Environmental Modifications Research Articles

Resilience and high compositional variability reflect the complex response of river waters to global drivers: The Eastern Siberian River Chemistry database

The chemical composition of river waters represents an important matter of investigation to understand environment modifications in response to climate changes and global warming. Prolonged dry periods, heavy flood events, degradation of the lands and ice thawing, modify the chemical composition of river waters influencing the drivers governing the complex dynamics of river catchments where everything comes together. In this framework, Compositional Data Analysis (CoDA) offers methods in which the complex structure of the river water composition and the interrelationships among the various components are put into the proper context for their statistical analysis. In this research, we propose a new CoDA approach combining the robust Mahalanobis distance (D) calculus of ilr-transformed chemical variables and the perturbation difference, both with respect to a pristine compositional benchmark. The aim was to trace the change in the chemical composition of the Eastern Siberian River Chemistry Database where degradation of the permafrost for global warming produces important effects on natural waters. The findings indicate complex multiplicative laws and feedback mechanisms governing solutes in Eastern Siberian rivers, with high values of D found where permafrost is more discontinuous. Perturbations clearly discriminate chemical components more resilient to stresses induced by global changes (Ca2+, Mg2+ and HCO3−) from those whose variability is not maintained under control (Cl−, Na+, SO42−). These outcomes open up a new scenario in searching for spatiotemporal resilience metrics to reveal rivers response to environmental changes.

Telehealth interventions in occupational therapy with older adults: Results from a scoping review targeting better health promotion.

Telehealth interventions have the potential to enhance access to care and improve efficiency while reducing the burden on patients. Although telehealth interventions are well accepted and adopted in physical therapy, their usage in occupational therapy for older adults is less common, and limited information exists regarding their setting and context. To provide an inventory and synthesis of telehealth interventions in occupational therapy for older adults. For published studies on telehealth-based occupational therapy interventions in older adults between 2000 and 2022, six databases were reviewed. Data extraction and analysis were guided by the taxonomies developed by Tulu, McColl and Law and informed by the Canadian Model of Occupational Performance and Engagement. Twenty-three studies on telehealth interventions in occupational therapy for older adults were identified, mostly from North American authors (n = 11; 47.8%) and randomised clinical trials (n = 9; 39.1%). Most participants had a health problem (n = 20; 87.0%), mainly stroke (n = 9; 39.1%). Interventions focussed primarily on symptom management education (n = 12; 52.2%) of community-dwelling adults with health conditions, using videoconferencing systems or applications (n = 14; 60.7%). Interventions were delivered from the healthcare centre (n = 6; 26.1%) to the person's home (n = 18; 78.3%) synchronously (n = 19; 82.6%). About one third (n = 8; 34.8%) of the studies specified the therapist's location. Published studies on telehealth interventions in occupational therapy with older adults have mainly focussed on the synchronous training and education of participants using videoconferencing systems or applications. According to these studies, the scope of interventions is limited and could be expanded, for example, through occupational development and environmental modification. To better understand and describe best practices in the use of telehealth in occupational therapy, future studies should provide more details about the interventions performed, the technology used and the environmental settings of the therapist.

Reducing restraint on residents in Hong Kong care home settings

Reducing restraint on residents in Hong Kong care home settings Individuals from the Jockey Club Centre for Positive Ageing discuss reducing using restraint on residents in Hong Kong care home settings. Restraint use among residents in care home settings could be significantly reduced by implementing a multi-component restraint reduction programme, a research study conducted by Jockey Club Centre for Positive Ageing (JCCPA) said. (1) The study involved the implementation of a comprehensive programme over 12 months. The programme included staff training, examination of current care practices, environmental design modifications, monthly case conferences, and support from multidisciplinary experts. Implemented in two care homes, the programme demonstrated a significant 30% reduction in restraints. One of the primary reasons for employing restraints, fall prevention from chairs, was also significantly reduced following the implementation of the restraint reduction programme.

HMGB1 Signaling-Mediated Tumor Immunity in Cancer Progress.

