Background: Prior studies have shown that acute cardiovascular disease (CVD) may be triggered by external stressors; however, it remains uncertain how to use this information for disease prevention. Aim: To determine, using a randomised controlled study design, whether it is feasible for individuals with ≥2 risk factors or known CVD, to take targeted medication using customised packaging for specific stressors. Assessments include haemodynamics, lipids and inflammatory markers, and questionnaires of self-mastery and quality of life. Methods: Subjects initially recorded episodes of heavy physical exertion, anger and anxiety, heavy meals and respiratory infection over 2 weeks. After baseline measures and questionnaires were obtained, subjects were randomised to control (usual therapy) or a treatment strategy for 4 months, during which they were additionally instructed to take either aspirin 100 mg and propranolol 10 mg (for episodes of significant physical and emotional stress), or aspirin alone (for respiratory infection and heavy meal). Results: In this ongoing study, 20 subjects have completed the protocol. Using Likert scales, subjects randomised to treatment reported that the medication packaging was convenient, and they were confident in taking the medication and sustaining the strategy into the future. Feedback included a greater insight into their health and improved dealing with anxiety and anger. Ongoing subject enrolment will enable evaluation of other study endpoints. Conclusions: Initial data suggest that it is feasible to conduct a randomised-controlled trial for individuals at increased CVD risk to identify potential triggers of acute CVD and take targeted medication at the time of these triggers.