Sustainability is achieved only when there is full reconciliation between: (1) economic development; (2) meeting, on an equitable basis, growing and changing human needs and aspirations; and (3) conserving the limited natural resources and the capacity of the environment to absorb the mulitple stresses that are a consequence of human activities. The linkages between climate and sustainability are examined in the context of both the wider Asia-Pacific region and local level climate risks and adaptation responses. These findings are used to underpin and illustrate several implications for sustainability science. Climate change is seen as both an impediment to increasing sustainability and as an opportunity, though in most cases the former far outweighs the latter. Assessments of climate change vulnerability and risk are shown to be of critical importance because they inform decisions as to where resources for adaptation are best invested. They also show whether global efforts to reduce greenhouse gas emissions need to be strengthened because of limits to adaptation. In practice, adaptation takes place at many levels, essentially ranging between tangible interventions at community and enterprise level and national and international efforts to strengthen the enabling environment for adaptation. It is informative to undertake regional assessments of adaptation, even though most adaptation interventions need to reflect local conditions, including local adaptive capacities. The foregoing findings, based in part on a series of regional and local case studies, lead to several recommendations for further research that will help reduce barriers to implementing responses that reduce climate related risks, including adverse consequences for sustainability. The recommendations relate to such themes as making optimum use of predictive capabilities, characterising the linkages between climate change and sustainability, implications of the required rates and magnitudes of adaptation, institutional responses that enhance adaptive capacity, use of new and traditional technologies, the multiple dimensions of social responsibility, and enhancing the enabling environment for adaptation at the community and enterprise level. If these recommendations are acted upon they will, in turn, help address much needed improvements in quantifying the costs and benefits of adaptation, prioritising adaptation options, assessing sustainable development tradeoffs, and monitoring the success of adaptation initiatives. Such improvements will have even greater utility if they are incorporated into user-friendly decision support tools for adaptation.