Course Of Episode Research Articles

In situ characterisation of pathogen dynamics during a Pacific oyster mortality syndrome episode

Significant mortality of Crassostrea gigas juveniles is observed systematically every year worldwide. Pacific Oyster Mortality Syndrome (POMS) is caused by Ostreid Herpesvirus 1 (OsHV-1) infection leading to immune suppression, followed by bacteraemia caused by a consortium of opportunistic bacteria. Using an in-situ approach and pelagic chambers, our aim in this study was to identify pathogen dynamics in oyster flesh and in the water column during the course of a mortality episode in the Mediterranean Thau lagoon (France). OsHV-1 concentrations in oyster flesh increased before the first clinical symptoms of the disease appeared, reached maximum concentrations during the moribund phase and the mortality peak. The structure of the bacterial community associated with oyster flesh changed in favour of bacterial genera previously associated with oyster mortality including Vibrio, Arcobacter, Psychrobium, and Psychrilyobacter. During the oyster mortality episode, releases of OsHV-1 and opportunistic bacteria were observed, in succession, in the water surrounding the oyster lanterns. These releases may favour the spread of disease within oyster farms and potentially impact other marine species, thereby reducing marine biodiversity in shellfish farming areas.

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Environmental context Aerosol acidity, or aerosol aqueous phase pH, can affect various environmental processes. Based on high frequency measurements of particulate compositions, along with thermodynamic calculations, this work studies particle acidity in the course of severe episodes of haze in Shanghai and considers the effect of this on the production of nitrate. The results will provide new perspectives on our interpretation of PM2.5 acidity during haze episodes in megacities. Abstract Aerosol acidity is one of the most important parameters that can influence climate change and human health, which has been inadequately analysed in China. Here, hourly measurements of particulate compositions and the E-AIM II model (assuming thermodynamic equilibrium) were used to study particle acidity during severe episodes of haze in Shanghai. The total concentration of sulfate, nitrate and ammonium was 138.9 ± 50.6 μg m−3, maximum 241.3 μg m−3; and the PM2.5 to PM10 (PM2.5/PM10) ratio was 0.60. The fine particles detected were somewhat acidic, with a pH range of 0.04–4.50, average 2.34, which is higher than in some areas of the US and China. The relatively low particle acidity is attributed to particle water content levels. Furthermore, the growth rate of sulfate, nitrate and ammonium during a haze episode (Case 2) was faster than that during a clean episode (CE), owing to exacerbated effects of PM2.5 acidity in the event of high relative humidity (RH) on hazy days. Finally, the detected significant correlations of [NO3−]/[SO42−] with [NH4+]/[SO42−] in conditions of abundant NH4+ indicate that NO3− in Shanghai is primarily formed through homogeneous reaction between ambient NH3 and HNO3. These findings provide new perspectives on our interpretation of PM2.5 acidity during haze episodes in megacities.

Neurocognitive functioning in bipolar disorder: What we know and what we don't.

Introduction: This narrative review of systematic reviews and meta-analyses aims at compiling available evidence in various aspects of neurocognitive functioning in Bipolar Disorder (BD).Methods: We conducted a MEDLINE literature search and identified 38 relevant systematic reviews and metaanalyses.Results: Current evidence suggests that BD is associated with cognitive impairment across multiple domains and during all clinical states. However, there is a considerable cognitive heterogeneity within BD, which cannot be explained by clinical subtypes, and the pattern of neurocognitive impairment in BD overlaps with other psychiatric conditions such as major depression and schizophrenia. Residual depressive symptoms, poor clinical course and higher number of manic episodes may negatively impact cognitive performance, which is a major predictor of general functioning in BD. Evidence from available prospective studies does not support the notion of progressive cognitive decline in BD while some evidence exists to suggest patients may show some improvements in cognitive functioning following the first manic episode. Furthermore, a subset of patients may show premorbid cognitive abnormalities that could signal an early neurodevelopmental aetiology. Preliminary findings from small studies identify potential pro-cognitive effects of Cognitive Remediation, erythropoietin, intranasal insulin, lurasidone, mifepristone, repetitive Transcranial Magnetic Stimulation and transcranial Direct Current Stimulation in BD.Discussion: Longitudinal studies in high-risk individuals can provide a better understanding of the development and progression of neurocognitive impairment in BD. Largescale randomised control trials are needed to compare the pro-cognitive efficacy of various pharmacological and non-pharmacological interventions in different cognitive subgroups of patients at different stages of BD.

