Epidemiology Of Acute Pancreatitis Research Articles

The epidemiology of acute pancreatitis in tasmania over a 12-year period: Is this a disease of disadvantage?

BackgroundThe global incidence of acute pancreatitis (AP) is increasing, but little information exists about trends in Australia. This study aimed to describe incidence trends, along with clinical and socio-demographic associations, in the state of Tasmania over a recent 12-year period. MethodsThe study cohort was obtained by linking clinical and administrative datasets encompassing the whole Tasmanian population between 2007 and 2018, inclusive. Pancreatitis case definition was based on relevant ICD-10 hospitalization codes, or elevated serum lipase or amylase in pathology data.Age-standardised incidence rates were estimated, overall and stratified by sex, aetiology, and Index of Relative Socio-economic Disadvantage (IRSD). ResultsIn the study period, 4905 public hospital AP episodes were identified in 3503 people. The age-standardised person-based incidence rate across the entire period was 54 per 100,000 per year. Incidence was inversely related to IRSD score; 71 per 100,000 per year in the most disadvantaged quartile compared to 32 in the least disadvantaged. Biliary AP incidence was higher than that of alcohol-related AP, although the greatest incidence was in “unspecified” cases. There was an increase in incidence for the whole cohort (average annual percent change 3.23 %), largely driven by the two most disadvantaged IRSD quartiles; the least disadvantaged quartile saw a slight overall decrease. ConclusionThis is the first Australian study providing robust evidence that AP incidence is increasing and is at the upper limit of population-based studies worldwide. This increased incidence is greatest in socio-economically disadvantaged areas, meriting further research to develop targeted, holistic management strategies.

The epidemiology of acute pancreatitis in a tertiary care hospital in Dubai.

The prevalence of acute pancreatitis is rising especially in the Western world, but the prevalence remains unknown in most Middle Eastern Countries. Acute pancreatitis has been attributed with multiple etiologies with the two most common being alcohol abuse disorder and gallstones. The incidence and prevalence of it in the United Arab Emirates are yet to be reported. The Atlanta criteria were used for the diagnosis of acute pancreatitis and applied to patients that have been admitted to a single tertiary center in the year 2021. Several variables were investigated including gender, age, clinical presentation, etiology, radiological and laboratory results, complications, and outcome. Moreover, the Bedside Index for Severity in Acute Pancreatitis score was used to assess and determine the severity of acute pancreatitis in these patients. Nineteen patients were identified in our database with 52% being males. The mean age of patients was 41 years. The most frequent presentation was abdominal pain in 100% of our patients. Moreover, the most common etiology identified was idiopathic (52.63%), followed by biliary (21.05%). The mortality rate was 0%. This is the first retrospective study in Dubai on acute pancreatitis. Pancreatitis is a life-threatening condition with multiple etiologies. Physicians should consider multifactorial acute pancreatitis in patients with different comorbidities.

Epidemiology of acute pancreatitis in Australia from 2007-2019.

There is a paucity of information on the epidemiology of acute pancreatitis (AP) in Australia. Data on hospital admissions for a principal diagnosis of AP were obtained from the Australian Institute of Health and Welfare; population data were extracted from the Australian Bureau of Statistics. Age-adjusted, and age and sex-specific rates for all subtypes of AP were compared. There were 208 390 admissions for a principal diagnosis of AP in Australia between 2006/07 and 2018/19, corresponding to an average admission rate of 46.03/105 /year. Over the study, there was a 38.7% increase in the age-adjusted rate of AP admissions [37.56 to 52.09/105 /year (P< 0.00001)], corresponding to an average increase of 3.0%/year. Unspecified AP comprised approximately 50% of admissions in each year. An increase in admission rates was observed for all categories of AP. Biliary AP admission rates increased from 8.28 to 13.90 /105 /year (P< 0.00001), increasing in both sexes and all age groups. Alcohol associated AP admissions increased from 8.23 to 9.98/105 /year (P< 0.00001), a phenomenon which was seen in older people and in females particularly, but there was a reduction alcohol related AP admission rates in the 20-29-year age group. AP admission rates increased significantly over the period 2006/07 to 2018/19 in both male and female populations, in most subtypes of AP, particularly 'unspecified AP', and among all age groups.

