Episodic Autobiographical Memory Research Articles

Nonepisodic autobiographical memory details reflect attempts to tell a good story.

A persistent finding in the autobiographical memory (AM) literature is that older adults report more nonepisodic (or generalized/semantic) information than young adults. Since studies are usually focused on memory for episodic (or specific) autobiographical events, the reason for the age difference in nonepisodic AM remains understudied. This experiment investigated whether the higher rate of nonepisodic AM in older adults reflects (a) a difference incommunicative preferences or (b) cognitive decline, by way of either an inhibition deficit or as a means of compensating for a deficit in episodic AM. A sample of 54 young (N = 28, age range = 18-46) and older (N = 26, age range = 62-86) participants retrieved the same AM twice, under two different sets of instructions: to tell a good story for their autobiography, or to provide a detailed police witness statement. Both groups reported more general details when they were aiming to tell a good story. In addition, older adults also reported fewer specific details when the aim was to tell a good story. In a separate ranking task, young and older adults differed in their perceptions of what makes a good story; young adults ranked "detail," "grammar," and "full descriptions" more highly than older adults, whereas older ranked "linking ideas" and "explaining not just describing" more highly than young adults. The results suggest that age-related differences in nonepisodic AM might be explained by communicative preferences rather than cognitive decline. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The formation of episodic autobiographical memory is predicted by mental imagery, self-reference, and anticipated details.

Despite the ecological nature of episodic memory (EM) and the importance of consolidation in its functioning, studies tackling both subjects are still scarce. Therefore, the present study aims at establishing predictions of the future of newly encoded information in EM in an ecological paradigm. Participants recorded two personal events per day with a SenseCam portable camera, for 10 days, and characterized the events with different subjective scales (emotional valence and intensity, self-concept and self-relevance, perspective and anticipated details at a month, mental images…). They then performed a surprise free recall at 5 days and 1 month after encoding. Machine learning algorithms were used to predict the future of events (episodic or forgotten) in memory at 1 month. The best algorithm showed an accuracy of 78%, suggesting that such a prediction is reliably possible. Variables that best differentiated between episodic and forgotten memories at 1 month were mental imagery, self-reference, and prospection (anticipated details) at encoding and the first free recall. These results may establish the basis for the development of episodic autobiographical memory during daily experiences.

Neural substrates of specific and general autobiographical memory retrieval in younger and older adults

Healthy aging is associated with a shift away from the retrieval of specific episodic autobiographical memories (AMs), towards more general and semanticized memories. Younger adults modulate activity in the default mode network according to the episodic specificity of AM retrieval. However, little is known about whether aging disrupts this neural modulation. In the current study we examine age-related changes in the modulation of whole-brain networks in response to three tasks falling along a gradient of episodic specificity. Younger and older adults retrieved specific (unique) AMs, general (routine) AMs, and semantic (general knowledge) memories. We found that both younger and older adults modulated default mode regions in response to varying episodic specificity. In addition, younger adults upregulated activity in several default mode regions with increasing episodic specificity, while older adults either did not modulate these regions, or downregulated activity in these regions. In contrast, older adults upregulated activity in the left temporal pole for tasks with higher episodic specificity. These brain activation patterns converge with prior findings that specific AMs are diminished in episodic richness with age, but are supplemented with conceptual and general information. Age-related reductions in the modulation of default mode regions might contribute to the shift away from episodic retrieval and towards semantic retrieval, resulting in reduced episodic specificity of personal memories.

Familiar olfactory stimulation related to self‐awareness in Alzheimer’s disease

AbstractBackgroundAlzheimer disease is extended everyday, Latinamerica is not an exception. Patients with AD have a decline about remembering events of general knowlage and past events about their life. Therefore episodic and semantic autobiographical memory is affected in patients with AD. This study shows how is that memory in Dominican Republic and Colombian Population. Also aim to see the difference after an olfactory stimulation with chocolate.MethodFifty people with mild and moderate A.D participated. The Control group, had an olfactory stimulation without familiar smell (placebo) and the experimental group, had an olfactory stimulation with familiar smell (chocolate). Before intervention post olfactory stimulation, of self‐consciousness, was made. After intervention an evaluation of autobiographical episodic memory and self‐consciousness was made. During intervention placebo stimulation with control group and an olfactory familiar stimulation with experimental group was incorporated. Afterwards, an evaluation of episodic autobiographical memory was conducted.ResultPreliminary results shows that patients with AD improves their episodic autobiographical memory.ConclusionThis findings shows a big impact for research because it will be a no farmacological trial that will help the patients with AD. Therefore it will be goood to their families, because it diminished the emotional impact of AD. Finally, will impacts the literature because is the first study in Caribbean region, a area in wich the research is not frequen because of the resources.