MODERN SCIENTIFIC VIEWS ON THE CLINIC, SYSTEMATICS, DIAGNOSIS AND PATHOPERSONALOGY OF ENDOGENOUS PSYCHOSIS WITH EPISODIC COURSE (LITERATURE RIVIEW)

The aim of the study. To study the literature in order to identify modern scientific views on the clinic, systematics, diagnosis and pathopersonalogy of endogenous psychoses with episodic course. Results. The analysis of the literature shows that the diagnostic and classification approaches of endogenous psychoses with episodic course, are focused on polymorphic and variable symptoms of exacerbation of the disease. This leads to diagnostic mistakes, errors in the appointment of maintenance therapy, deterioration of compliance and further deepening of social maladaptation of patients. Refusal to develop the mechanisms of pathogenesis on the basis of the nosological approach will inevitably lead to a regression of the level of treatment and rehabilitation approaches - from ethiopathogenetic to symptomatic. Conclusions. Thus, at present, the importance of diagnostic techniques aimed at assessing and differentiating persistent symptoms of the disease in the period of remission of endogenous psychoses and relate to pathopersonalogical transformations. Research and correct diagnostic assessment of this multicomponent cluster of psychopathological symptoms allows to assess the nosological affiliation of a particular clinical case and to determine the necessary pharmacological and social rehabilitation effects in order to correct existing pathopersonalogical transformations and prevent exacerbation of endogenous psychosis.

A INFERÊNCIA À MELHOR EXPLICAÇÃO COMO HEURÍSTICA PARA ABORDAR EPISÓDIOS HISTÓRICOS NO ENSINO DE CIÊNCIAS POR MEIO DE CONTROVÉRSIAS EXPLICATIVAS

Este artigo propõe usar a Inferência à Melhor Explicação (IME) como forma de abordar aspectos da natureza da ciência, por meio de controvérsias explicativas históricas. A Inferência à Melhor Explicação é um tema de discussão na epistemologia que aborda a justificação e racionalidade do conhecimento. Seu foco é o estudo das condições que levaram uma explicação a ser considerada superior a suas concorrentes em um contexto específico. Neste trabalho, essa perspectiva é adaptada para analisar o conflito entre explicações científicas em momentos específicos da história da ciência. O foco é problematizar os fundamentos epistêmicos e culturais que sustentaram a defesa de explicações propostas ao longo do curso do episódio histórico sob discussão. Um dos objetivos é que essa discussão possa ser feita em contextos como a educação básica e a formação de professores, de modo a evitar as posições extremas da oposição entre concepções estruturalistas e relativistas sobre a ciência. Para isso, são apresentados alguns conceitos-chave da IME, seguida de uma proposta de como adaptá-los para o uso em contexto educacional. A título de ilustração, a perspectiva é empregada ao episódio histórico da explicação do efeito fotoelétrico, durante as primeiras décadas do século XX. No episódio em questão, são abordadas questões como: o papel da comunidade científica na avaliação do conhecimento científico, a indeterminação das teorias científicas pelas evidências disponíveis, e a influência de interesses pessoas na avaliação de teorias científicas.

