In the field of life science there is a growing awareness of the metaphorical tenor of many of its key concepts and the problems that arise from them, as in the now-controversial case of the genetic ‘program’. In the seminar Life Death (2019) Derrida addresses this question from Georges Canguilhem’s difficulties in establishing a clear distinction between metaphor and concept, precisely with regard to the notion of ‘program’, concluding that this difficulty ‘demand[s] a recasting of this division and of the law of this division’ between metaphor and concept. Beginning with these pages from Life Death, the present essay aims to reconstruct the deconstruction of this opposition and its epistemological consequences by going back to the Derridean essay ‘White Mythology’ (1971), to which Derrida refers in the seminar and in which the question of metaphor in the life sciences had been addressed in a critical confrontation with Bachelard and Canguilhem.