This study was conducted to determined the effect of dietary sodium bicarbonate as a replacement of sodium chloride salt on some blood and physiological parameters of broilers experimentally infected with Eimeria. A totally of 120 one-day old chicks were divided into three groups, 40 chicks in each . The first group fed standard ration supplemented with 0.3 % sodium chloride salt, second and third groups were fed standard ration supplemented with 0.3 and 0.6 % sodium bicarbonate salt respectively. Blood samples were collected from all groups after experimentally infected with Eimeria. The results revealed that dietary sodium bicarbonate as a replacement of sodium chloride salt did not affected blood and physiological parameters of broilers before Eimeria infection, when as replacement of sodium bicarbonate salt (T2 and T3) groups significantly (P<0.05) increased blood Hb, RBC, Lymphocyte cell and serum enzymes activity in comparison with control (T1) . This indicated the important of dietary sodium bicarbonate as a replacement of sodium chloride salt to improve health and physiological status of broilers experimentally infected with Eimeria.