The active layer in gravel‐bed rivers: An empirical appraisal

AbstractThe vertical position of the streambed–water boundary fluctuates during the course of sediment transport episodes, due to particle entrainment/deposition and bedform migration, amongst other hydraulic and bedload mechanisms. These vertical oscillations define a topmost stratum of the streambed (i.e. the ‘active layer or active depth’), which usually represents the main source of particles entrained during long and high‐magnitude bedload transport episodes. The vertical extent of this layer is hence a capital parameter for the quantification of bedload volumes and a major driver of stream ecology in gravel‐bed rivers. However, knowledge on how the active depth scales to flow strength and the nature of the different controls on the relation between the flow strength and the active depth is still scarce. In this paper we present a meta‐analysis over active depth data coming from ~130 transport episodes extracted from a series of published field studies. We also incorporate our own field data for the rivers Ebro and Muga (unpublished), both in the Iberian Peninsula. We explore the database searching for the influence of flow strength, grain size, streambed mobility and channel morphology on the vertical extent of the active layer. A multivariate statistical analysis (stepwise multiple regression) confirms that the set of selected variables explains a significant amount of variance in the compiled variables. The analysis shows a positive scaling between active depth and flow strength. We have also identified some links between the active depth and particle travel distances. However, these relations are also largely modulated by other fluvial drivers, such as the grain size of the bed surface and the dominant channel macro‐bedforms, with remarkable differences between plane‐bed, step‐pool and riffle‐pool channels. © 2020 John Wiley & Sons, Ltd.

Initial goals, goal trajectories, and changes in perceived resolvability during serial arguments

AbstractThis study examined how dyadic patterns of goal importance during a serial argument interaction predict changes in perceptions of argument resolvability over the course of a specific episode. Seventy romantic couples engaged in a 7‐min discussion of a current serial argument and used a video‐assisted recall method to report their goals at each minute. Although arguers' initial goals did not predict changes in perceptions of resolvability, increases in a partner's endorsement of partner‐identity goals predicted increases in individuals' own perceptions of resolvability. Conversely, increases in a partner's endorsement of self‐identity goals predicted declines in individuals' perceived resolvability. Results suggest that trajectories of identity‐focused goals during serial argument episodes may shape the progress of argument perceptions toward or away from resolvability.

Psychotic disorders in young adults with perinatally acquired HIV: a UK case series.

Increasing numbers of children with perinatally acquired HIV (PaHIV) are transitioning into adult care. People living with behaviourally acquired HIV are known to be at more risk of psychosis than uninfected peers. Young adults living with PaHIV face numerous risk factors; biological: lifelong exposure to a neurotrophic virus, antiretroviral medication and immune dysfunction during brain development, and environmental; social deprivation, ethnicity-related discrimination, and migration-related issues. To date, there is little published data on the prevalence of psychotic illness in young people growing up with PaHIV. We conducted a retrospective case note review of all individuals with PaHIV aged over 18 years registered for follow up at a dedicated clinic in the UK (n = 184). In total, 12/184 (6.5%), median age 23 years (interquartile range 21-26), had experienced at least one psychotic episode. The presentation and course of the psychotic episodes experienced by our cohort varied from short-lived symptoms to long term illness and nine (75%) appear to have developed a severe and enduring mental illness requiring long term care. The prevalence of psychosis in our cohort was clearly above the lifetime prevalence of psychosis in UK individuals aged 16-34 years, which has been reported to be 0.5-1.0%. This highlights the importance of clinical vigilance regarding the mental health of young people growing up with PaHIV and the need to integrate direct access to mental health services within the HIV centres providing medical care.

From Stress to Depression: Bringing Together Cognitive and Biological Science

One of the most consistent findings in the depression literature is that stressful life events predict the onset and course of depressive episodes. Cognitive and biological responses to life stressors have both been identified, albeit largely independently, as central to understanding the association between stress and depression. I maintain that the largest advances in the understanding of depression will come from examining the ways that cognitive and biological responses to stressors reciprocally influence one another and, in doing so, contribute to the onset and maintenance of depression. I summarize the cognitive and biological stress responses implicated in depression and then describe the reciprocal ways that they are associated with each other. Finally, I discuss the broader implications of taking this integrated approach and suggest directions and considerations for future research.

