obstacles not only in evaluating solid water resources but understanding inter-relationships between glacial ice and glacial lakes. This study presents a detailed investigation of Jiongpu Co, one of the biggest glacial lakes in the Tibetan Plateau, including its bathymetry and area evolution. The ice loss in the last two decades was analyzed using a multisource DEM dataset. The main results showed that from 1976 to 2021, Jiongpu Co had expanded from 1.19 ± 0.09 km2 to 5.34 ± 0.07 km2. The volume of Jiongpu Co showed a surprising increment from 0.09 ± 0.004 Gt to 0.66 ± 0.03 Gt from 1976 to 2021, leading to a subaqueous equivalent ice loss of 0.32 ± 0.01 Gt water from 2000 to 2020 and resulting in an underestimated ice loss of 0.06 Gt, 19% compared with previous evaluations. The total ice loss of the Jiongpu glacier was 1.52 ± 0.37 Gt from 2000 to 2020, and more than 1/3 ice loss was related to lake expansion (0.32 ± 0.01 Gt underwater, 0.19 ± 0.02 Gt above water). This study makes a further contribution to the understanding of ice loss in the complicated system of lake-terminating glaciers.

МОДЕЛЮВАННЯ АСИНХРОННИХ МАШИН У СКЛАДІ ЕЛЕКТРОМЕХАНІЧНИХ СИСТЕМ З УРАХУВАННЯМ ВТРАТ У СТАЛІ СТАТОРА

A comparative study has been conducted on methods for accounting for the influence of losses in the stator iron of squirrel-cage induction motors on the operating parameters. A comparison was made between reference data and calculation results of the nominal mode parameters of an asynchronous motor without considering losses in the stator iron and with their consideration using equivalent resistances connected in parallel to the motor, as well as equivalent circuits of losses in the stator. The effect of the ratio of active and inductive components of the load of equivalent stator loss circuits on the results of mathematical modeling has been investigated. The study was carried out based on a universal mathematical model of an asynchronous motor of electromechanical systems with an arbitrary stator winding scheme. An algorithm for determining and adjusting the parameters of the stator loss circuits during the integration of the differential equations of electrical and mechanical balance of the asynchronous motor to a steady-state value has been developed, based on the values of losses in the stator iron (depending on the induction and frequency) and the effective value of the current of the equivalent circuit. To ensure solution stability, the use of an iteration coefficient and discretization of resistance adjustment has been justified. The application of stator iron loss circuits in the mathematical model of an asynchronous machine in generator mode has been justified, when the use of parallel connected equivalent resistances contradicts the machine's energy diagram. References 10, figure 1, table 1.

Study on hysteresis performance of corroded CHS T-joints under in-plane bending load

This research aims to examine the hysteresis behavior of corroded circular hollow section (CHS) T-joints when subjected to cyclic bending loading. Quasi-static tests including the coupling of brace axial load and in-plane cyclic moment were conducted on corroded CHS T-joint specimens to analyze the effects of corrosion damage on the hysteresis curve, failure mechanism, carrying capacity, and energy dissipation of the joints. Experimental results indicated the corrosion damage located at the different regions of joints had varying effects on the hysteresis behaviors of CHS T-joints. 1) The brace corrosion degree was more severe than the chord corrosion degree under the same exposure condition, however, the chord corrosion had a more significant influence on reducing the stiffness and ultimate carrying capacity of CHS T-joints. The ultimate capacity of CHS T-joints was found to decline by more than 20 % when the equivalent thickness loss of the chord was about 9.2 %. 2) Compared with chord corrosion, the brace corrosion would relieve the concave deformation and local plastic deformation of the chord so that more plastic cyclic damage concentrated around the intersection line. As a result, the through cracks prematurely occurred from the crown points on both sides, and the energy dissipation of CHS T-joints declined by more than 25 % when the equivalent thickness loss of the brace was about 13 %. The presence of axial loading on the brace not only affects the symmetry of hysteresis curves in CHS T-joints with non-uniform corrosion, but also exacerbates the concave deformation of the chord in chord corroded joints during the failure stage, thereby affecting the shape of hysteresis loops and fracture behavior of CHS T-joints when subjected to in-plane cyclic bending load.