Tumor immunity is a cycle that begins with the release of antigens from tumor cells and ends with the destruction of tumor cells. High mobility group box 1 (HMGB1) is a nonhistone protein widely present in the nucleus of mammalian cells and can be released by immune cells or tumor cells. As a proinflammatory mediator or alarm protein, the activity and function of HMGB1 are determined by the environment, binding receptors, redox status and posttranslational modifications (PTMs), and HMGB1 plays a key role in inflammation and tumor immune processes. In this review, we summarize in detail the current studies on the dual role of HMGB1 in tumor immunity, focusing mainly on immunosuppressive effects, such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), as well as antitumor immunoenhancement effects, such as immunogenic cell death (ICD). Finally, we discuss the potential and challenges of HMGB1 in antitumor immunotherapy.

Review of forms of corrosion and mitigation techniques: A visual guide

Over the years, issues relating to corrosion have been a serious challenge confronting effective scientific and engineering applications of metallic materials in the industry. Annual loss due to corrosion issues has been quite alarming as it runs into trillions of dollars. In this review, forms of corrosion, factors affecting each form, mechanism of formation, and different aggressive environments that propagate corrosion have been identified. Mitigation techniques against this threat were all discussed, especially those involving the use of eco-friendly, cheap, available, and non-toxic materials. It was observed that the principle, process, and conditions governing each form of corrosion must be well understood before it can be effectively mitigated. This can be done either by proper material selection and design, environmental measures, modification and engineering design, modification of corrosive media, use of inhibitors, or sacrificial and protective coatings. However, adequate knowledge of the environment and nature of metal to be deployed in such an environment is essential in ensuring such material's protection, safety, and durability. For efficient and effective corrosion prevention and control, these mitigation techniques can either be implored exclusively or collectively depending on the material's nature and the setting in which it will be used.

Threshold dynamics of an almost periodic vector-borne disease model.

Many infectious diseases cannot be transmitted from human to human directly, and the transmission needs to be done via a vector. It is well known that vectors' life cycles are highly dependent on their living environment. In order to investigate dynamics of vector-borne diseases under environment influence, we propose a vector-borne disease model with almost periodic coefficients. We derive the basic reproductive number [Formula: see text] for this model and establish a threshold type result on its global dynamics in terms of [Formula: see text]. As an illustrative example, we consider an almost periodic model of malaria transmission. Our numerical simulation results show that the basic reproductive number may be underestimated if almost periodic coefficients are replaced by their average values . Finally, we use our model to study the dengue fever transmission in Guangdong, China. The parameters are chosen to fit the reported data available for Guangdong. Numerical simulations indicate that the annual dengue fever case in Guangdong will increase steadily in the near future unless more effective control measures are implemented. Sensitivity analysis implies that the parameters with strong impact on the outcome are recovery rate, mosquito recruitment rate, mosquito mortality rate, baseline transmission rates between mosquito and human. This suggests that the effective control strategies may include intensive treatment, mosquito control, decreasing human contact number with mosquitoes (e.g., using bed nets and preventing mosquito bites), and environmental modification.

A Review on Global Cooperation Network in the Interdisciplinary Research of Geochemistry Combined with Artificial Intelligence

With the rapid development of modern geochemical analysis techniques, massive volumes of data are being generated from various sources and forms, and geochemical data acquisition and analysis have become important tools for studying geochemical processes and environmental changes. However, geochemical data have high-dimensional, nonlinear characteristics, and traditional geochemical data analysis methods have struggled to meet the demands of modern science. Nowadays, the development of big data and artificial intelligence technologies has provided new ideas and methods for geochemical data analysis. However, geochemical research involves numerous fields such as petrology, ore deposit, mineralogy, and others, each with its specific research methods and objectives, making it difficult to strike a balance between depth and breadth of investigation. Additionally, due to limitations in data sources and collection methods, existing studies often focus on a specific discipline or issue, lacking a comprehensive understanding of the bigger picture and foresight for the future. To assist geochemists in identifying research hotspots in the field and exploring solutions to the aforementioned issues, this article comprehensively reviews related studies in recent years, elaborates on the necessity and challenges of combining geochemistry and artificial intelligence, and analyzes the characteristics and research hotspots of the global collaboration network in this field. The study reveals that the investigation into artificial intelligence techniques to address geochemical issues is progressing swiftly. Joint research papers serve as the primary means of contact within a worldwide collaborative network. The primary areas of focus in the ongoing research on the integration of geochemistry and artificial intelligence include methodologies for analyzing geochemical data, environmental modifications, and mineral prospectivity mapping. Geochemical data analysis is currently a significant focus of research, encompassing a range of methods including machine learning and deep learning. Predicting mineral resources for deep space, deep Earth, and deep sea is also a pressing topic in contemporary research. This paper explores the factors driving research interest and future trends, identifies current research challenges, and considers opportunities for future research.