Spoken discourse in episodic autobiographical and verbal short-term memory in Chinese people with dementia: the roles of global coherence and informativeness.

Memory and discourse production are closely related in healthy populations. A few studies in people with amnestic mild cognitive impairment and people with dementia (PWD) suggested similar links, although empirical evidence is insufficient to inform emerging intervention design and natural language processing research. Fine-grained discourse assessment is needed to understand their complex relationship in PWD. Spoken samples from 104 PWD were elicited using personal narrative and sequential picture description and assessed using Main Concept Analysis and other content-based analytic methods. Discourse and memory performance data were analyzed in bivariate correlation and linear multiple regression models to determine the relationship between discourse production and episodic autobiographical memory and verbal short-term memory (vSTM). Global coherence was a significant predictor of episodic autobiographical memory, explaining over half of the variance. Both episodic autobiographical memory and vSTM were positively correlated with global coherence and informativeness, and negatively with empty speech indices. Coherence in personal narrative may be supported by episodic autobiographical memory and vice versa, suggesting potential mechanism of interventions targeting personhood through conversation. Indices of global coherence, informativeness, and empty speech can be used as markers of memory functions in PWD.

The autobiographical fluency task: Validity and reliability of a tool to assess episodic autobiographical memory and experience-near personal semantics.

The assessment of autobiographical memory is challenging in clinical settings. The Autobiographical Fluency Task (AFT) - that is designed to test both Episodic Autobiographical Memory (EAM) and experience-near Personal Semantics (enPS) - may represent a feasible and rapid method to test access to autobiographical memories. Here we tested the reliability and the construct validity of the AFT. A total number of 51 individuals participated in the present study, with 24 included in Experiment 1 and 27 in Experiment 2. In Experiment 1, participants performed both the AFT and the Survey of Autobiographical Memory (SAM). In Experiment 2, participants completed the AFT and the Autobiographical Interview (AI). The AFT showed a moderate-to-high reliability. Also, EAM and enPS scores significantly correlated with the episodic subscale of the SAM. Results of Experiment 1 were replicated and expanded in Experiment 2. Again, the AFT showed a high reliability. Both EAM and enPS showed a significant correlation with the number of internal details produced during the AI; enPS also correlated with the number of external details. Overall, the present results show that the AFT may be a feasible instrument to assess autobiographical memory, especially for testing episodic autobiographical memory and experience-near personal semantics in clinical settings.

H - 02 Unveiling the Effects of Bilingualism on Autobiographical Memory in Hispanics: Implications for Cognitive Aging.

Episodic autobiographical memory (EAM) may be particularly sensitive to age-related cognitive decline and risk for Alzheimer's disease. Virtually nothing is known about EAM specificity in Hispanic individuals. Bilingualism is a cognitive factor that may influence EAM specificity among Hispanics. The present study aimed to 1) examine if EAM is sensitive to age in Hispanics and 2) reveal whether bilingualism influences EAM specificity in Hispanics. A sample of 150 young and middle-aged/older adults (50 English-Spanish bilingual Hispanics; 50 monolingual English-speaking Hispanics; 50 monolingual English speaking Non-Hispanic Whites) narrated EAMs using the established Autobiographical Interview (Levine et al., 2002). Using the scoring protocol of the Autobiographical Interview, we evaluated the narratives for episodic and non-episodic detail. We replicated the often-found age-related reduction in episodic detail generation in Hispanics. Bilingual Hispanics' memories were more episodically specific than monolingual Hispanics and Non-Hispanic Whites. We also found that, among bilingual Hispanics, the language used at encoding versus language used at memory retrieval was not associated with episodic specificity. Our findings suggest that episodic autobiographical memory is sensitive to age and bilingualism in Hispanics, making it a culturally appropriate cognitive measure among this population.

Attentional switch to memory: An early and critical phase of the cognitive cascade allowing autobiographical memory retrieval.

