BackgroundOne of the major environmental problems of the modern world is noise. A health-related marker of environmental noise exposure that can be considered a predictor of annoyance is noise sensitivity. The aim of this study was to ascertain the correlation between levels of exposure to road traffic noise in residential areas and the resulting annoyance based on the perception and sensitivity reported. MethodsThe study involved noise assessment, with the creation of noise maps of the neighborhood in the city of São Paulo, Brazil, and application of a questionnaire to ascertain the perception of the residents of the neighborhood, regarding the effects of this exposure. ResultsThe noise levels at all the measured points were found to exceed the critical level for the area, 55 dB(A). A total of 225 interviews were conducted. Noise-related annoyance was reported by 48.4% of the respondents. Associations were observed between living in areas exposed to traffic noise and feeling annoyed with this noise (p < 0.001). ConclusionsThese findings suggest the importance of reviewing and updating Brazilian public policies regarding environmental noise. We found a high prevalence of annoyance reports, as well as aspects indicative of sensitivity to noise exposure.