Termo–mekanik yoğunlaştırma işleminin ahşap malzemenin fiziksel özellikleri üzerine etkisi

It can be made into high strength, and valuable products by compacting low density, and low commercial value wood species. In this study, black pine (Pinus nigra) and Uludağ fir (Abies nordmanniana subsp. bornmulleriana) tree species were densified by using Thermo-mechanical (TM) method, which is an environmental modification method, at 140 oC and two different ratios of 25% and 50% (in the radial direction). Compression ratio in air-dry moisture, spring-back ratio after densification, and physical properties of air-dry densities were determined. The obtained data were subjected to statistical analysis in the MSTAT-C program. According to the results, wood type, densification type, and all their interactions were found to be effective on the compression ratio, and spring-back ratio in air dry moisture. The compression ratio in air-dried moisture was lower in Uludağ fir (Uludağ fir: 0.40 gr/cm³, black pine: 0.49 gr/cm³) compared to black pine due to the spring-back effect. While the volumetric recovery (spring-back) rates were 15.44% in Uludağ fir, it was determined as 19.40% in black pine. After the condensation process, the air-dry density value increase was lower in black pine compared to Uludağ fir, and it was determined as 35.94% in Uludağ fir and 34.53% in Black Pine

Effectiveness of a workshop-based intervention to reduce bullying and violence at work: A 2-year quasi-experimental intervention study

IntroductionBullying and violence at work are associated with reduced wellbeing of the victims, but few evidence-based interventions are available to prevent these offensive behaviours. We developed and examined the effectiveness of an intervention aimed at prevention of bullying and violence at work through modifications in psychosocial work environment. MethodsIn accordance with pre-published protocol, employees and supervisors of 12 work units in 3 cities (intervention group A: n = 315; intervention group B: n = 271) received a workshop-based intervention on organizational practices to prevent bullying and violence, including supervisor support, supervisor justice, workplace social capital, and psychological safety and were compared to a reference group (n = 2310) which did not receive the intervention. Latent change score modelling (LCSM) was used to estimate between- and within-individual differences in changes of organizational practices and prevalence of bullying and violence from baseline (2020) to follow-up (2022). ResultsNo direct or indirect effects of intervention were observed. Of the potential mediator variables, supervisor support (B = 0.04; 95% confidence interval 0.006, 0.07) and supervisor justice (0.04; 0.01, 0.08) improved in the intervention group B between the measurements and compared to control group, but the result was not replicated in intervention group A. No changes were observed between the measurement points in bullying or violence at work. ConclusionsNo intervention effects on bullying and violence at work were observed. It may be worthwhile to develop the intervention further to focus more on supervisor and co-worker relationships and on psychosocial resources of work team.

Thermal conditioning of quail embryos has transgenerational and reversible long-term effects

BackgroundIn the current context of global warming, thermal manipulation of avian embryos has received increasing attention as a strategy to promote heat tolerance in avian species by simply increasing the egg incubation temperature. However, because of their likely epigenetic origin, thermal manipulation effects may last more than one generation with consequences for the poultry industry. In this work, a multigenerational and transgenerational analysis of thermal manipulation during embryogenesis was performed to uncover the long-term effects of such procedure.ResultsThermal manipulation repeated during 4 generations had an effect on hatchability, body weight, and weight of eggs laid in Japanese quails, with some effects increasing in importance over generations. Moreover, the effects on body weight and egg weight could be transmitted transgenerationally, suggesting non-genetic inheritance mechanisms. This hypothesis is reinforced by the observed reversion of the effect on growth after five unexposed generations. Interestingly, a beneficial effect of thermal manipulation on heat tolerance was observed a few days after hatching, but this effect was not transgenerational.ConclusionsOur multigenerational study showed that thermal conditioning of quail embryos has a beneficial effect on post-hatch heat tolerance hampered by transgenerational but reversible defects on growth. Assuming that no genetic variability underlies these changes, this study provides the first demonstration of epigenetic inheritance of traits induced by environmental temperature modification associated with long-term impacts in an avian species.

Prevalence and associated factors of poor sleep quality among industrial workers in Addis Ababa, Ethiopia: findings from a cross-sectional study

ObjectiveThis study aimed to investigate the prevalence and associated factors of poor sleep quality among Bole Lemi Industrial Park workers in Addis Ababa, the capital of Ethiopia.DesignAn institution-based cross-sectional study...

