Equivalent Amount Research Articles

Highly enhanced reactivity of HCl on the Ag/Au(111) alloy surface via rotational quantum state excitation.

Rotational excitations of reactants are often considered to have little impact on chemical reactivity compared to the excitations of vibrational modes and translational motion. Here, we reveal a significant influence of the rotational excitation of HCl on its dissociation on an Ag/Au(111) alloy surface. This finding is based on six-dimensional time-dependent wave packet calculations performed on an accurately fitted machine learning potential energy surface. Rotational energy is found to be 90 times more effective in driving the reaction than an equivalent amount of translational energy. The reactivity of HCl on Ag/Au(111) is diminished due to a charge transfer effect, which induces a strongly non-monotonic dependence of the minimum energy path on molecular orientation, resulting in the HCl molecule deviating from the minimum barrier. We identify and detail two underlying mechanisms by which rotationally excited HCl can overcome the charge transfer effect between Au and Ag atoms, leading to enhanced reactivity and an intriguing rotational-alignment phenomenon. This finding underscores the profound impact that rotational excitations can exert on molecular reactivity, emphasizing a delicate interplay between various forms of molecular energy and their respective contributions to the reaction mechanism.

Electrodeposition of Extremely Cu-Rich CuPd Bimetallic Nanoparticles from an Amide-Type Hydrophobic Protic Ionic Liquid

Abstract Cupric oxide (CuO) and palladium(II) acetate (Pd(Ac)2) were dissolved into the amide-type hydrophobic protic ionic liquid (IL), protonated-betaine bis((trifluoromethyl)sulfonyl)amide ([Hbet][TFSA]), to produce the Cu(II) and Pd(II) species for the electrodeposition of metallic Cu, Pd, and CuPd nanoparticles (NPs). Unlike the electrodeposition conducted in common aqueous electrolytes containing the equivalent amounts of Cu and Pd ions, Cu-rich rather than Pd-rich CuPd co-deposits were obtained from the IL [Hbet][TFSA]; which might result from the retardation of Pd deposition on preferentially electrodeposited Cu surface or the formation of a new metal species when both metal ions co-existed in the IL, leading to an uncommon large overpotential needed to reduce the species into Pd metal. The surface morphologies of CuPd NPs significantly relied on their elemental compositions that could be controlled by the concentration of Pd(II) and/or the applied electrodeposition potential. CuPd NPs with different Pd contents showed very different responses in the reaction current of nitrate reduction. Nevertheless, the CuPd NPs regardless of the Pd contents showed advantages over the Cu nanoparticles in the electrochemical reduction of nitrate, which might be due to the synergistic effects between the Cu and Pd atoms.

Capacity, Volume Flexibility, and Costs

This paper studies strategic firms' capacity choices in the presence of demand uncertainty and imperfect downside and upside volume flexibility. It provides conditions under which firms' capacity is greater or less than their expected output. It shows under certain conditions, a first-order stochastically dominant demand distribution induces higher capacity, while a mean-preserving spread of a demand distribution induces lower capacity. By endogenizing volume flexibility, it shows that firms' downside flexibility tends to be lower than their upside flexibility. This implies a firm's short-run average cost tends to be asymmetrically U-shaped, namely, the average cost increases more when output falls below capacity (the efficient scale) than when output rises above capacity by an equivalent amount.

The Iron Spin Transitions in Hydrous Fe3+‐Bearing Bridgmanite and Its Geophysical Properties in the Lower Mantle