A New Perspective on the Scattering Mechanism of S-Band Weather Radar Clear-Air Echoes Based on Communication Models

Clear-air echo studies are usually based on isotropic turbulence theory. But the theory has been considered incomplete by modern turbulence theory. The intermittence of turbulence can reveal obvious shortcomings in the existing studies of clear-air echoes. The mechanism of clear-air echo scattering needs to be supplemented. This paper introduces the troposcatter theory, normally used in over-the-horizon communication, to fill the gap left by Bragg scattering. By treating radar as a self-transmitted and self-received device, the equivalent transmission loss of weather radar is established and compared with the recommendations of the Radiocommunication Sector of the International Telecommunication Union (ITU-R). The results show that the S-band radar transmission loss aligns with ITU-R recommendations. There is also a linear regression relationship between the radar transmission loss and height, which conforms to the troposcatter theory. This means that the theory of troposcatter scattering is a supplement to the theory of Bragg scattering. Tropospheric scattering can be thought of as general Bragg scattering. Meanwhile, based on ITU-R recommendations, this study also provides a new way for the recognition of biological echoes.

Coupling ideality of standing-wave supermode microresonators

Standing-wave supermode microresonators that are created through the strong coupling between counter-propagating modes have emerged as versatile platforms for sensing and nonlinear optics. For example, these microresonators have shown potential in nanoparticle sizing and counting, as well as enhancing the single-photon optomechanical coupling rate of stimulated Brillouin scattering. However, it has been observed that the relation between the mode linewidth and on-resonance transmission of the split supermodes differs obviously from that of the non-split modes. This behavior is typically quantified by the coupling ideality (I), which remains inadequately explored for the standing-wave supermodes. In this study, we theoretically and experimentally investigate the coupling ideality of standing-wave supermodes in a commonly employed configuration involving a SiO2 microresonator side-coupled to a tapered fiber. Our findings demonstrate that, even with a single-mode tapered fiber, the coupling ideality of the standing-wave supermodes is limited to 0.5, due to the strong backscattering-induced energy loss into the counter-propagating direction, resulting in an additional equivalent parasitic loss. While achieving a coupling ideality of 0.5 presents challenges for reaching over-coupled regimes, it offers a convenient approach for adjusting the total linewidth of the modes while maintaining critically-coupled conditions.

Chronic treatment with glucagon-like peptide-1 and glucagon receptor co-agonist causes weight loss-independent improvements in hepatic steatosis in mice with diet-induced obesity

ObjectivesCo-agonists at the glucagon-like peptide-1 and glucagon receptors (GLP1R/GCGR) show promise as treatments for metabolic dysfunction-associated steatotic liver disease (MASLD). Although most co-agonists to date have been heavily GLP1R-biased, glucagon directly acts on the liver to reduce fat content. The aims of this study were to investigate a GCGR-biased co-agonist as treatment for hepatic steatosis in mice. MethodsMice with diet-induced obesity (DIO) were treated with Dicretin, a GLP1/GCGR co-agonist with high potency at the GCGR, Semaglutide (GLP1R monoagonist) or food restriction over 24 days, such that their weight loss was matched. Hepatic steatosis, glucose tolerance, hepatic transcriptomics, metabolomics and lipidomics at the end of the study were compared with Vehicle-treated mice. ResultsDicretin lead to superior reduction of hepatic lipid content when compared to Semaglutide or equivalent weight loss by calorie restriction. Markers of glucose tolerance and insulin resistance improved in all treatment groups. Hepatic transcriptomic and metabolomic profiling demonstrated many changes that were unique to Dicretin-treated mice. These include some known targets of glucagon signaling and others with as yet unclear physiological significance. ConclusionsOur study supports the development of GCGR-biased GLP1/GCGR co-agonists for treatment of MASLD and related conditions.

Robust multitask learning in high dimensions under memory constraint

AbstractWe investigate multitask learning in the context of multivariate linear regression with high dimensional covariates and heavy‐tailed noise, while under the constraint of limited memory. To tackle the computational complexity arising from the non‐smoothness of the quantile loss, we reformulate it as an equivalent least squares loss, which yields robust solutions even in the presence of heavy‐tailed noise. We incorporate a group lasso penalty into the quantile loss to produce sparse solutions, and an accelerated proximal sub‐gradient descent algorithm to speed up the computation while ensuring explicit forms for penalized solutions at each iteration. The proposed algorithm is general and can be applied to similar optimization problems. Moreover, we introduce a communication‐efficient distributed algorithm that guarantees optimal convergence rates after finite communication rounds in cases where computing resources such as memory are insufficient. We also study the theoretical properties of the resultant estimate and relax the widely used model selection consistency assumption on the initial estimate. We demonstrate the effectiveness of our proposal through extensive numerical studies.

