Abstract Development of medicines and vaccines for COVID-19 amplified the need for all US communities to participate in research. This recognition spurred interest in adopting inclusive and equitable research practices across industry and the clinical research ecosystem in general. Between 2018-2021, regulatory bodies, professional organizations, and working groups issued policy and/or recommendations outlining measures that support the conduct of inclusive and equitable clinical trials. We applied previously published multi-themed strategies, multi-stakeholder recommendations, and calls to action by surveying industry to document baseline practices towards equitable clinical trial representation in the US. Research Question: What strategies are industry leaders deploying to increase diversity in clinical trials? Methods: Using a 4-staged approach, we first identified 48 success factors sourced from 12 documents. This analysis included previously documented measures that are both inclusive of diverse populations as well as practices that facilitate insights from diverse communities. Second, a survey tool was developed that organized the individual success factors into 6 categories with one open-ended question on ecosystem changes; survey measures and 4 choices for each factor were âActively implementing,â âRecommended to be implemented,â âNo plans to implement,â and âNo answer.â Third, the survey was administered between April 10-30, 2021, to 12 pharmaceutical companies all having a proven external commitment to health equity in oncology and all are represented on the 2021 1Q Biopharma top 25 by Market Cap report. Fourth, responses were anonymized and aggregated; results were provided to respondents. Results: The response rate was 67% (8/12). Responders indicated success factors across two major implementation categories as follows: âactively implementedâ (51%); ârecommended/planned for implementationâ (44%). No responders added any additional success factors via free text. Being âactively implementedâ was highest for the 3 categories âsite selectionâ (78%), âgeneral capabilitiesâ (72%), âleadershipâ (53%). âRecommended/planned for implementationâ was highest for the 3 categories âparticipant focusedâ (50%), âother factorsâ (50%), âracial and ethnic minority group data (REMG)â (48%). Conclusions: Pharmaceutical companies reported active implementation of success factors sourced from public documents across all categories. As an example, stakeholders have generally considered thoughtful site selection an important measure to enroll diverse representation in clinical trials as it may mitigate access barriers to participation. In the site selection category, the survey reported 7/8 companies were actively implementing three measures and 5/8 were actively implementing two measures. An approach and analysis should be considered for expansion to more biotech companies and include a process devised for annual fielding and transparently reporting results. Citation Format: Jeanne M. Regnante, Lola Fashoyin-Aje, Ellen Miller Sonet, Quita Highsmith, MBA, Melissa Gonzales, PhD, Sandra Amaro, MBA, Amy Davis, Mary Stober Murray, Maimah Karmo, Barbara Bierer. The pharmaceutical industry in action: 2021 clinical research diversity and inclusion survey [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-084.