AbstractHydrous Fe3+‐bearing bridgmanite (Bdg) is potentially a critical water host in the lowermost mantle. The spin transition behaviors of such materials are pivotal for understanding geophysical heterogeneity in the deep Earth but are poorly understood. Here, we investigated the spin transition and related geophysical properties of Fe3+ with associated H defects [Fe3+‐H] at high P‐T conditions using first‐principles simulations. Our calculations predict that the presence of hydrogen reduces the onset pressure of the spin transition of Fe3+ in Bdg, leading to higher fractions of low spin Fe3+. Along standard geotherms, spin transition is predicted to remain incomplete even at the core‐mantle boundary (CMB), and lateral temperature variations would significantly affect the proportions of high and low spin Fe and related properties like elasticity. The thermoelastic property of hydrous Fe3+‐bearing bridgmanite exhibit stronger softening anomalies at the lower mantle conditions compared to dry system, which potentially enhancing the seismic detectability of the hydrous Bdg in the deep earth. Density profile of hydrous Fe3+‐bearing bridgmanite indicates that the [Fe3+‐H] defect modestly increases the system's density, but much less than that caused by incorporating an equivalent amount of iron alone. This is crucial for understanding regions like Large Low Shear Velocity Provinces (LLSVPs), which exhibits large velocity drops but only minor density changes. The co‐adsorption of Fe and H allows for the introduction of Fe to induce velocity drops without the concomitant sharp increase in density, as pure iron would, thus enabling Fe‐H enrichment as a potential source of LLSVPs.

Complexation of magnesium ions in sodium dodecyl benzenesulfonate-Flopaam AN125SH mixtures using sodium citrate

Presence of divalent metal ions, especially alkaline earth cations in brine water is an important factor during different processes applying anionic surfactants and negatively charged polymers, because these cations bind to the anionic head group of surfactants and may cause the precipitation of these materials. They also interact with the polymer chains, decreasing the polymer’s viscosity, reducing the net charge of the polymer chains, which also may lead to precipitation. The present study focuses on describing the interactions between magnesium ions with anionic sodium dodecyl benzenesulfonate (SDBS)–Flopaam AN125SH mixtures and the complexation of the magnesium with sodium citrate. Description of these interactions are important to evaluate the applicability of sodium citrate to decrease the undesired effects of alkaline earth cations in polymer-surfactant mixtures. The mixtures contained the high molecular weight anionic polymer in constant 1.0 g/L concentration and the surfactant in 5.0 g/L concentration. The magnesium ion concentration was systematically increased in the samples (0.03–1.5 g/L) and sodium citrate was added to the magnesium ion containing samples in 2.0 and 3.0 M equivalent amount compared to the magnesium ion concentration. The samples were characterized by using turbidimetry and rheology measurements (measuring consistency index, yield stress, flow number and zero shear viscosity), as the change of viscosity is an important parameter during application of polymers in different processes. The formed precipitates were characterized using infrared spectroscopy. The results showed that sodium citrate successfully inhibited the magnesium ions caused precipitation up to 1.2 g/L metal ion concentration (1200 ppm), but caused a considerable decrease in the viscosity of the samples (the consistency index of the mixtures decreased from 47.5 mPa s to 7.53 mPa s) and that magnesium ions do not induce precipitation of the polymer. However, this amount of decrease in viscosity did not change the flow properties of the polymer, all the investigated samples were measured to possess pseudoplastic flow behavior. The viscosity decreasing effects of the sodium citrate were also measured and approximately 13.0 mPa s decrease was measured in zero shear viscosity.

Effect of Oat Hay as a Substitute for Alfalfa Hay on the Gut Microbiome and Metabolites of Yak Calves.