Trajectories of symptoms and healthcare use following respiratory tract infections in rural Anhui, China：a cross-sectional study

BackgroundRespiratory tract infections (RTIs) are important health problems with high incidence and consequent economic costs. The study aimed to analyze trajectories of experienced RTI symptoms and use of healthcare and antibiotics. MethodThe study adopted a cross-sectional design and face-face interview using a structured questionnaire. The questionnaire comprised: a) social demographics; b) last episode of symptomatic RTIs; c) responses to the RTIs; d) antibiotics obtained from clinics and medicine shops for the RTIs. The study subjects were residents in randomly selected villages in Anhui, China. The study settings were the residents households. Descriptive analyses were conducted to draw symptoms trajectory and identify relationship between healthcare seeking and symptoms and common sociodemographic variables. ResultA total 91.1% (1968) of 2160 eligible residents completed the interview who reported 1.83 episodes of RTIs in the pass year on average. Over half (54.8%) of these RTI episodes had led to visit to clinics for professional care and 51.9%, to use of antibiotics. The trajectories of common RTI symptoms featured a sharp increase and peak followed by a long tail along the days after onset of the infection. Over 60.5% of healthcare-seeking happened between two days before and one day after the symptoms peak. The study also revealed interesting pattern in the timing of different type of treatment following, e.g., taking leftover medicine and antibiotics happened the earliest and seeking professional help and getting antibiotics from clinics, the latest. ConclusionRTIs incur a large volume of healthcare-seeking and antibiotics use and there is an urgent need for effective education measures on proper service especially antibiotics use. Patients’ reported RTI symptoms manifest peculiar trajectories and their retrospective recall of the course of prior RTI episodes and associated actions may guide their future responses to similar infections. Knowledge of these may help inform doctors about patient expectations, enabling them better manage shared decision- making around antibiotic treatment.

Glutamate Level’s in Blood Serum of Patients with Schisophrenic Spectrum and Bipolar Affective Disorder

The objective: the involvement of glutamatergic neurotransmitter systems in the pathogenesis of schizophrenic spectrum disorders and BD has been repeatedly proven. But today, there are no methods available to evaluate the glutamate metabolism in patients with mental disorders. The paper presents differences in the level of glutamate in the blood serum of patients with a schizophrenic spectrum disorder, bipolar disorder, and healthy individuals.Patients and methods: the study included 224 people. 179 patients were presented with paranoid schizophrenia, simple schizophrenia, schizotypal disorder, acute polymorphic disorder, schizoaffective disorder and BD.Results: in this work shows that the level of glutamate in patients in all studied groups is statistically significantly higher than in healthy individuals, except for acute polymorphic psychotic disorder. Serum glutamate concentration in patients with schizotypal disorder is 1.6 times higher than in healthy individuals. The significant differences in glutamate levels were detected in patients with schizotypal disorder and OCD (p = 0.045), and patients with paranoid schizophrenia (p = 0.012). The concentration of glutamate is also increased in patients with simple schizophrenia compared to patients with paranoid schizophrenia (p = 0.039). In addition, it was observed a glutamate increase in healthy individuals compared in patients with a continuous course of schizophrenia (p = 0.001), in patients with an episodic course with progressive deficit (p = 0.0211) and in patients with a schizophrenia duration of more than 12 years.Conclusions: thus, the concentrations of glutamate in the blood serum of patients are depending on the severity of the course of schizophrenia and maybe an additional paraclinical criterion for the diagnosis of schizotypal disorder.