Remembering and mentally reliving yesterday's lunch is a typical example of episodic autobiographical memory retrieval. In the present review, we reappraised the complex cascade of cognitive processes involved in memory retrieval, by highlighting one particular phase that has received little interest so far: attentional switch to memory (ASM). As attention cannot be simultaneously directed toward external stimuli and internal memories, there has to be an attentional switch from the external to the internal world in order to initiate memory retrieval. We formulated hypotheses and developed hypothetical models of both the cognitive and brain processes that accompany ASM. We suggest that gaze aversion could serve as an objective temporal marker of the point at which people switch their attention to memory, and highlight several fields (neuropsychology, neuroscience, social cognition, comparative psychology) in which ASM markers could be essential. Our review thus provides a new framework for understanding the early stages of autobiographical memory retrieval.

Episodic and Semantic Autobiographical Memory in Mild Cognitive Impairment (MCI): A Systematic Review.

Mild cognitive impairment (MCI) is a syndrome defined as a decline in cognitive performance greater than expected for an individual according to age and education level, not interfering notably with daily life activities. Many studies have focused on the memory domain in the analysis of MCI and more severe cases of dementia. One specific memory system is represented by autobiographical memory (AM), which has been largely studied in Alzheimer's disease and its effect on AM; however, the impairment of AM in moderate forms of decline, such as MCI, is still controversial. The main aim of this systematic review is to analyze the functioning of autobiographical memory in patients with MCI, considering both the semantic and the episodic components. The review process was conducted according to the PRISMA statement. The search was conducted until 20 February 2023 in the following bibliographical databases: PubMed, Web of Science, Scopus, and PsycInfo, and twenty-one articles were included. The results highlight controversial findings concerning the semantic component of AM since only seven studies have found a worse semantic AM performance in patients with MCI compared to the HC group. The results of impaired episodic AM in individuals with MCI are more consistent than those concerning semantic AM. Starting from the evidence of this systematic review, further studies should detect and investigate the cognitive and emotional mechanisms that undermine AM performance, allowing the development of specific interventions targeting these mechanisms.

What about "space" is important for episodic memory?

Early cognitive neuroscientific research revealed that the hippocampus is crucial for spatial navigation in rodents, and for autobiographical episodic memory in humans. Researchers quickly linked these streams to propose that the human hippocampus supports memory through its role in representing space, and research on the link between spatial cognition and episodic memory in humans has proliferated over the past several decades. Different researchers apply the term "spatial" in a variety of contexts, however, and it remains unclear what aspect of space may be critical to memory. Similarly, "episodic" has been defined and tested in different ways. Naturalistic assessment of spatial memory and episodic memory (i.e., episodic autobiographical memory) is required to unify the scale and biological relevance in comparisons of spatial and mnemonic processing. Limitations regarding the translation of rodent to human research, human ontogeny, and inter-individual variability require greater consideration in the interpretation of this literature. In this review, we outline the aspects of space that are (and are not) commonly linked to episodic memory, and then we discuss these dimensions through the lens of individual differences in naturalistic autobiographical memory. Future studies should carefully consider which aspect(s) of space are being linked to memory within the context of naturalistic human cognition. This article is categorized under: Psychology > Memory.

Confabulations in a teenager with a right frontal hemispherotomy: Possible underlying mechanisms

Objective: Confabulations, i.e. false memories without intention to deceive, can be observed in adults with frontal brain damage. Confabulations are typically associated with episodic memory and/or executive disorders although the severity of these impairments is highly variable. Confabulations may also be associated with emotional/motivational particularities, as a positive bias seems to prevail in such situations. Several distinct cognitive and socio-affective processes may account for the various types of confabulations and these issues remain open. Method: We present the case of a teenager with an early acquired frontal damage, referred for “strange lies.” Besides a standard neuropsychological assessment, we explored (1) source memory, using a reality-monitoring task, (2) episodic autobiographical memory, including both the recollection of the past memories and the ability to imagine future personal events, with an episodic future thinking task (EFT), (3) the sense of self, with questionnaires targeting self-representations, self-esteem and self-competence. Results: The results showed the expected source memory deficits and poor episodic future thinking, whereas episodic autobiographical memory was preserved, contrary to the episodic memory dysfunction usually evidenced in adult confabulators. The confabulations produced by this teenager displayed a clear positive bias, seemed to fit to personal/social goals and to wishful ideations, and were associated with an above average self-esteem and self-representation. Conclusions: These results support the hypothesis of self-identity and emotional regulatory roles of the confabulations. Although the literature on confabulating children/teenagers is nearly non-existent, a more systematic screening of confabulations should be conducted in order to avoid false interpretation to strange discourse or behavior.