To evaluate the impact of different roughages on the intestinal microbiota of yak calves, we fed them oat hay in substitution of alfalfa hay, in addition to milk replacer and starter powder. Twenty-one 45-day-old male yak calves were selected and randomly assigned to three groups: the milk replacer + starter + alfalfa hay group (AH), the milk replacer + starter + oat hay group (OH), and the milk replacer + starter + mixed hay group (AO), in which the alfalfa hay and oat hay were administered in a 1:1 ratio. All calves in the three groups were fed the same milk replacer and an equivalent amount of dry matter. The formal experiment commenced after a 21-day pre-test period and lasted for 120 days. Following the experiment, the contents of the jejunum and colon were collected to investigate the intestinal microbiota and metabolites using 16S rRNA sequencing and LC-MS metabolomics. The result showed that the AO group had greater final body weights overall than the AH group and OH group (p < 0.05). The AH group and OH group had considerably greater feed-to-gain ratios than the AO group (p < 0.05). At the phylum level, the OH group exhibited an increased relative abundance of Bacteroidota and Spirochaetota in the jejunum (p < 0.05). The relative abundance of Actinobacteriota in the colon was increased in the AO group (p < 0.05). At the genus level, the AO group exhibited a decreased abundance of Clostridium sensu_stricto_1 (p < 0.05), and the OH group showed an increased abundance UCG-005 and Alistipes in the jejunum. There were many differential metabolites in the OH group and AO group compared to the AH group, and the different metabolites of the OH group were associated with the metabolic pathways of the nervous system, sensory system, amino acid metabolism, and lipid metabolism in the jejunum and with lipid metabolism, amino acid metabolism, and the nervous system in the colon. In the AO group, these metabolites were associated with the digestive system and the translation and metabolism of cofactors in the jejunum and with the metabolism of cofactors and vitamins in the colon. In summary, it is feasible to replace alfalfa hay with oat hay based on milk replacer and starter. The combination of the two forages enhanced nutrient absorption, improved immune function, maintained the internal homeostasis of yak calves, and was more beneficial to their growth and development.

Novel Approach to Fat Reduction: A Phase I Study Evaluating Safety and Tolerability of STP705 in Abdominoplasty

Background: RNAi therapeutics are a rapidly developing technology with broad medical applications predicated on reducing the expression of genes with key links to disease pathogenesis. The TGF-β1/Smad3 and COX-2 signaling pathways are strongly implicated in obesity and type 2 diabetes. Reducing the expression of TGF-β1 and COX-2 may have benefits in fat reduction procedures. The aim of this study was to assess the safety and tolerability of STP705 (a TGF-β1/COX-2 siRNA complex in a polypeptide nanoparticle vehicle) injections in persons undergoing abdominoplasty. A secondary aim was to make initial histologic observations on the efficacy of STP705 injections in inducing adipocyte apoptosis for the purpose of focal fat reduction. Methods: The study treatment consisted of 3 rounds of treatment with 7 subcutaneous abdominal injections of STP705 or placebo. Eight female subjects aged 18-65 years received 120 μg, 240 μg, or 360 μg STP705 in 0.5 or 1.0 ml doses (per injection) or an equivalent amount of placebo injected randomly across seven 1 cm2 areas. Treatments were administered 28 days apart with follow-ups occurring at 2 and 7 days’ post-procedure. Tissue samples from each of the 7 injection sites were harvested from total abdominoplasty excisional specimens obtained 28 days after the final injection. Safety assessments were conducted, including physical examination, clinical laboratory tests, electrocardiograms, evaluation of local skin reactions (LSRs), and collection of adverse events (AEs). Lipolytic and inflammatory effects of STP705 were assessed by blinded histologic analysis of harvested tissue samples. Results: There were no clinically significant changes in clinical labs, vital signs, or ECGs. The incidence of LSRs was low throughout the study. There were 3 moderate AEs deemed likely to be related to STP705 injection; none required intervention, and all resolved without dose modification. Histology revealed marginally dose-dependent tissue response with adipocyte destruction and fat remodeling. Conclusion: In general, STP705 was well tolerated at all concentrations and volumes studied. STP705 demonstrated excellent safety, and initial histologic analysis is suggestive of its efficacy in adipocyte destruction. The lack of cutaneous side effects with STP705 injection is an advantage over current treatments for similar indications.

Tailored dielectric properties of polypropylene nanocomposites through laboratory synthesized titania

Nanofillers have drawn utmost attention for their ability to enhance the dielectric properties of polymers in the field of high voltage insulation. Usually, a small fraction of nanofillers are added to polymers, and promising dielectric property changes are resulted. Titania (TiO2) nanofiller has been widely incorporated in different polymers for dielectric properties improvements. However, the effects of rutile TiO2 and anatase TiO2 on the structure and dielectric properties of polypropylene (PP) nanocomposites have yet to be systematically compared especially from the perspective of nanodielectrics. In this study, the effects of rutile TiO2 and anatase TiO2 nanofillers on the structure and dielectric properties of PP were investigated. The rutile TiO2 and anatase TiO2 nanofillers were laboratory synthesized through a sol–gel method using two calcination temperatures, i.e., 700 °C and 450 °C, respectively. The results revealed that the rutile TiO2 and anatase TiO2 had distinct effects on the structure and dielectric properties of PP nanocomposites. Significantly, the dielectric performance of PP nanocomposites containing anatase TiO2 outperformed that containing equivalent amount of rutile TiO2. Possible mechanisms governing these changes are discussed.