Effects of rapid or slow body weight reduction on glucose tolerance during equivalent weight loss in rats fed high-fat diet

Effects of rapid or slow body weight reduction on glucose tolerance during equivalent weight loss in rats fed high-fat diet

Macroprudential policy with earnings-based borrowing constraints

A large literature has studied optimal regulatory policy in macroeconomic models with asset-based collateral constraints. A common conclusion is that agents ‘over-borrow’ and optimal policy reduces debt positions through taxes. The reason is that agents do not internalize the effects of their choices on asset prices. However, recent empirical evidence shows that firms primarily borrow against their earnings rather than their assets. This paper studies optimal macroprudential policy with earnings-based borrowing constraints, both in closed and open economies. We reach the opposite conclusion to the previous literature. Agents ‘over-save’ (and ‘under-borrow’) relative to the social optimum, as they do not internalize changes in wages, which in turn affect firms’ earnings. A numerical model exercise demonstrates that incorrectly rolling out a tax policy derived under the assumption of asset-based constraints in an economy where firms actually borrow based on earnings leads to a consumption equivalent welfare loss of up to 2.55%. Optimal macroprudential policy thus critically depends on the specific form of financial constraints.

A rapid prediction model for the radiation efficiency of baffled constrained layer damping plate

It’s well-known that constrained layer damping (CLD) can effectively reduce the vibration and radiation noise from the (plate-like or shell-like) thin-walled structures under various of dynamic excitations. As one of the key properties deciding the CLD’s performance, the CLD’s acoustic radiation characteristics has always been a focus of researchers. In this study, an analytical model based on equivalent principle is proposed to predict the acoustic radiation efficiency of the CLD plate. In this model, a laminated CLD plate is equivalent to a single-layer plate and the equivalent stiffness and loss factor are obtained using the strain energy method. The vibration velocity of the plate is calculated using mode-superposition method and the sound pressure on the plate surface is calculated using Rayleigh integral formula. Variable mesh sizes and frequency steps are employed to improve the calculation efficiency. The difference between the base and CLD plates in sound radiation characteristics is investigated using this model. The results indicate that CLD involving a damping layer with a low Young’s modulus can mitigate more vibration at low frequencies. A higher Young’s modulus of the damping layer results in a higher radiation efficiency of the CLD plate between the fundamental and critical frequencies. By increasing the loss factor, the spatially averaged mean square velocity would decrease, more modes would contribute to the response, and the CLD plate can consequently achieve a higher radiation efficiency below the critical frequency. Moreover, the simplified formulae for the average radiation efficiency of the CLD plate is developed to achieve the rapid calculation. Its accuracy is then validated by comparing the results to the more comprehensive model.

Including environmental and social sustainability in the planning process of healthcare services: A case study of cancer screening programs in an inner area in Italy

Healthcare systems plan their activities to achieve efficiency and effectiveness, without addressing environmental and social sustainability. This paper describes a new approach adopted in Italy to plan and deliver health prevention services in an inner area of the Tuscany region (in Italy) to guarantee proximity of care and environmental and social sustainability. The project examines the design and delivery of cancer screening programmes using a mobile screening unit to maximise social benefits while minimising environmental waste. A cost analysis was developed to estimate the difference in CO2 equivalent emissions, travel costs, and productivity losses, comparing the current screening programmes against the introduction of a comprehensive full-service mobile screening unit. The results indicate that the new service model reduces direct non-medical costs incurred by the population and improves environmental sustainability. This alternative can reduce, annually, over 95,000 euros in terms of travel costs and productivity losses, as well as 35 tons of CO2-equivalent travel emissions for a population of 59,000 inhabitants in a mountainous area with around 6000 people involved in the screening programme. The study supports the need to adopt a new planning methodology that considers environmental, social, and financial sustainability jointly in the provision of public health services in rural areas.

On-line minimum loss control strategy of IPMSM in torque-controlled application

This study proposes an on-line minimum loss (ML) control strategy that considers the iron and copper losses of an interior permanent magnet synchronous motor in torque-controlled applications. The proposed ML control strategy utilizes a constrained optimization problem to satisfy torque reference tracking and loss minimization. An equivalent iron loss resistance circuit is adopted for the loss minimization. To solve the optimization problem, the Lagrange multiplier method is applied through a numerical analysis algorithm. The resulting solution provides the optimal current reference for every sampling instant. The Lagrange multiplier method needs parameters such as magnetic flux linkages, dynamic inductances, and iron loss resistance. Fundamental magnetic flux linkages are estimated using a flux observer, and the dynamic inductances are estimated with high-frequency voltage signal injection. The proposed iron loss resistance estimator estimates the equivalent iron resistance without any preliminary experiments. DC input power is measured using a current sensor for the accurate on-line estimation of iron loss resistance. To analyze the effectiveness of ML control compared with conventional maximum torque per ampere control, finite element analysis is used. The feasibility of the proposed ML control strategy is verified through simulation and experiments.

