Design of experiment (DOE) is the focal collective of quality technique and is widely used in Research and Development (R&D) organization to optimize product design parameters. There are three main DOE approaches that commonly adopted by R&D companies, which are the classical Fisher’s DOE, Taguchi DOE and Shainin DOE. This paper explores how these three main DOE approaches could be integrated to optimize product design parameters in a Research and Development company. The paper starts with enlightenment of the common DOE steps, follows by discussion of issues faced by the Research and Development company during the implementation of the three DOE approaches in product design. The paper subsequently illustrates how the three DOE approaches could be integrated as a new methodology for optimization of product design parameters. The integrated DOE methodology presented in this paper offers an alternative and effective way to conduct DOE in a dynamic product design and development environment.