CARBON CAPTURE, USAGE AND STORAGE

Carbon Capture, Usage and Storage – in short CCUS, is not a new term in the current industrial environment. It is being discussed widely at all industrial forums, across all countries, big or small, to control pollution to ensure a healthy and happy life for all. There have been attempts and studies over last 50 years to capture carbon dioxide from the environment to avoid pollution and control global warming scenario. Many technologies have been in use for carbon capture, across the globe, some in large scale and others confined to local areas. It is expensive but very much essential – it is a goal set by WHO/UNO/European Commission – to clean the environment off CO2 gases, use it for alternative purposes or store it for future action. According to International Energy Agency (IEA), we must capture around 100 billion tons of CO2 by 2060 to meet International Global Warming and Energy goals. It is a huge goal and is a very expensive goal to achieve. All big countries who impact the environment in a huge way through their industries shall come forward for a collaboration to prepare a robust plan, pump-in money, monitor and control the processes, to achieve the goal. There is an estimate that US emitted around 5,1 mln t of CO2 in 2019 whereas Global estimate emitted around 33 mln t. These are very huge numbers and hence Global monitoring is very essential to control emission and safe storage and disposal. It is important to understand that Carbon Capture (CC), Carbon Capture and Use (CCU) and Carbon Capture and Storage (CCS) are three different terms. CC, CCU and CCS are combinedly termed as CCUS. CC is to capture carbon from various sources – fuel gas, fossil fuels, petroleum products, flares from refineries and power plants etc. Usage of the captured carbon in the form of carbon dioxide (CO2) is CCU and this is an important long-term vision by any government to ensure it is being used meaningful to avoid negative impact on climate. CCS is storage of the captured carbon quickly so that it does not impact the environment as a greenhouse gas and at the same time, it can be used later. Another term which is frequently used is Net Zero CO2. It is defined as follows: Any CO2 released into the atmosphere from a human activity shall be balanced by an equivalent amount being removed, either by nature-based solutions (including afforestation, reforestation or other changes in land use) or technological solutions that stores CO2 captured directly or indirectly, permanently. Net Zero CO2 is very important, unless this is achieved, CCUS goal cannot be achieved to control climate change. This write-up provides an insight into the following topics:  What is CCUS?  Why is it important?  Steps to CCUS;  CAPEX and OPEX involved.

Oat polar lipids and sunflower lecithin similarly improve cardiometabolic risk markers and appetite controlling hormone responses after breakfast and a subsequent lunch. A randomized crossover study in healthy adults.

The alarming global increase in lifestyle-related disorders such as obesity and type 2 diabetes mellitus (T2DM) has increased during the last several decades. Poor dietary choices significantly contribute to this increase and prevention measures are urgently needed. Dietary intake of bioactive compounds found in foods are linked to a decrease likelihood of these disorders. For this purpose, a randomized crossover meal study was performed to compare the postprandial metabolic effects of lecithin and oat polar lipids in healthy subjects. Eighteen young healthy subjects ingested test meals enriched with lecithin, oat polar lipids (PLs) or rapeseed oil. There were four test meals (i) 15 g oat polar lipids: OPL, (ii) 18 g sunflower lecithin (of which 15 g were polar lipids): LPL, (iii) 18 g rapeseed oil: RSO, and (iv) reference white wheat bread: WWB. Lipid-enriched test meals contained equivalent amounts of total fat (18 g), and all breakfast meals contained 50 g available carbohydrates. The meals were served as breakfast followed by a standardised lunch (white wheat bread and meat balls) after 3.5 h. Test variables were measured at fasting and repeatedly during 5.5 h after ingestion of the breakfast. Our study demonstrated that both LPL and OPL had beneficial effects on postprandial glucose and insulin responses, and appetite regulating gut hormones, as compared to RSO and WWB. Significant increase in GLP-1, GIP, and PYY concentrations were seen after consuming breakfast meals with LPL and OPL, and ghrelin concentration was reduced compared to meals with RSO and WWB (p < 0.05). Furthermore, triglycerides (TG) concentration was significantly reduced after OPL compared to RSO (p < 0.05). Our data show that there were no significant variations in glycaemic and insulin responses, TG, and gut hormone concentrations between LPL and OPL during breakfast (0-210 min) or over the whole study period (0-330 min). Our study revealed that the consumption of both lecithin and oat PLs included in breakfast meal may similarly enhance postprandial glucose tolerance, reduce TG, and enhance the secretion of incretins and appetite regulating hormones in healthy young adults. ClinicalTrials.gov, identifier NCT05139355.