Sa1382 – The Epidemiology of Acute Pancreatitis in Crohn's Disease: A Population-Based Study from 2013-2018

Sa1382 – The Epidemiology of Acute Pancreatitis in Crohn's Disease: A Population-Based Study from 2013-2018

Tu1418 – The Epidemiology of Acute Pancreatitis in Ulcerative Colitis: A Population-Based Study from 2013-2018

Tu1418 – The Epidemiology of Acute Pancreatitis in Ulcerative Colitis: A Population-Based Study from 2013-2018

Mo1025 - Epidemiology of Acute Pancreatitis in Celiac Disease in the United States Between 2012 and 2017: A Population-Based National Study

Mo1025 - Epidemiology of Acute Pancreatitis in Celiac Disease in the United States Between 2012 and 2017: A Population-Based National Study

Men With Acute Pancreatitis Admitted to U.S. Hospitals Have Increased Comorbidities and Higher In-hospital Mortality

Introduction: Influence of gender in the epidemiology of acute pancreatitis (AP) has been previously reported. We aim to analyze gender based differences of AP hospitalizations in the US over the past decade. We hypothesize that men with AP are likely to develop severe complications and have a higher in-hospital mortality rate. Methods: Between 2005 to 2012, data was extracted from the National Inpatient Sample on adult (Age>18 years) patients with AP (ICD 9 CM: 577.0). Exclusion criteria was applied for chronic pancreatitis and other pancreatic and biliary disorders (ICD 9 CM: 577.1, 577.8, 577.9, 157.0, 157.1, 157.2, 157.3, 157.4, 157.8, 157.9, 155.0, 155.1, 155.2,156.0, 156.1, 156.2, 156.8. 156.9). Using multivariate logistic regression, in-hospital mortality, comorbidities, complications and procedure rates were compared between the men and women with AP (SAS version 9.3). Results: During the study period, 293,165 women and 286,573 men with acute pancreatitis were admitted to the US hospitals, with a ratio of 1.03:1. Men admitted for AP had increased number of comorbidities: DM (P<0.0001), Hypertension (P<0.0001), Hyperlipidemia (P<0.0001) and CAD (P<0.0001). Men were more likely to be smokers (23.9% vs.15.6%, P<0.0001) and had history of drug abuse (33.6% vs.19.6%, P<0.0001) and alcohol abuse (19.7% vs. 7.2%, P<0.0001). Women were more likely to have biliary tract disorders (39.3% vs 26.8%, P<0.0001). Men were more likely to be evaluated by CT (2.9% vs 2.7%, P<0.0001) while women were more likely to undergo Ultrasound (1.6% vs. 1.5%, P=0.02) and MRCP (1.2% vs. 0.9%, P<0.0001). Men were more likely to develop septic shock (2.2% vs 1.8%, P<0.0001), ARDS (5.2% vs. 3.9%, P<0.0001) and required more intubation (4.3% vs. 3.0%, P<0.0001). Women were more likely to undergo biliary intervention (cholecystectomy, biliary stenting, ampullary surgery). More men received enteral nutrition (1.2% vs. 0.9%, P<0.0001) while more women received TPN (2.6% vs. 2.4%, P<0.0001). Men with AP had a higher in-hospital mortality rate (2.8% vs. 2.4%, P<0.0001). Conclusion: Men are more likely to be hospitalised with alcoholic pancreatitis and women are more likely to be hospitalized with biliary pancreatitis. Men with AP are likely to develop severe complications leading to higher in-hospital mortality when compared with women. Men with AP may benefit from more intensive treatment at the onset for better outcome.

