New Insights into Pathogenesis, Diagnosis, and Treatment of Pancreatic Disorders

Grazyna Rydzewska,Jean Morisset,Davor Stimac

doi:10.1155/2013/305179

Grazyna Rydzewska, Jean Morisset + Show 1 more

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https://doi.org/10.1155/2013/305179

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Abstract

New Insights into Pathogenesis, Diagnosis, and Treatment of Pancreatic Disorders

Highlights

Prediction of severity of acute pancreatitis (AP) by a simple unique laboratory test would be very helpful as it could direct management from the very beginning and at the end improve the outcome
In spite of signi cant improvement in understanding the basic pathophysiology of the disease and advances in the diagnosis and management of acute pancreatitis, the mortality rate has remained stable since the 1970s
Authors discussed prognostic value of interleukins (IL) 6, 8, and 10, soluble receptor for tumor necrosis factor, pancreatic elastase (E1), and Creactive protein (CRP) as predictors of systemic complications in patients with Acute pancreatitis (AP). ey found that IL-6, IL-8, IL-10, and sTNFr measured on admission and CRP and pancreatic elastase measured on the third day of admission represent valuable prognostic factors in the determination of severity and systemic complications in patients with AP

Summary

Introduction

Prediction of severity of acute pancreatitis (AP) by a simple unique laboratory test would be very helpful as it could direct management from the very beginning and at the end improve the outcome. Pancreatic disorders, such as acute and chronic pancreatitis and pancreatic cancer, are until now challenging diseases to manage, with signi cant burdens of morbidity, mortality rate, and high nancial costs. In spite of signi cant improvement in understanding the basic pathophysiology of the disease and advances in the diagnosis and management of acute pancreatitis, the mortality rate has remained stable since the 1970s.

Results

Conclusion