Features of protein glycosylation in multiple sclerosis

The article presents an analytical review of the published data on the features of protein glycosylation in multiple sclerosis (MS). The search in the PubMed database with the keywords "multiple sclerosis, glycosylation", for the period of 2012-2022, resulted in 12 sources presenting the studies on N-glycosylated plasma proteins and immunoglobulins G in multiple sclerosis, clinically isolated syndrome, neuromyelitis optica spectrum disorders and meningitis of viral etiology in patients' cerebrospinal fluid and blood serum.
 The studies revealed specific changes in glycoproteins in multiple sclerosis. Glycome changes correlated with the age and sex of patients, with the clinical form of the disease, as well as with the degree of disability on the EDSS scale. These findings can contribute to the early diagnosis of MS, the definition of the form of the disease and its course prediction.
 Given the diversity of the glycome expression, the differences in its modifications in different environments (serum and blood plasma, cerebrospinal fluid), as well as the variety of approaches to its study (many quantitative and qualitative biochemical methods), there is a prospect of further search for markers and predictors of the course of multiple sclerosis.

Cognitive dysfunction in post-COVID-19 condition: Mechanisms, management, and rehabilitation.

The long-term effects of COVID-19 on cognitive function have become an area of increasing concern. This paper provides an overview of characteristics, risk factors, possible mechanisms, and management strategies for cognitive dysfunction in post-COVID-19 condition (PCC). Prolonged cognitive dysfunction is one of the most common impairments in PCC, affecting between 17% and 28% of the individuals more than 12 weeks after the infection and persisting in some cases for several years. Cognitive dysfunctions can be manifested as a wide range of symptoms including memory impairment, attention deficit, executive dysfunction, and reduced processing speed. Risk factors for developing PCC, with or without cognitive impairments, include advanced age, preexisting medical conditions, and the severity of acute illness. The underlying mechanisms remain unclear, but proposed contributors include neuroinflammation, hypoxia, vascular damage, and latent virus reactivation not excluding the possibility of direct viral invasion of the central nervous system, illustrating complex viral pathology. As the individual variation of the cognitive impairments is large, a neuropsychological examination and a person-centered multidimensional approach are required. According to the World Health Organization, limited evidence on COVID-19-related cognitive impairments necessitates implementing rehabilitation interventions from established practices of similar conditions. Psychoeducation and compensatory skills training are recommended. Assistive products and environmental modifications adapted to individual needs might be helpful. In specific attention- and working memory dysfunctions, cognitive training-carefully monitored for intensity-might be effective for people who do not suffer from post-exertional malaise. Further research is crucial for evidence-based interventions specific to COVID-19-related cognitive impairments.

A Systematic Review on the Viruses of Anopheles Mosquitoes: The Potential Importance for Public Health.

Anopheles mosquitoes are the vectors of Plasmodium, the etiological agent of malaria. In addition, Anopheles funestus and Anopheles gambiae are the main vectors of the O'nyong-nyong virus. However, research on the viruses carried by Anopheles is scarce; thus, the possible transmission of viruses by Anopheles is still unexplored. This systematic review was carried out to identify studies that report viruses in natural populations of Anopheles or virus infection and transmission in laboratory-reared mosquitoes. The databases reviewed were EBSCO-Host, Google Scholar, Science Direct, Scopus and PubMed. After the identification and screening of candidate articles, a total of 203 original studies were included that reported on a variety of viruses detected in Anopheles natural populations. In total, 161 viruses in 54 species from 41 countries worldwide were registered. In laboratory studies, 28 viruses in 15 Anopheles species were evaluated for mosquito viral transmission capacity or viral infection. The viruses reported in Anopheles encompassed 25 viral families and included arboviruses, probable arboviruses and Insect-Specific Viruses (ISVs). Insights after performing this review include the need for (1) a better understanding of Anopheles-viral interactions, (2) characterizing the Anopheles virome-considering the public health importance of the viruses potentially transmitted by Anopheles and the significance of finding viruses with biological control activity-and (3) performing virological surveillance in natural populations of Anopheles, especially in the current context of environmental modifications that may potentiate the expansion of the Anopheles species distribution.