A Study on the Etiology, Severity, and Mortality of 3260 Patients With Acute Pancreatitis According to the Revised Atlanta Classification in Jiangxi, China Over an 8-Year Period

Currently, the epidemiology of acute pancreatitis (AP) according to the Atlanta classification 2012 is rare. Thus, we aim to evaluate the etiology, severity, and mortality of AP according to Atlanta classification 2012 in Jiangxi, China. We analyzed 3260 hospitalized patients between 2005 and 2012 from AP database. The severity was classified by the Atlanta classification 2012. 3260 patients were admitted. Cholelithiasis (58.7%), hyperlipidemia (14.3%), and alcohol (4.5%) were the top 3 etiologies. Besides, in 16.7% of patients, the etiology still unexplained. 1238 patients (38.0%) were categorized as mild, 1551 (47.6%) as moderate, and 471 (14.4%) as severe acute pancreatitis. Hyperlipidemia and alcohol were the more common cause in men, especially the younger and middle aged, whereas cholelithiasis were the more common cause in women, especially the elderly. The overall mortality of AP was 1.2% and 8.5% in severe acute pancreatitis. Meanwhile, both severe idiopathic and hyperlipidemic pancreatitis had significantly higher mortality rate than severe biliary pancreatitis. Cholelithiasis was the main etiology in Jiangxi, China, and hyperlipidemia ranked second. There were different etiological proportion according to age, sex, and severity. Furthermore, the higher mortality rate occurred in severe idiopathic and hyperlipidemic pancreatitis, although there was no clear association between mortality and age.

Comparison Between Revised Atlanta Classification and Determinant-Based Classification for Acute Pancreatitis in Intensive Care Medicine. Why Do Not Use a Modified Determinant-Based Classification?

To compare the classification performance of the Revised Atlanta Classification, the Determinant-Based Classification, and a new modified Determinant-Based Classification according to observed mortality and morbidity. A prospective multicenter observational study conducted in 1-year period. Forty-six international ICUs (Epidemiology of Acute Pancreatitis in Intensive Care Medicine study). Admitted to an ICU with acute pancreatitis and at least one organ failure. Modified Determinant-Based Classification included four categories: In group 1, patients with transient organ failure and without local complications; in group 2, patients with transient organ failure and local complications; in group 3, patients with persistent organ failure and without local complications; and in group 4, patients with persistent organ failure and local complications. A total of 374 patients were included (mortality rate of 28.9%). When modified Determinant-Based Classification was applied, patients in group 1 presented low mortality (2.26%) and morbidity (5.38%), patients in group 2 presented low mortality (6.67%) and high morbidity (60.71%), patients in group 3 presented high mortality (41.46%) and low morbidity (8.33%), and patients in group 4 presented high mortality (59.09%) and morbidity (88.89%). The area under the receiver operator characteristics curve of modified Determinant-Based Classification for mortality was 0.81 (95% CI, 0.77-0.85), with significant differences in comparison to Revised Atlanta Classification (0.77; 95% CI, 0.73-0.81; p < 0.01), and Determinant-Based Classification (0.77; 95% CI, 0.72-0.81; p < 0.01). For morbidity, the area under the curve of modified Determinant-Based Classification was 0.80 (95% CI, 0.73-0.86), with significant differences in comparison to Revised Atlanta Classification (0.63, 95% CI, 0.57-0.70; p < 0.01), but not in comparison to Determinant-Based Classification (0.81, 95% CI, 0.74-0.88; nonsignificant). Modified Determinant-Based Classification identified four groups with different clinical presentation in patients with acute pancreatitis in ICU, with better discriminatory power in comparison to Determinant-Based Classification and Revised Atlanta Classification.

Epidemiology of acute pancreatitis on etiology: a study of 3,260 patients according to the revised Atlanta classification in Jiangxi during 8 years

Epidemiology of acute pancreatitis on etiology: a study of 3,260 patients according to the revised Atlanta classification in Jiangxi during 8 years

Epidemiologia ostrego zapalenia trzustki w Polsce – wybrane problemy

Epidemiologia ostrego zapalenia trzustki w Polsce – wybrane problemy

Epidemiology of acute pancreatitis in hospitalized children in the United States from 2000-2009.

