Introduction: Eosinophilic gastrointestinal disorders (EGIDs) are inflammatory disorders characterized by eosinophilic infiltration of different segments of the gastrointestinal (GI) tract without a known cause. While Eosinophilic esophagitis (EoE) has been extensively studied, there is limited data on the epidemiology of other EGIDs. We sought to describe the epidemiology of eosinophilic gastritis (EoG), gastroenteritis (EoGE), and colitis (EoC) in the United States, utilizing a large population-based database. Methods: We queried a commercial database (Explorys Inc, Cleveland, OH), an aggregate of electronic health record data from 26 major integrated US healthcare systems from 1999 to June 2016. We identified an aggregated patient cohort of eligible patients with EoG, EoGE and EoC between June 2011 to June 2016, based on Systematized Nomenclature Of Medicine - Clinical Terms (SNOMED-CT). We calculated the prevalence of EoG, EoGE and EoC among different patient groups. Results: Of the 30,557,300 individuals in the database active between June 2011 to June 2016, we identified 470, 830 and 510 patients with EoG, EoGE and EoC respectively. The overall 5-year prevalences of EoG, EoGE and EoC were 1.5/100,000, 2.7/100,000 and 1.7/100,000 respectively (Figure 1). While EoGE had a peak prevalence in younger age-groups, EoG and EoC demonstrated a more uniform distribution across age-groups (Figure 2). Prevalence of EoGE was higher in children (< 18yrs) vs adults (>18yrs) (OR 1.24; 95% CI: 1.05-1.48, p=0.013) and Caucasians vs. African-Americans and Asians (OR 1.24; 95% CI: 1.01-1.51, p=0.04). Prevalence of EoC was higher in females vs. males (OR 1.25; 95% CI: 1.05-1.49, p=0.014). Compared with controls (individuals in database without EGIDs), individuals with EoG, EoGE and EoC were more likely to have other gastrointestinal diagnoses such as dysphagia and at least one allergic condition (Table 1).Figure 1Figure 2Table 1: Clinical features of Eosinophilic gastroenteritis (EoGE), gastritis (EoG) and colitis (EoC)Conclusion: In this large population-based study, we found that the estimated 2011-2016 prevalences EoG, EoGE and EoC were 1.5/100,000, 2.7/100,000 and 1.7/100,000 respectively, which are at the lower end of prevalence rates reported in US and other industrial countries. We confirmed that EoG, EoGE and EoC have a strong association with allergic and gastrointestinal diagnoses. Further studies are needed to understand the evolving epidemiology of these disorders.