Accelerated degradation test method and performance prediction with service mileage of the yaw damper in railway vehicles

The performance of the yaw damper for rail vehicles degrades significantly degradation after long-term operation, which directly affects the dynamic behaviour of the vehicle operation. To quickly achieve the performance degradation of the yaw damper and predict the operating mileage under actual service conditions, the operating displacement spectrum of the yaw damper under actual operating conditions is analysed and decomposed using the short-time Fourier transform. Based on the equivalent principle of energy loss during vibration attenuation, an accelerated test method is proposed for the performance degradation of yaw dampers. By conducting the accelerated degradation test of the yaw damper on the test bench, the continuous degradation relationship between the performance parameters of the damper and the loading times is obtained. By combining the operating displacement spectrum and the accelerated degradation test data, the performance degradation trajectory model of the yaw damper is established, taking into account the equivalent energy loss between the service mileage and the loading times. The mapping relationship among loading times, service mileage and performance degradation is constructed. Finally, parameter performance tests are conducted on yaw dampers under different service mileage to verify the accuracy of the performance degradation trajectory model. The results show that the proposed acceleration test method and degradation trajectory model can quickly realise the performance degradation of the damper and accurately predict the performance parameters for different service mileage under actual operating conditions.

Efficacy and Safety of Dapagliflozin in Patients With Acute Heart Failure

BackgroundThe primary goals during acute heart failure (AHF) hospitalization are decongestion and guideline-directed medical therapy (GDMT) optimization. Unlike diuretics or other GDMT, early dapagliflozin initiation could achieve both AHF goals. ObjectivesThe authors aimed to assess the diuretic efficacy and safety of early dapagliflozin initiation in AHF. MethodsIn a multicenter, open-label study, 240 patients were randomized within 24 hours of hospital presentation for hypervolemic AHF to dapagliflozin 10 mg once daily or structured usual care with protocolized diuretic titration until day 5 or hospital discharge. The primary outcome, diuretic efficiency expressed as cumulative weight change per cumulative loop diuretic dose, was compared across treatment assignment using a proportional odds model adjusted for baseline weight. Secondary and safety outcomes were adjudicated by a blinded committee. ResultsFor diuretic efficiency, there was no difference between dapagliflozin and usual care (OR: 0.65; 95% CI: 0.41-1.02; P = 0.06). Dapagliflozin was associated with reduced loop diuretic doses (560 mg [Q1-Q3: 260-1,150 mg] vs 800 mg [Q1-Q3: 380-1,715 mg]; P = 0.006) and fewer intravenous diuretic up-titrations (P ≤ 0.05) to achieve equivalent weight loss as usual care. Early dapagliflozin initiation did not increase diabetic, renal, or cardiovascular safety events. Dapagliflozin was associated with improved median 24-hour natriuresis (P = 0.03) and urine output (P = 0.005), expediting hospital discharge over the study period. ConclusionsEarly dapagliflozin during AHF hospitalization is safe and fulfills a component of GDMT optimization. Dapagliflozin was not associated with a statistically significant reduction in weight-based diuretic efficiency but was associated with evidence for enhanced diuresis among patients with AHF. (Efficacy and Safety of Dapagliflozin in Acute Heart Failure [DICTATE-AHF]; NCT04298229)

Metasurface-based polarization-insensitive absorber with dual-band tunable absorption intensity

In this paper, a polarization-insensitive absorber with dual-band tunable absorption intensity is proposed. Two absorption bands are generated by introducing external branches into a ring structure. Since the resistance of the loaded PIN diode changes with bias current, the reflectivity of two absorption bands can be dynamically adjusted from almost 0 dB to less than −10 dB at normal incidence. Inductors are loaded on both sides of the metal structure, which guarantees not only that the units are connected during DC feeding, but also the symmetry of the metal structure in RF band to ensure polarization insensitivity. The mechanisms of dual absorption bands and tunable absorption intensity are revealed through the detailed analysis of resonant modes, equivalent circuit model, surface current, and loss density distribution. A sample prototype has also been fabricated, and the measured results are well consistent with the simulated ones. The proposed absorber has the unique advantage of dynamic tuning of dual-band absorption intensity, making it a versatile choice in modern communication, radar, and stealth systems.