BackgroundSingle-center studies suggest an increasing incidence of acute pancreatitis (AP) in children. Our specific aims were to (i) estimate the recent secular trends, (ii) assess the disease burden, and (iii) define the demographics and comorbid conditions of AP in hospitalized children within the United States.MethodsWe used the Healthcare Cost and Utilization Project Kids’ Inpatient Database, Agency for Healthcare Research and Quality for the years 2000 to 2009. Extracted data were weighted to generate national-level estimates. We used the Cochrane-Armitage test to analyze trends; cohort-matching to evaluate the association of AP and in-hospital mortality, length of stay, and charges; and multivariable logistic regression to test the association of AP and demographics and comorbid conditions.ResultsWe identified 55,012 cases of AP in hospitalized children (1–20 years of age). The incidence of AP increased from 23.1 to 34.9 (cases per 10,000 hospitalizations per year; P<0.001) and for all-diagnoses 38.7 to 61.1 (P<0.001). There was an increasing trend in the incidence of both primary and all-diagnoses of AP (P<0.001). In-hospital mortality decreased (13.1 to 7.6 per 1,000 cases, P<0.001), median length of stay decreased (5 to 4 days, P<0.001), and median charges increased ($14,956 to $22,663, P<0.001). Children with AP compared to those without the disease had lower in-hospital mortality (adjusted odds ratio, aOR 0.86, 95% CI, 0.78–0.95), longer lengths of stay (aOR 2.42, 95% CI, 2.40–2.46), and higher charges (aOR 1.62, 95% CI, 1.59–1.65). AP was more likely to occur in children older than 5 years of age (aORs 2.81 to 5.25 for each 5-year age interval). Hepatobiliary disease was the comorbid condition with the greatest association with AP.ConclusionsThese results demonstrate a rising incidence of AP in hospitalized children. Despite improvements in mortality and length of stay, hospitalized children with AP have significant morbidity.

The Epidemiology of Acute Pancreatitis within a Nationwide Military Population

The Epidemiology of Acute Pancreatitis within a Nationwide Military Population

Sa1378 The Epidemiology of Acute Pancreatitis Within a Nationwide Military Population

Sa1378 The Epidemiology of Acute Pancreatitis Within a Nationwide Military Population

Epidemiology of Acute Pancreatitis in the North Adriatic Region of Croatia during the Last Ten Years

Introduction. Several European studies have reported an increase in the incidence rate of acute pancreatitis (AP). Therefore, we studied the incidence rate of AP in the North Adriatic Region in Croatia, as well as epidemiological analysis concerning etiology, age, gender, and severity of disease. Methods. We analyzed 922 patients with confirmed diagnosis of AP (history, clinical and laboratory findings, and imaging methods) admitted to our hospital during a ten-year period (2000–2009). Epidemiological analysis was carried out focusing on incidence, demographic data, and etiology, as well as severity of the disease based on the Ranson and APACHE II scores. Results. The incidence rate varied from 24 to 35/100 000 inhabitants annually. Mean age was 60 ± 16 years. There were 53% men and 47% women among the patients. Most frequent etiologies of AP were biliary stones in 60% and alcohol abuse in 19% of patients. According to the Ranson and APACHE II scores, pancreatitis was considered to be severe in 50% and 43% of the cases, respectively. Conclusion. In our region the incidence of AP was around 30 per 100,000 population per year during the ten-year period studied. The mean age at admission was 60 years and etiology was predominantly biliary. In our region, we have shown epidemiological characteristics of AP typical for Mediterranean countries.