Modifying physical activities for maximizing learning opportunities: perspectives of Finnish physical educators and special educators on inclusive teaching strategies

ABSTRACT Background Recent curricular reforms have aimed to make the Finnish education system more inclusive which requires the implementation of differentiated and individualized teaching practices within schools. In Finland, as it is internationally, efforts have been made to increase adaptive teaching strategies and collaborative practices between different professionals in the physical education (PE) context. So far, current research has revealed significant findings on how pupils with special educational needs and disabilities (SEND) can be successfully included in integrated/mainstream PE settings, focusing mainly on the perspectives of PE teachers. In comparison, little attention has been paid to the instructional strategies of different pedagogues involved in the PE classroom. Besides, little is known about how inclusive learning environments with an all-embracing approach that goes beyond the inclusion of pupils with SEND can be created in practice. Paying greater attention to these issues holds strong potential to enrich the existing knowledge regarding instructional strategies in PE and could help other teachers justify their educational choices. Methodology Drawing on the data from a multiple case study in a Finnish context, we explore how four PE teachers and four special education teachers attempted to work inclusively within PE. Document analysis of the current Finnish national curriculum and semi-structured interviews with special and physical education teachers were used to extend the current understanding of pedagogical practices for dealing with diversity in PE. The interviews have been content-analysed adopting deductive-inductive approach utilizing the TREE model and the Inclusion Spectrum. Findings The results of the present study illuminate how PE and special educators often showed willingness to modify the physical activities to meet the individual needs of all learners in PE which included the rules, equipment, and environmental modifications. The findings highlight the variety of instructional strategies used among participants in the PE context. Both teacher professions take individual responsibility for the teaching activities, but their traditional role as independent and autonomous professionals may also be an obstacle for collaboration. This research also identified the important role of collaborative structures and cultures which requires critical reflections of the individual aims and a shared vision of inclusive teaching. Conclusion Overall, this paper contributes to a growing body of pedagogical research portraying the perspectives of PE and special educators involved in the PE classroom. Future research should further examine the perspectives of different professionals as it may contribute to a more comprehensive perspective on diversity and inclusive teaching strategies.

Aerobic physical exercise modifies the prostate tumoral environment

Exercise is recognized for its potential role in reducing the risk of certain cancers. However, the molecular mechanisms behind this risk reduction are not fully understood. Here, we hypothesized that aerobic physical exercise induces cancer attenuating effects through the modulation of oxidative stress and inflammation. To test this hypothesis, twenty male Sprague Dawley rats with chemically induced prostate tumors were divided into two groups: Prostate cancer (PC) in the absence and presence of exercise (PC + Ex). Rats in the PC + Ex group performed exercises on a treadmill for 8 weeks, 5 sessions per week, at an intensity of 60 % of maximum capacity. Weight and feed efficiency, Ki-67, apoptosis, prostatic inflammation, and markers of oxidative stress were analyzed. We found that aerobic physical exercise significantly decreased prostate cell proliferation (p < 0.05) across modulation, tumor size, and prostate weight. The PC + Ex group also significantly reduced anti-apoptosis protein expression (p < 0.05) and increased pro-apoptotic protein expression. Furthermore, physical exercise increased enzymatic antioxidant defenses in the prostate, plasma, and whole blood. Moreover, PC + Ex reduced lipid peroxidation and protein carbonyl levels (p < 0.05). In the prostate, there was an increase in anti-inflammatory cytokines (IL-10), and a reduction in pro-inflammatory cytokines (IL-6, TNF-α, and NF-κB) after 8 weeks of physical exercise. In conclusion, we found that aerobic physical exercise is a functional, beneficial, and applicable approach to control PC progression, because it modifies the systemic environment, including the regulation of glucose and circulating lipids. This modification of the cancer cells environment has anti-inflammatory and antioxidant effects that attenuate tumor growth.

Precise Design and Modification Engineering of Single-Atom Catalytic Materials for Oxygen Reduction.

