To evaluate the feasibility of endoscopic gastrojejunal tube (GJT) placement in infants and children. All children undergoing endoscopic GJT placement between January 2010 and December 2019 were included in this single-center retrospective study. Difficulties with and failure of GJT placement, complication rates, and device longevity, efficacy, and duration were assessed. A total of 107 children, median age 10months (IQR, 5.0-23.0months) and median weight 6.6kg (IQR, 5.3-9.5kg), underwent endoscopic GJT placement using the gastric stoma to introduce the endoscope (one step: n=36 of 107; 33.6%). Endoscopic placement was successful in 99%. Eight periprocedure complications occurred, including 1 pneumoperitoneum requiring exsufflation, 2 acute pulmonary hypertension episodes leading to death in 1 case, and 5 episodes of bronchospasm. Minor complications were frequent and mostly mechanical (79%), whereas major complications were rare (5.6%): intussusception (n=4), intestinal perforation (n=1), and pneumoperitoneum (n=1). Ten patients died. Of the 97 patients who lived, 85 (87%) were weaned from jejunal feeding at a median of 179days (IQR, 69-295days) after initiation. Among them, 30 (35.2%) required fundoplication. Weight for age z-score was significantly higher at weaning. GJT placement is feasible in children, even low-weight infants. Complications are frequent but are mostly minor.