Erenumab in highly therapy-refractory migraine patients: First German real-world evidence

BackgroundCalcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding efficacy and tolerability of erenumab in highly therapy-refractory patients are not available, yet, although many patients treated with CGRP mAB under real world conditions can be considered as highly therapy-refractory.MethodsClinical routine data of highly therapy-refractory migraine patients treated with erenumab 70 mg for 3 months between November 2018 and December 2019 in the West German Headache Center, University Hospital Essen, Germany, were analysed. Monthly migraine days (MMD), monthly headache days (MHD) and days of acute medication intake (AMD) were assessed. Statistical analysis was performed using the Wilcoxon test. Descriptive statistics were performed to evaluate changes of vegetative symptoms, acute medication response, side effects, as well as treatment satisfaction.ResultsComplete clinical data were available for 26 episodic (EM) and 74 chronic (CM) migraineurs. Sixty-six % (n = 49) of CM patients had an additional medication overuse headache (MOH). After 3 months 57.7% of EM patients and 41.9% of CM patients had a 50% or greater reduction of MMD. The mean number of MMD was reduced by 3.43 (SE 1.26) in EM, and by 4.72 (SE 0.87) in CM. Thirty-nine patients (52.7%) returned from chronic to episodic course of migraine. After 3 months, 23 patients (46.9%) were not suffering from a MOH anymore.ConclusionsErenumab seems to be a promising therapeutic option in highly therapy-refractory migraine patients.Trial registrationRetrospective registered.

Medication adherence and its correlates among patients affected by schizophrenia with an episodic course: A large-scale multi-center cross-sectional study in China.

The Medication Adherence Rating Scale (MARS) is a fast, non-intrusive way of measuring adherence to medication in order to improve the management of patients with schizophrenia. The current cross-sectional study evaluated the reliability of the Chinese (Mandarin) version of the MARS and explored clinical and demographic correlates to medication adherence in a large sample of patients affected by schizophrenia with an episodic course in China. 1198 patients were recruited from 37 different hospitals in 17 provinces/municipalities of China and evaluated with the Medication Adherence Rating Scale (MARS), Clinical Global Impression-Severity of Illness (CGI-SI) and Sheehan Disability Scale-Chinese version (SDS-C). The MARS showed good internal consistency; Cronbach's alpha of total MARS was 0.83. Among the cohort of patients affected by schizophrenia with an episodic course, 28.5 % met the criteria of good adherence to antipsychotic medication; age, steady income, and severity of illness had significant effects on medication adherence. Medication adherence of patients affected by schizophrenia in mainland China was found to be relatively low, calling for urgent attention and intervention. Risk factors for non-adherence to medication among patients affected by schizophrenia with an episodic course include older age, unsteady income, being in the acute period of the disease, and severity of illness.

Changes of white matter microstructure after successful treatment of bipolar depression

BackgroundDiffusion tensor imaging (DTI) measures suggest a widespread alteration of white matter (WM) microstructure in patients with bipolar disorder (BD). The chronotherapeutic combination of repeated total sleep deprivation and morning light therapy (TSD+LT) can acutely reverse depressive symptoms in approximately 60% of patients, and it has been confirmed as a model antidepressant treatment to investigate the neurobiological correlates of rapid antidepressant response. MethodsWe tested if changes in DTI measures of WM microstructure could parallel antidepressant response in a sample of 44 patients with a major depressive episode in course of BD, treated with chronoterapeutics for one week. We used both a tract-wise and a voxel-wise approach for the whole-brain extraction of DTI measures of WM microstructure: axial (AD), radial (RD), and mean diffusivity (MD), and fractional anisotropy (FA). ResultsCompared to baseline level, at one-week follow up we observed a significant increase in average FA measures paralleled by a significant decrease in MD measures of several WM tracts including cingulum, corpus callosum, corona radiata, cortico-spinal tract, internal capsule, fornix and uncinate fasciculus. The degree of change was associated to clinical response. ConclusionsThis is the first study to show changes of individual DTI measures of WM microstructure in response to antidepressant treatment in BD. Our results add new evidence to warrant a role for chronotherapeutics as a first-line treatment for bipolar depression and contribute identifying generalizable neuroimaging-based biomarkers of antidepressant response.

