The Maricunga metallogenic belt, herein defined to encompass the region from 25° S to 28° S along the Cordillera Frontal of northern Chile, is known for hosting a series of gold-copper and lesser copper-molybdenum porphyries and gold-silver epithermal systems that are hosted in a segment of the late Oligocene-Miocene Andean calc-alkaline magmatic arc. Based on an up-to-date geochronological database, four episodes of magmatism and related hydrothermal deposits are proposed to characterize intensity and style of volcanism and hypabyssal intrusive rocks over time. The late Oligocene episode (26-21 Ma) is characterized by stratovolcanoes, dome complexes, pyroclastic sequences, and hypabyssal intrusives of andesitic to dacitic composition that host gold-rich porphyry systems such as Caspiche, Maricunga, and La Pepa. The early Miocene episode (21–17 Ma) has similar rock types but is volumetrically reduced, hosting epithermal and porphyry deposits like La Coipa and Caserones, respectively. A reinvigoration of volcanism occurred during the third stage between 17 and 11 Ma, giving rise to large volcanic complexes and intra-to extra-caldera ignimbritic deposits that host several gold-rich porphyry deposits such as Lobo-Marte, Luciano, and Cerro Casale; as well as epithermal deposits such as Fenix. Some of the 17 to 11 Ma and younger igneous rock belong to the high-K calc-alkaline series, showing a higher alkali content compared to previous periods. The last magmatic episode, from 11 to 5 Ma, coincides with the shallowing of the subduction angle and is characterized by an eastward migration of volcanism, and more heterogeneous rocks including trachytic compositions. During this period mineralization was emplaced at the Salares Norte epithermal deposit and El Volcan porphyry Au–Cu deposit.Porphyry and epithermal systems formed throughout the evolution of the Maricunga belt. Overprint of advanced argillic alteration on porphyry style alteration is widespread albeit commonly devoid of significant addition of epithermal Au–Ag mineralization. The Au-rich nature of the majority of the porphyry systems is attributed to the shallow crustal depths of emplacement compared to Cu- and Mo-rich porphyry systems. Conversely, high-sulfidation epithermal Au–Ag deposits such as La Coipa and Nueva Esperanza are not known to be telescoped on coeval porphyry gold deposits.The location of the mineralized centers was favored by crustal weaknesses expressed by intersection of oblique- and parallel-to arc structures, the former inherited from the construction of the continent before to the formation of the Andean range. The arc oblique structures also segment the Maricunga belt into domains with unique magmatic and hydrothermal styles.