Temporal Organization of Episodic and Experience-near Semantic Autobiographical Memories: Neural Correlates and Context-dependent Connectivity.

Autobiographical memory includes a representation of personal life events with a unique spatiotemporal context (episodic autobiographical memory) and factual self-knowledge (personal semantics). Whereas "experience-far" personal semantics have undergone complete abstraction, "experience-near" personal semantics are still linked to a spatiotemporal context. The representation of one's own past involves an autobiographical knowledge base, in the form of a personal timeline, along which autobiographical information is temporally organized into different lifetime periods. Commonalities and differences between brain networks supporting this temporal organization for autobiographical information with different contextual specificity, however, have not been investigated to date. Here, we used task-based fMRI to assess neural substrates of temporal ordering along the personal timeline for real autobiographical episodic and experience-near personal semantic memories. Within a distributed network, the left calcarine cortex was more strongly activated for episodic autobiographical memory than personal semantics, whereas the left ventromedial pFC and right posterior cingulate cortex (PCC), angular gyrus (AG), and anterior middle temporal gyrus (aMTG) showed stronger activation for personal semantics than episodic autobiographical memory. Findings were confirmed by analyses in independently derived ROIs. Generalized psychophysiological interaction analyses between the same regions showed that, during personal semantics compared with episodic autobiographical memory, memory category modulated activity in the left PCC and right PCC, AG, and aMTG. Findings provide insights on how personal events and facts are represented in the timescale of years, suggesting that the temporal organization of autobiographical memory exploits properties of situation models developed within posteromedial, lateral parietal, and medial prefrontal regions.

Aesthetic experience enhances first-person spatial representation

Episodic autobiographical memories are characterized by a spatial context and an affective component. But how do affective and spatial aspects interact? Does affect modulate the way we encode the spatial context of events? We investigated how one element of affect, namely aesthetic liking, modulates memory for location, in three online experiments (n = 124, 79, and 80). Participants visited a professionally curated virtual art exhibition. They then relocated previously viewed artworks on the museum map and reported how much they liked them. Across all experiments, liking an artwork was associated with increased ability to recall the wall on which it was hung. The effect was not explained by viewing time and appeared to modulate recognition speed. The liking-wall memory effect remained when participants attended to abstractness, rather than liking, and when testing occurred 24 h after the museum visit. Liking also modulated memory for the room where a work of art was hung, but this effect primarily involved reduced room memory for disliked artworks. Further, the liking-wall memory effect remained after controlling for effects of room memory. Recalling the wall requires recalling one's facing direction, so our findings suggest that positive aesthetic experiences enhance first-person spatial representations. More generally, a first-person component of positive affect transfers to wider spatial representation and facilitates the encoding of locations in a subject-centered reference frame. Affect and spatial representations are therefore important, and linked, elements of sentience and subjectivity. Memories of aesthetic experiences are also spatial memories of how we encountered a work of art. This linkage may have implications for museum design.

Effects of saccadic eye movements on episodic & semantic memory fluency in older and younger participants

ABSTRACT Research has demonstrated that performing a sequence of saccadic horizontal eye movements prior to retrieval facilitates performance on tests of episodic memory. This has been observed in both laboratory tasks of retention and autobiographical memory. To date, the work has centred on performance in younger individuals. This paper extends previous investigations by examining the effects of saccadic eye movements in older persons. Autobiographical episodic and semantic memory fluency was assessed in younger (age range 18–35, mean = 22.50), and older (age range 55–87, mean = 70.35) participants following saccadic (vs. fixation control) manipulations. The main effects of eye movements and age were found for episodic autobiographical memory (greater fluency after eye movements and in younger participants). Semantic autobiographical memory showed a main effect of age (greater fluency in younger participants), whereas general semantic memory showed no effect of age or eye movement. These findings indicate that saccadic horizontal eye movements can enhance episodic personal memory in older individuals. This has implications as a technique to improve autobiographical recollection in the elderly and as an adjunct in reminiscence therapy.

Behavioral, neurological, and psychiatric frailty of autobiographical memory.

