To capture the impact of spatial heterogeneity of environment and movement of individuals on the persistence and extinction of a disease, Allen et al. in [L.J.S. Allen, B.M. Bolker, Y. Lou, A.L. Nevai, Asymptotic profiles of the steady states for an SIS epidemic reaction–diffusion model, Discrete Contin. Dyn. Syst. Ser. A 21 (1) (2008) 1–20] proposed a spatial SIS (susceptible-infected-susceptible) reaction–diffusion model, and studied the existence, uniqueness and particularly the asymptotic behavior of the endemic equilibrium as the diffusion rate of the susceptible individuals goes to zero in the case where a so-called low-risk subhabitat is created. In this work, we shall provide further understanding of the impacts of large and small diffusion rates of the susceptible and infected population on the persistence and extinction of the disease, which leads us to determine the asymptotic behaviors of the endemic equilibrium when the diffusion rate of either the susceptible or infected population approaches to infinity or zero in the remaining cases. Consequently, our results reveal that, in order to eliminate the infected population at least in low-risk area, it is necessary that one will have to create a low-risk subhabitat and reduce at least one of the diffusion rates to zero. In this case, our results also show that different strategies of controlling the diffusion rates of individuals may lead to very different spatial distributions of the population; moreover, once the spatial environment is modified to include a low-risk subhabitat, the optimal strategy of eradicating the epidemic disease is to restrict the diffusion rate of the susceptible individuals rather than that of the infected ones.