Whey protein-based bigels for co-encapsulation of curcumin and gallic acid: Characterization, stability and release kinetics

Bigels are a class of soft matter systems with great promise for the food industry as food analogs or as enhanced ingredient substitutes. This work aimed to improve the curcumin (CUR) and gallic-acid (GA) stability, antioxidant capabilities, and controlled release by co-encapsulating them within bigels. This delivery system included a bigel made by whey protein isolate (WPI) aggregates-based oleogel and WPI-based hydrogel in equivalent amounts (50:50). The following techniques were used to evaluate how different bigels affected the chemical stability of CUR and GA: X-ray diffraction (XRD), thermogravimetric analysis (TGA), 1H-nuclear magnetic resonance (1H-NMR), and Fourier infrared (FTIR) spectroscopy. As a result of the protein's ligand-binding abilities, some components may co-adsorb to oil droplet surfaces. Next, it was determined how well the bigels performed as a carrier and looked at their physicochemical stability, digestion, and performance. Examining the release rate of CUR and GA during digestion showed that bigel had a slower release rate (6–15%) than oleogel (16%) and hydrogel (34%), and CUR had a lower release (50%) due to its higher molecular weight and greater entanglement than GA (70%). The stability of bigel (against heat and light) was also higher than oleogel and hydrogel due to having a higher solid component that requires more stress to be applied to the system. CUR and GA had more antioxidant activity in bigel (96.24%) than oleogel (77.71%) and hydrogel (77.34%); which can be attributed to the formation of ultra-fine colloidal dispersions by bigel, allowing more CUR and GA to interact with free radicals by creating more contact surface. The multi-functional bigels showed great potential for delivering antioxidants to the intestine while enhancing their stability. Hydrophobic interactions and hydrogen bonding between WPI and CUR-GA were validated by FTIR analysis, that kept bigels stable. Overall, our findings demonstrated that WPI-based bigels with intriguing UV light, color, and thermal stability could be developed. This would increase the use of bigels in innovative food products with high nutritional value.

Clausius' theorem and the second law in the process of isoenergetic thermalization.

Isoenergetic thermalization amongst n bodies is a well-known irreversible process, bringing the bodies to a common temperature T_{F} and leading to a rise in the total entropy of the bodies. We express this change in entropy using the Clausius formula over a reversible path connecting T_{F} with T_{f}, which corresponds to the entropy-preserving temperature of the initial nonequilibrium state. Under the assumption of positive heat capacities of the bodies, the second law inequality simply follows from the fact that T_{F}>T_{f}. We extend this approach to the continuum case of an unequally heated rod, illustrating with the special case of the rod with constant heat capacity and a linear temperature profile. An interpolating profile between the discrete and the continuum models is studied whereby T_{f}, given by the geometric mean temperature over n elements, is shown to approach the identric mean of the lowest and the highest temperatures as n becomes large. We also discuss the case of negative heat capacity in a two-body set up where isoenergetic thermalization may be forbidden by the second law. However, the alternate scheme in which first work is performed reversibly on the system and then an equivalent amount of energy is extracted in the form of heat, brings the system to an energy-preserving common temperature.