Autobiographical-episodic memory is considered to be the most complex of the five long-term memory systems. It is autonoetic, which means, self-reflective, relies on emotional colorization, and needs the features of place and time; it allows mental time traveling. Compared to the other four long-term memory systems-procedural memory, priming, perceptual, and semantic memory-it develops the latest in phylogeny and ontogeny, and is the most vulnerable of the five systems, being easily impaired by brain damage and psychiatric disorders. Furthermore, it is characterized by its fragility and proneness to distortion due to environmental influences and subsequent information. On the brain level, a distinction has to be made between memory encoding and consolidating, memory storage, and memory retrieval. For encoding, structures of the limbic system, with the hippocampus in its center, are crucial, for storage of widespread cortical networks, and for retrieval again a distributed recollection network, in which the prefrontal cortex plays a crucial role, is engaged. Brain damage and psychiatric diseases can lead to what is called "focal retrograde amnesia." In this context, the clinical picture of dissociative or functional or psychogenic amnesia is central, as it may result in autobiographical-emotional amnesia of the total past with the consequence of an impairment of the self as well. The social environment therefore can have a major impact on the brain and on autobiographical-episodic memory processing. This article is categorized under: Psychology > Memory.

The Moral Impact of the COVID-19 Pandemic on Nurses' Burnout, Work Satisfaction and Adaptive Work Performance: The Role of Autobiographical Memories of Potentially Morally Injurious Events and Basic Psychological Needs.

The COVID-19 pandemic resulted in unprecedented exposure to Potentially Morally Injurious Events (PMIEs) for nurses, in which they were both moral transgressors and moral victims, with deleterious consequences on their psycho-social health and functioning. Our experimental design compared memories of PMIEs with memories of severe moral transgressions (SMTs), in which participants were only moral transgressors. Drawing from Self-Determination Theory and research on moral auto-biographical episodic memories, we assessed a conceptual model describing the impact of recalling a single PMIE or SMT event on nurses’ burnout, work satisfaction and adaptive performance. Our convenience sample comprised 614 Romanian nurses, and data was analyzed with path analysis, general linear modelling, and t-tests. Findings showed that memories of PMIEs, compared to SMTs, were more autonomy thwarting, being associated with more controlled work motivation, less moral learning, higher burnout, less work satisfaction, and adaptive performance. Burnout, moral learning, and work satisfaction were significant mediators of the relationships between PMIE and SMT recall and, respectively, adaptive performance. Our results highlight the urgency for organizational practices of moral repair for nurses after the pandemic, along with interventions meant to increase their autonomy and self-determined work motivation.

I remember therefore I am: Episodic memory retrieval and self-reported trait empathy judgments in young and older adults and individuals with medial temporal lobe excisions

How do we know what sort of people we are? Do we reflect on specific past instances of our own behaviour, or do we just have a general idea? Previous work has emphasized the role of personal semantic memory (general autobiographical knowledge) in how we assess our own personality traits. Using a standardized trait empathy questionnaire, we show in four experiments that episodic autobiographical memory (memory for specific personal events) is associated with people's judgments of their own trait empathy. Specifically, neurologically healthy young adults rated themselves as more empathic on questionnaire items that cued episodic memories of events in which they behaved empathically. This effect, however, was diminished in people who are known to have poor episodic memory: older adults and individuals who have undergone unilateral excision of medial temporal lobe tissue (as treatment for epilepsy). Further, self-report ratings on individual questionnaire items were generally predicted by subjectively rated phenomenological qualities of the memories cued by those items, such as sensory detail, scene coherence, and overall vividness. We argue that episodic and semantic memory play different roles with respect to self-knowledge depending on life experience, the integrity of the medial temporal lobes, and whether one is assessing general abstract traits versus more concrete behaviours that embody these traits. Future research should examine different types of self-knowledge as well as personality traits other than empathy.

Temporal pole volume is associated with episodic autobiographical memory in healthy older adults.

Recollection of personal past events differs across the lifespan. Older individuals recall fewer episodic details and convey more semantic information than young. Here we examine how gray matter volumes in temporal lobe regions integral to episodic and semantic memory (hippocampus and temporal poles, respectively) are related to age differences in autobiographical recollection. Gray matter volumes were obtained in healthy young (n = 158) and old (n = 105) adults. The temporal pole was demarcated and hippocampus segmented into anterior and posterior regions to test for volume differences between age groups. The Autobiographical Interview was administered to measure episodic and semantic autobiographical memory. Volume associations with episodic and semantic autobiographical memory were then assessed. Brain volumes were smaller for older adults in the posterior hippocampus. Autobiographical memory was less episodic and more semanticized for older versus younger adults. Older adults also showed positive associations between temporal pole volumes and episodic autobiographical recall; in the young, temporal pole volume was positively associated with performance on standard laboratory measures of semantic memory. Exploratory analyses revealed that age-related episodic autobiographical memory associations with anterior hippocampal volumes depended on sex. These findings suggest that age differences in brain structures implicated in episodic and semantic memory may portend reorganization of neural circuits to support autobiographical memory in later life.