Development of Louvered Noise Barrier with Changeable Sound Insulation from Waste Tire Rubber and Investigation of Acoustic Properties

In line with circular economy principles, the recycling and reuse of tire rubber waste are considered highly advanced and environmentally friendly waste disposal methods. Through the repurposing of tire rubber waste, the goal is to minimize environmental impact while creating a louvered noise barrier with sound attenuation capabilities. The acoustic properties of the structure made of used tire rubber granulate are investigated in this research. Firstly, nine rubber granulate plates of different fractions, thickness, and density were produced. Two plates with the best results were selected after an impedance tube analysis of their sound absorption (α) and sound transmission loss (DTL). These plates were used as a filler in the structure of the louvers. The efficiency of the structure and its dependence on the tilting angle of the louvers and the number of plates were investigated in a semi-anechoic sound-absorbing chamber. The maximum sound level reduction observed was 17.3 dB (in the 8000 Hz frequency band), and the maximum equivalent sound level loss (LAeq) was 7.3 dBA.

Heatwaves are detrimental to fertility in the viviparous tsetse fly.

Heatwaves are increasing in frequency and intensity due to climate change, pushing animals beyond physiological limits. While most studies focus on survival limits, sublethal effects on fertility tend to occur below lethal thresholds, and consequently can be as important for population viability. Typically, male fertility is more heat-sensitive than female fertility, yet direct comparisons are limited. Here, we measured the effect of experimental heatwaves on tsetse flies, Glossina pallidipes, disease vectors and unusual live-bearing insects of sub-Saharan Africa. We exposed males or females to a 3-day heatwave peaking at 36, 38 or 40°C for 2 h, and a 25°C control, monitoring mortality and reproduction over six weeks. For a heatwave peaking at 40°C, mortality was 100%, while a 38°C peak resulted in only 8% acute mortality. Females exposed to the 38°C heatwave experienced a one-week delay in producing offspring, whereas no such delay occurred in males. Over six weeks, heatwaves resulted in equivalent fertility loss in both sexes. Combined with mortality, this lead to a 10% population decline over six weeks compared to the control. Furthermore, parental heatwave exposure gave rise to a female-biased offspring sex ratio. Ultimately, thermal limits of both survival and fertility should be considered when assessing climate change vulnerability.

Hormonal intrauterine devices and heat exchange during exercise.

Synthetic progestins in oral contraceptives are thought to blunt heat dissipation by reducing skin blood flow and sweating. However, whether progestin-releasing intrauterine devices (IUDs) modulate heat loss during exercise-heat stress is unknown. We used direct calorimetry to measure whole-body total (dry + evaporative) heat loss in young, physically active women (mean (SD); aged 24(4)years, 39.3(5.3) ml/kg/min) with (IUD; n=19) and without (Control; n=17) IUDs in the follicular and luteal phases of the menstrual cycle during light- and moderate-intensity exercise at fixed rates of heat production (∼175 and ∼275W/m2 ) in 30°C, ∼21% relative humidity. Between-group and -phase differences were evaluated using traditional hypothesis testing and statistical equivalence testing within pre-determined bounds (±11W/m2 ; difference required to elicit a ±0.3°C difference in core temperature over 1h) in each exercise bout. Whole-body total heat loss was statistically equivalent between groups within ±11Wm-2 (IUD-Control [90% CIs]; Light: -2 [-8, 5] W/m2 , P=0.007; Moderate: 0 [-6, 6] W/m2 , P=0.002), as were dry and evaporative heat loss (P ≤ 0.023), except for evaporative heat loss during moderate-intensity exercise (equivalence: P=0.063, difference: P=0.647). Whole-body total and evaporative heat loss were not different between phases (P≥0.267), but dry heat loss was 3 [95% CIs: 1, 5] W/m2 greater in the luteal phase (P≤0.022). Despite this, all whole-body heat loss outcomes were equivalent between phases (P≤0.003). These findings expand our understanding of the factors that modulate heat exchange in women and provide valuable mechanistic insight of the role of endogenous and exogenous female sex hormones in thermoregulation. KEY POINTS: Progestin released by hormonal intrauterine devices (IUDs) may negatively impact heat dissipation during exercise by blunting skin blood flow and sweating. However, the influence of IUDs on thermoregulation has not previously been assessed. We used direct calorimetry to show that IUD users and non-users display statistically equivalent whole-body dry and evaporative heat loss, body heat storage and oesophageal temperature during moderate- and high-intensity exercise in a warm, dry environment, indicating that IUDs do not appear to compromise exercise thermoregulation. However, within IUD users and non-users, dry heat loss was increased and body heat storage and oesophageal temperature were reduced in the luteal compared to the follicular phase of the menstrual cycle, though these effects were small and unlikely to be practically meaningful. Together, these findings expand our understanding of the factors that modulate heat exchange in women and have important practical implications for the design of future studies of exercise thermoregulation.