The benefits and burdens of wind power systems in reaching China's renewable energy goals: Implications from resource and environment assessment

Recognizing the economy's growing reliance on global energy landscape transformation on wind power deployment, as well as the general reality that renewable facilities require lower operational but higher up-front inputs than fossil-based power systems, this paper focuses on the life-cycle burdens of wind power systems and their substitution benefits compared with coal-fired power systems. The estimation considers the consumption of nonrenewable sources of energy, emissions of greenhouse gases, and other environmental resource factors that have received significantly less research attention, such as industrial land use, water use, PM2.5, SO2, NOX, and Hg emissions. The scope of this study differs from earlier ones in that it includes a comprehensive description of all the equipment, materials, and services used, as opposed to earlier studies that either omit crucial supporting infrastructure or just focus on the plant's physical structure as its primary materials. Results based on a typical plant in China show that the state-of-the-art onshore wind power systems can provide significant reductions in nonrenewable energy use (9.2 MJ/kWh) and GHG emissions (782.8 GtCO2/kWh). To produce an equivalent amount of electricity, wind power systems require more than three times industrial land use and almost one-third of industrial water use of that for traditional coal-fired power systems. The avoided SO2, Hg, PM2.5, and NOX emissions per unit of electricity generation account for 60.6%–89.3% of the total air pollution emissions induced by supercritical coal-fired power systems. By integrating 3797 operating plant-specific data and fixed-point wind energy information, this study scales up results of the single plant to a country level. The macro picture implies different opportunities born by wind power systems in easing multiple resource and environmental pressures, highlighting the significance of designing hierarchical strategies to improve penetration levels of wind power. By 2050, cumulative climate benefits obtained from onshore wind power technology are predicted to reach 74.2 Gt CO2, achieving around 17.2%–45.5% of the national carbon-neutral goal.

Enhancing Mandarin Tone and Vowel Recognition in Cochlear Implant Simulation through Combining Task Practice

Purpose: Mandarin tone recognition with cochlear implant simulation can be enhanced via targeted auditory training. However, such training generally does not transfer to different tasks, even when they share the same stimuli. As such, this study investigated whether combined Mandarin tone and vowel recognition training leads to greater improvements in Mandarin tone, vowel, and sentence recognition compared to tone- or vowel- only training.Methods: Twenty-nine native Mandarin-speaking young adults with normal hearing were randomly assigned to one of three training regimens: Tone-Only, Vowel-Only, Tone-Vowel. Mandarin tone, vowel, and sentence recognition were tested before and after training.Results: Tone-Only training improved Mandarin tone recognition but not vowel recognition, while Vowel-Only training improved Mandarin vowel recognition but not tone recognition. The combined Tone-Vowel training improved both tone and vowel recognition. ToneVowel training also led to improvements in Mandarin sentence recognition, although these gains were not significantly greater than those observed in Tone-Only or Vowel-Only groups.Conclusion: These findings suggest that within an equivalent amount of training, combined tone and vowel recognition training enhances both tone and vowel recognition, while tone- or vowel-only training improves the performance in the targeted task alone. Combined tone and vowel recognition may be necessary to achieve improvements in Mandarin tone, vowel, and sentence recognition.

Multi-Source Monitoring and Numerical Simulation Deformation on Highway Steep Slopes Under Rainfall Effects

Rainfall is one of the most important factors affecting slope stability. This study employed multi-source monitoring devices to observe the slope displacements in real time under rainfall infiltration and performed numerical simulations to investigate the effects of different rainfall conditions and anti-slip pile configurations on slope stability. Specifically, multi-source monitoring operations were conducted on the high and steep slopes along the Yunmao Expressway. Real-time data on slope deformation, rainfall, and displacement at the tops of anti-slip piles were collected and analyzed, and numerical simulations were conducted using Geo Studio finite-element software. The findings indicated that abrupt deformation of slopes occurs once a threshold rainfall amount is surpassed and sustained over a specific duration. Slope displacement decreased with increasing slope depth above the potential slip fracture surface, with a more rapid reduction in deformation rates observed in slopes reinforced with anti-slip piles. For equivalent rainfall amounts, short-duration, intense rainfalls led to a rapid decrease in the slope safety factor, which also recovered rapidly once the rainfall ceased, in contrast to long-duration, mild rainfalls. The presence and location of anti-slip piles significantly influenced slope stability; therefore, project implementation should carefully consider factors such as cost and duration for optimal decision making.