Compromised future thinking: another cognitive cost of temporal lobe epilepsy.

The ability to mentally travel forward through time allows humans to envisage a diverse array of possible events taking place in the future, helping us to choose which pathway to take in life. In epilepsy, we assume that patients use this cognitive ability when deciding between various treatment options, but this assumption has not been robustly tested. The temporal lobes are key contributors to this ‘future thinking’ and its building blocks include cognitive functions commonly impaired in temporal lobe epilepsy such as memory and language, giving rise to a hypothesis that ‘future thinking’ is impaired in this patient cohort. Participants were 68 adults: 37 with neurosurgically-naïve, unilateral temporal lobe epilepsy (51% right lateralized) and 31 healthy controls of similar age, sex and intellectual ability to the participants with epilepsy. Future thinking was measured using an imagined experiences task validated in other neurological populations. Tools well-established in temporal lobe epilepsy were used to measure potential cognitive correlates of future thinking. Analysis of variance revealed significantly impoverished future thinking in both left and right temporal lobe epilepsy relative to controls (P = 0.001, ηp2=0.206), with no difference between temporal lobe epilepsy groups (P > 0.05). Future thinking deficits in left temporal lobe epilepsy were paralleled by deficits in scene construction, whereas impoverished future thinking in right temporal lobe epilepsy occurred in the setting of intact scene construction. Deficits in future thinking were associated with reductions in lexical access and episodic autobiographic memory in both epilepsy groups. In sum, future thinking is compromised in both left and right temporal lobe epilepsy. The deficit in left temporal lobe epilepsy is largely explainable by dysfunction in verbal cognitive processes including scene construction. While the basis of the deficits observed with right temporal foci shares features with that of left temporal lobe epilepsy, their intact scene construction raises questions about the role of the left and right temporal lobes in future thinking and scene construction and the relationship between these two constructs, including whether right temporal lobe might play a specific role in future thinking in terms of creative processing. Clinicians should take impaired future thinking into account when counselling temporal lobe epilepsy patients about various treatment options, as they may struggle to vividly imagine what different outcomes might mean for their future selves.

Neuropsychological Performance in Autoimmune Limbic Encephalitis: Evidence from an Immunotherapy-Naïve Cohort.

ObjectiveAutoimmune limbic encephalitis (ALE) is characterized by memory impairment, psychiatric symptoms, and epileptic seizures. Though, the neuropsychological profile of ALE is not yet well defined. However, there is some evidence that neuropsychological impairments might exceed those related to the limbic system and that different autoantibodies (AABs) are associated with distinguishable pattern of neuropsychological impairments. We provide a comprehensive presentation of neuropsychological performance of ALE in an immune therapy-naïve sample.MethodsWe retrospectively analyzed 69 immunotherapy-naïve ALE-patients (26 seropositive—[8 LGI1-, 4 CASPR2-, 2 GABAB-R-, 3 Hu-, 4 GAD65-, 2 Ma2-, 2 unknown antigen, and 1 Yo-AABs] and 43 seronegative patients, mean age 56.0 years [21.9–78.2], mean disease duration 88 weeks [0–572]). Neuropsychological evaluations comprised of the domains memory, attention, praxis, executive functions, language, social cognition, and psychological symptoms. We compared these functions between seronegative −, seropositive patients with AABs against intracellular neural antigens and seropositive patients with AABs against surface membrane neural antigens.ResultsNo effect of AAB group on neuropsychological performance could be detected. Overall, ALE predominantly presents with deficits in long-term memory and memory recognition, autobiographical-episodic memory loss, impairment of emotion recognition, and depressed mood. Furthermore, deficits in praxis of pantomimes and imitations, visuo-construction, and flexibility may occur.ConclusionALE shows a wide spectrum of neuropsychological impairments, which might exceed the limbic system, with no evidence of differences between AAB groups. Neuropsychological assessment for diagnosing ALE should include long-term memory, memory recognition, autobiographical-episodic memory, emotion recognition, and a detailed investigation of depression.