An algorithm for the diagnostic differentiation of schizoaffective disorder and other endogenous psychoses with episodic course (schizophrenia and affective disorders)

At present, it is difficult to carry out differential diagnosis between schizophrenia, schizoaffective disorder (SAD) and affective disorders (AD), which is caused by a similarity of the clinical features of psychosis exacerbation. A promising direction of improving the quality of differential diagnosis is the study of nosospecific pathopersonological transformations (PpT). Studying of these changes and identifying their clinical differences from the pathopersonology of schizophrenia and AD will allow differential diagnosis with a high level of confidence.The aim of the study was to develop an algorithm for the diagnostic differentiation of SAD and other endogenous psychoses with episodic course (schizophrenia and AD) based on the analysis of clinical-psychopathological, medical- psychological and clinical-ethological features of remission.Contingents and methods. 312 patients were examined at the Municipal Non-Commercial Enterprise “Regional Clinical Institution for Provision of Psychiatric Care” of Zaporizhzhia Regional Council, including 102 patients suffering from AD, 102 persons with SAD and 108 patients diagnosed with “Schizophrenia. Paranoid type. Episodical course”.The main methods of the study were clinical-psychopathological, psychodiagnostical, pathopsychological, clinical-anamnestical, clinical-ethological, as well as medical-statistical analysis.Results. The study developed an algorithm for the diagnostic differentiation of SAD and other endogenous psychoses with episodic course (schizophrenia and AD) based on the analysis of clinical-psychopathological, medical-psychological and clinical-ethological features of remissions / intermissions.The algorithm involves the sequential use of 2 tables (differentiation for the pair of SAD – schizophrenia and SAD – AD), which included features, sorted by decreasing total informative index.Conclusions. The results obtained can be used in the differential diagnosis of endogenous psychosis with the determination of nosological affiliation of the clinical case to the SAD and for use of individually required medico-rehabilitative interventions.

Detection and intervention in emerging youth mental health issues: Outcomes from the first year of the CASPAR service.

There is a recognized gap in mental health service provision for youth, a population in whom emerging mental disorders are prevalent and recognized as a target for early intervention. Comprehensive Assessment Service for Psychosis and At-Risk (CASPAR) is a new, community-based service aiming to address the service gap between headspace and tertiary psychiatric services. CASPAR facilitates assessment and short-term early intervention in youth (aged 12-25 years) with emerging mental health issues. Demographic and clinical characteristics are described in all individuals receiving care from CASPAR in its first year of operation. Changes in psychological distress and psychosocial functioning over the course of a treatment episode are reported. Demographic and clinical data, including measures of functional impairment (Social and Occupational Functioning Assessment Scale [SOFAS]) and psychological distress (Kessler Psychological Distress Scale [K10]), were obtained at baseline and completion of episode of care for all clients. 92 young people (53.3% male, mean age 18.7 years) were included, of whom 20 (21.7%) disengaged before treatment endpoint. Clients who disengaged early were more likely to identify as lesbian, gay, bisexual and transgender+ (LGBT+). At follow-up, 61.1% showed improvements in social functioning (SOFAS) and 64.4% in psychological distress (K10). The majority of clients showed improvements in psychological distress and functioning during an episode of care. LGBT+ youth were less likely to remain engaged with the service. The factors associated with initial and continued engagement with youth early intervention services require further examination, particularly in marginalized groups with high mental illness prevalence such as LGBT+ communities.

Action repertoires in contentious episodes: What determines governments’ and challengers’ action strategies? A cross‐national analysis

AbstractThis paper studies the interactions between governments, challengers and third party actors in the context of 60 contentious policy episodes in 12 European countries during the Great Recession. More specifically, we focus on the endogenous dynamics that develop in the course of these episodes. Based on the combination of a new event dataset, which allows for the construction of action sequences, and a novel method (contentious episode analysis) to study the impact of actor‐specific actions on subsequent actions within a sequence, we test a set of hypotheses on the determinants of actors’ overall action repertoires within specific contexts. Overall, our results are more supportive of the interdependence of cooperation than of the interdependence of conflict: the repression‐radical mobilisation‐external legitimation of conflictive behaviour nexus is weaker than the concession‐cooperation‐mediation nexus. While the literature tends to focus on conflict dynamics, we find that there is a more systematic dynamics of cooperation in the course of contentious episodes.