Production of Anthocyanin-Enriched Juices by Electrodialysis with Filtration Membrane Process: The Influence of Duration on Juice Composition, Process Efficiency, and Membrane Fouling.

The Electrodialysis with Filtration Membrane (EDFM) system has shown promise in juice enrichment, but further optimization is needed. This study evaluated the effect of processing duration (3 and 6 h) on juice composition, process efficiency, and membrane fouling. Results demonstrated a significant impact of processing time on juice composition, especially anthocyanin and mineral content. Two anthocyanin-depleted juices (-18.94% and -30.70%) and two anthocyanin-enriched juices (26.21% and 44.21%) were produced. Similar energy (1512.13 Wh/g of anthocyanins) was required to migrate equivalent amounts of anthocyanins over both time periods, with no impediment due to fouling observed, although the system's resistance increased (2.5-fold after 3 h, 3.2-fold after 6 h). Membrane fouling was characterized through conductivity, thickness, ATR-FTIR, SEM-EDX, and foulant identification. Minimal anthocyanin accumulation occurred on cation-exchange membranes (CEM), while anthocyanins and PACs concentrated within the filtering layer of filtration membranes (FM). However, fouling did not increase with longer processing. Structural alterations were noted in anion-exchange membranes (AEMs), suggesting instability under high electric fields. Overall, EDFM effectively enriched cranberry juice with anthocyanins, but further research is necessary to address AEM degradation under limiting current density conditions.

ASSESSMENT OF THE ECONOMIC EFFICIENCY OF USING ORGANO-MINERAL FERTILIZERS AND GROWTH STIMULANTS IN POTATO FIELDS CULTIVATED IN THE CONDITIONS OF FOOTHILL ZONE

The article presents the results concerning calculations of the economic efficiency of the potato harvest, obtained under the influence of the equivalent amounts of organo-mineral fertilizers and different ways of applying growth-stimulating bio-liquid in the post-forest medium capacity brown soils of the foothill zone of the Republic of Artsakh, in the early-ripening impala variety potato sowings, cultivated under arid conditions. According to economic calculations of the average data of three-year experimental research studies, it was revealed that the highest yield and economic efficiency in potato plantings was provided by the version of fractional application of bio-liquid and organomix norms (bio-liquid 14 l/ha-1 norm to soak the planting material 3 days before sowing, 5 t/ha-1of organomix in sowing and 3 t/ha-1ha norm to be applied with nutrition), which ensured a high-quality potato harvest of 36.47 t/ha-1 and an additional benefit of 2 million 152.6 thousand AMD. At the same time, providing a high compensation for the additional costs incurred, with the results of impact and post-impact per 1 dram spent, a net profit of 3.95 AMD. The above-mentioned version of fertilization was proposed for wide implementation in the region and in agro-zones with similar soil and climatic conditions of the Republic of Armenia.

Seasonal Variability of Human Enteric Viruses Discovered in Food Production Mussels (Mytilus galloprovincialis) Farmed in the Central Adriatic Sea (Italy).