New Insights into Pathogenesis, Diagnosis, and Treatment of Pancreatic Disorders

New Insights into Pathogenesis, Diagnosis, and Treatment of Pancreatic Disorders

Acute and recurrent pancreatitis in children: exploring etiological factors

Objective. Etiologies of acute pancreatitis (AP) in children are more variable than in adults, including drugs, traumas, infections and multisystem disorders as well as biliary anomalies. While causes of pancreatitis have been extensively analyzed, different series reported different causes. The aims of this study were: 1) to assess the etiological factors of acute and recurrent pancreatitis in a pediatric population from a tertiary care hospital; 2) to assess the usefulness of imaging studies in diagnosing etiologies of pancreatitis. Material and methods. Thirty-four children (median age 11 years, 23 males) with AP and 11 with recurrent pancreatitis were retrospectively studied to assess etiology of pancreatitis in children. Results. The most common etiologies of AP were medications (11/34) and biliary tract diseases (9/34), whereas systemic diseases accounted for a small percentage of case. Among patients with recurrent episodes, biliary anomalies were the most common cause (6/11), whereas only 2 out of 11 patients with recurrent pancreatitis presented a hereditary cause. Conclusions.This study highlights that etiologies of AP in children are variable. Epidemiology of AP could be influenced by single center's characteristics. Anatomic anomalies should be ruled out and genetic causes should be considered in recurrent cases.

Fatal Outcome in Acute Pancreatitis: Its Occurrence and Early Prediction

Background/Aims: This study aims to determine predictability of death in acute pancreatitis at a secondary-care hospital in Germany. Methods: This study is part of an ongoing study on the epidemiology of acute pancreatitis and covers 368 patients with a first attack of acute pancreatitis in Lüneburg county from 1988 to 1999. Early and late mortality were defined as ≤1 weeks and >1 week after admission. The following parameters were used to establish on admission likelihood of death: admission within 24 h or later with an acute attack, abdominal tenderness, signs of peritonitis, amylase and lipase in serum, leukocytes, hematocrit, potassium, sodium, calcium, creatinine after rehydration, blood glucose, bilirubin, serum glutamate-oxalacetate transaminase (SGOT), serum lactate dehydrogenase (SLDH), arterial pO₂, APACHE II score, Ranson and Imrie scores. Results: Of the 368 patients 17 (5%) died, 7 early because of multiple organ failure and 10 late because of septic complications. Mortality rates in interstitial and necrotising pancreatitis were 3 and 17%, respectively. Only an elevated serum creatinine (>2.0 mg/dl) and a blood glucose >250 mg significantly correlated with mortality. Ranson and Imrie scores were also significantly correlated with mortality; however, they were not obtained on admission, but only after 48 h. In univariate analysis, APACHE II score ≧6 on admission and lipase >1,000 U/l on admission provided a high sensitivity and negative predictive value for early and late mortality patients. Conclusion: Approximately half of the deaths in acute pancreatitis occur because of multiple organ failure or septic complications. New approaches have to be found to counteract these severe complications. A fatal outcome may be predicted by simple laboratory parameters such as a high serum creatinine and blood glucose. An APACHE II score ≧6 and a lipase level on admission ≧1,000 U/l indicate severe pancreatitis.

Acute pancreatitis: does gender matter?

In a number of gastrointestinal and nongastrointestinal diseases, gender has been proven to be an independent risk factor for severity. To determine whether this holds true for severity in acute pancreatitis is the aim of our study. This paper derives from a prospective study on the epidemiology of acute pancreatitis, which included 274 patients (172 male and 102 female) with a first attack of the disease. Severity parameters were: Atlanta criteria (arterial Po2 < or = 60 mm Hg, and serum creatinine on admission >2 mg/dl after rehydration); Ranson's and Imrie's prognostic factors; APACHE II score; Balthazar-scored contrast-enhanced computed tomography (CT) results obtained within 72 hr of admission; days spent in the intensive care unit and total hospital stay; the necessity for artificial ventilation, dialysis, or surgery; and mortality. As already known, there is a significant association between gender and etiology of pancreatitis in general. Not surprisingly, the men in our study had alcohol-induced acute pancreatitis more frequently than women, whereas biliary pancreatitis predominated among the women. As for severity, there was no significant association between gender and any of the severity parameters with a few minor exceptions: longer hospital stays, higher Imrie scores and more pseudocysts for women, and more necroses in women with idiopathic pancreatitis. Thus, gender is no independent risk factor for the severity and outcome of acute pancreatitis.