Early pubertal timing predicts onset and recurrence of depressive episodes in boys and girls.

Recurrent depressive episodes during adolescence result in significant impairment and increased risk for subsequent adverse outcomes throughout the life span. Evidence suggests that early pubertal timing predicts the onset of depressive episodes (particularly for girls); however, it is not known if pubertal timing prospectively predicts recurrent depressive episodes in youth. At baseline, 603 youth (56% female, at baseline: Mage =12.09, SD=2.35) reported on their pubertal development. Youth and their parents completed a semistructured diagnostic interview to assess depressive episodes at baseline and then evaluated for onset repeatedly every 6months for a period of 36months. Controlling for past history of depression, Cox proportional hazards models examined whether earlier pubertal timing predicted (a) days to first depressive episode from baseline and (b) days to a second (recurrent) depressive episode from the end of the first episode. Early pubertal timing predicted the onset of the first depressive episode after baseline (b=.19, Wald=5.36, p=.02, HR=1.21), as well as a recurrent episode during course of study follow-up episode (b=.32, Wald=6.16, p=.01, HR=1.38). Findings reinforce the importance of considering the impact of early pubertal timing on depression risk. Investigation on how pubertal timing interacts with other risk factors to predict depression recurrence is needed.

Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis

Generalized pustular psoriasis (GPP) represents a rare pustular disease manifesting as a multisystemic inflammation in a chronic or episodic course, sometimes as life-threatening incidents. Biallelic IL36RN mutations are known to be disease-causing or -contributing in 21–41% of patients with GPP (Hussain et al., 2015; Marrakchi et al., 2011; Mössner et al., 2018; Onoufriadis et al., 2011; Sugiura et al., 2013). IL-36 binds to the IL-36 receptor complex, thereby triggering the activation of mitogen-activated protein kinase and NF-κB, resulting in the production of proinflammatory cytokines.

Characteristics of personality in patients with endogenous psychoses with an episodicаl course in the context of post-manifest pathopersonаlogical transformations (comparative analysis)

Solution of the problems of differential diagnosis, treatment and social rehabilitation of patients with endogenous psychoses with episodic course is one of the most complex and urgent problems of clinical psychiatry, which is caused by polymorphism and variability of symptoms, decrease or loss of critical attitude toward the disease, with grave social and economic consequences. The aim of the study is to establish, on the basis of the results of the comparative analysis of the characteristics of the personal profile, the features and nosospecific differences of post-manifest pathopersonаlogical transformations in patients with schizophrenia, schizoaffective disorder and affective disorders in remission / intermissions. The study examined the personality characteristics of endogenous psychoses with an episodic course in remission / intermission conditions and established signs and nosospecific differences in post-manifest pathological transformations in patients with schizophrenia, schizoaffective disorder, and affective disorders. Existing pathopersonalogical transformations are characterized by signs of multidirectional tendencies of compensatory tension of personal resources, which is confirmed by the presence of several moderately elevated (65-75 T-points) indicators of individual scales and a simultaneous increase in indicators of both hyposthenic (2nd and 7th scales) and hypersthenic ( 4th and 9th scales) registers. In schizoaffective disorder, such scales are the 2nd (65.36±12.28 T-points), 4th (73.23±11.83 T-points), 8th (68.40±12.33 T-points) and 9th (66.05±12.02 T-points); in affective disorders, these are the 2nd, 4th and 8th scales (67.72±13.96, 67.08±9.53 and 65.90±10.08 T-points, respectively); for schizophrenia, such scales are the 2nd (72.37 ± 16.80 T-points), 4th (69.47±12.48 T-points), 7th (66.59±15.69 T-points) ) and 8th (71.73±19.95 T-points). The obtained data can be used as a component of the differential diagnosis system and personified psychotherapeutic support.