Among the different naked and quasi-enveloped viruses, the hepatitis A virus (HAV), hepatitis E virus (HEV), and norovirus genogroups I and II (NoV GI and NoV GII) are considered the main microbiological noxae involved in foodborne outbreaks. Mussels can harbor pathogens in their tissues. In addition to epidemiological attention, marine water temperature changes are considered a crucial variable influencing viral loads. This study aimed to biomolecularly screen 1775 farmed mussels (Mytilus galloprovincialis) for viral ribonucleic acid (RNA) sequence detection (belonging to the HAV, HEV, and NoV GI and GII genogroups) in three different sampling periods (spring, summer, and winter), with the mussels collected from three farms located in the Central Adriatic Sea (Italy). The results showed that 10.42% of the screened animals harbored at least one type of pathogen RNA, more specifically, 5.35% HEV, 4.51% NoV GI, and 0.56% HAV. The highest genetic equivalent (GE) amounts were majorly observed in the winter season (NoV GI 1.0 × 103 GE/g and HEV 1.0 × 102 GE/g), resulting in statistical differences when compared to summer and spring (p-value: <0.001). The original data obtained serve to bring scientific attention to the possible influence of environmental and climatic aspects on viral loads, highlighting the crucial role played by biomolecular assays as preventive medicine tools.

Exploring Border Conditions for Spontaneous Emergence of Chirality in Allylboration of 1,2,3-Triazolic Aldehydes.

A case of spontaneous chirality generation was observed during a synthetic project studying the allylboration of 1,2,3-triazolic aldehydes. Here, we present computational studies supported by experimental findings targeting the elucidation of border conditions required for the observation of spontaneous chirality generation in the reaction of 1-Ar-1H-1,2,3-triazole-4-carbaldehydes 1a,b with triallylborane. Three possible sources of symmetry breaking were found computationally. Thus, dimerization of the initial reaction products, alcoholates 4a,b, gives dimers 5a,b (homochiral) and 6a,b (heterochiral). The latter were computed to be more stable thermodynamically, which can lead to amplification of the initial stochastic imbalance of the enantiomers of 4a,b via the reservoir mechanism. Furthermore, enantiomeric excess can be increased during the transfer of the second allylic group in the reaction of optically active boronates 4a,b with 1a,b, which was computed to be enantioselective due to the strong activating and stereoregulating properties of the 1,2,3-triazole group. In addition, reactions of borinic esters 8a,b, products of the previous reaction with triallylborane, recovered in each case two molecules of 4a,b of the same handedness, which can lead to additional chirality amplification. Experimentally, reactions of optically active alcohols (+)-R-2a,b with triallylborane provided chiral alcoholates 4a,b, which were reacted with equivalent amounts of corresponding aldehydes 1a,b. Unexpectedly, in two series of 10 experiments each, preferential formation of both enantiomers of the newly formed product was observed: seven times S and three times R in the case of 1a and six times S and four times R in the case of 1b.

ADAM8 promotes alcoholic liver fibrosis through the MAPK signaling pathway

The effect and molecular regulatory mechanism of A Disintegrin and Metalloproteinase 8 (ADAM8) were explored in alcoholic liver fibrosis (ALF). C57BL/6N male mice were randomly divided into control, alcohol, and ADAM8-sgRNA3 plasmid groups. The control group received control liquid diet, while the alcohol and ADAM8-sgRNA3 plasmid groups were given alcohol liquid feed diet combined with ethanol gavage treatment for 8 weeks to induce ALF modeling. In addition, the ADAM8-sgRNA3 plasmid group was injected with the effective ADAM8-sgRNA3 plasmid, while the alcohol and control group mice were injected with an equivalent amount of physiological saline. LX-2 human hepatic stellate cells were divided into control, alcohol, si-ADAM8-2, and si-ADAM8-NC groups and induced for 48 h for model establishment in vitro. Serological detection, pathological staining, Western blotting, qRT-PCR and CCK8 assay were performed for experiments. Compared with the alcohol group, ADAM8 mRNA, protein and, positive area rate, serological indicators, pathological changes, and the expression of liver fibrosis marker and MAPK signaling pathway-related factors in the ADAM8-sgRNA3 plasmid group significantly decreased in vivo. Compared with the alcohol group, ADAM8 mRNA and protein expression, cell viability, and the expression of liver fibrosis markers and MAPK signaling pathway-related factors (p-ERK1/2, PCNA, Bcl-2, p-c-Jun, TGFβ1, p–p38 MAPK and HSP27) reduced significantly in the si-ADAM8-2 group. Therefore, ADAM8 promotes ALF through the MAPK signaling pathway, a promising target for treating ALF.