Due to their unique electronic and structural properties, single-atom catalytic materials (SACMs) hold great promise for the oxygen reduction reaction (ORR). Coordinating environmental and engineering strategies is the key to improving the ORR performance of SACMs. This review summarizes the latest research progress and breakthroughs of SACMs in the field of ORR catalysis. First, the research progress on the catalytic mechanism of SACMs acting on ORR is reviewed, including the latest research results on the origin of SACMs activity and the analysis of pre-adsorption mechanism. The study of the pre-adsorption mechanism is an important breakthrough direction to explore the origin of the high activity of SACMs and the practical and theoretical understanding of the catalytic process. Precise coordination environment modification, including in-plane, axial, and adjacent site modifications, can enhance the intrinsic catalytic activity of SACMs and promote the ORR process. Additionally, several engineering strategies are discussed, including multiple SACMs, high loading, and atomic site confinement. Multiple SACMs synergistically enhance catalytic activity and selectivity, while high loading can provide more active sites for catalytic reactions. Overall, this review provides important insights into the design of advanced catalysts for ORR.

Does changing learning environments affect student motivation?

BackgroundSelf-directed learning (SDL) has evolved as an adaptable educational environment, providing flexibility and individualization that meet students' psychological needs and enhance their educational experiences. In turn, these experiences significantly affect student motivation, reinforcing the crucial role of the learning environment in its promotion. To leverage the educational potential of SDL in synergy with traditional teacher-directed environments, in-depth research is vital. AimsGrounded in the Self-Determination Theory and Stage-Environment Fit Theory, this research employs longitudinal data to examine how modifications in learning environments influence students' basic needs and motivation. SampleThe research incorporated 754 German students, with an average age of 13.56 (SD = 1.2, 49.7% female). MethodOver the span of a year, the study scrutinized data from two distinct educational environments: self-directed learning (SDL) and teacher-directed instruction (TDI). The Latent Change Score Models were used for the data analysis, considering performance data, age, and gender. ResultsThe analysis showed an overall increase in students' basic need satisfaction during SDL. Conversely, TDI had no substantial effect on autonomy and social relatedness. An increase in intrinsic and identified motivation was noticed during SDL, while introjected and extrinsic motivation displayed a decreasing trend, particularly during SDL. These observations emphasize the qualitative differences between both environments. ConclusionThe findings suggest an integrated approach of SDL and TDI to mitigate the detected decrease in motivation. They highlight SDL's potential in shaping motivation and meeting basic needs and stress the importance of maintaining an optimal balance between SDL and TDI in different educational settings.

Preconditioning Concepts for the Therapeutic Use of Extracellular Vesicles Against Stroke.

Various preclinical stroke models have demonstrated the neuroprotective effects of extracellular vesicles (EVs) obtained from several types of cells, including neurons, astrocytes, microglia, neuronal progenitor cells, bone marrow stem cells, and mesenchymal stem cells. EVs interfere with key mechanisms in stroke pathophysiology such as cell death, neuroinflammation, autophagy, and angiogenesis. The mode of action and efficacy depend on the specific EV content, including miRNAs, proteins, and lipids, which can be modified through (I) bioengineering methods, (II) choice of source cells, and (III) modification of the source cell environment. Indeed, modifying the environment by preconditioning the EV-secreting cells with oxygen-glucose deprivation or medium modification revealed superior neuroprotective effects in stroke models. Although the concept of preconditioned EVs is relatively novel, it holds promise for the future treatment of ischemic stroke. Here, we give a brief overview about the main mechanisms of EV-induced neuroprotection and discuss the current status of preconditioning concepts for EV-treatment of ischemic stroke.

The Intertwining Roads between Psychological Distress and Gut Microbiota in Inflammatory Bowel Disease.

Inflammatory bowel disease represents one of the most life-altering gastrointestinal pathologies, with its multifactorial nature and unclear physiopathology. The most relevant clinical forms, ulcerative colitis and Crohn's disease, clinically manifest with mild to severe flares and remission periods that alter the patient's social, familial and professional integration. The chronic inflammatory activity of the intestinal wall determines severe modifications of the local environment, such as dysbiosis, enteric endocrine, nervous and immune system disruptions and intestinal wall permeability changes. These features are part of the gastrointestinal ecosystem that modulates the bottom-to-top signaling to the central nervous system, leading to a neurobiologic imbalance and clinical affective and/or behavioral symptoms. The gut-brain link is a bidirectional pathway and psychological distress can also affect the central nervous system, which will alter the top-to-bottom regulation, leading to possible functional digestive symptoms and local inflammatory responses. In the middle of this neuro-gastrointestinal system, the microbiome is a key player, as its activities offer basic functional support for both relays. The present article presents current scientific information that links the pathophysiology and clinical aspects of inflammatory bowel disease and psychiatric symptomatology through the complex mechanism of the gut-brain axis and the modulatory effects of the gut microbiota.