The primary motivation of this paper is the lack of consensus on the impact of renewable energy (RE) and research and development (R&D) expenditure on CO2emissions in the literature. Current literature has mostly ignored the spillover effect of R&D on CO2emissions by increasing the intensity effect of technology, leading to biased results. Further, little is known about the impact of previous epidemics on CO2emissions. This study fills these gaps by evaluating the spillover effects of RE and R&D on CO2emissions in a global panel of54countries from2003to2017. Using a two-way time- and spatial-fixed-effects panel analysis, we find both income-induced and scale effects of economic growth are present in our panel, though the scale effect is the dominant one. Our findings indicate that economic growth increases CO2emissions at a decreasing rate, validating the Environmental Kuznets Curve hypothesis, and that urbanization and foreign trade worsen the environment. We also find that epidemic episodes before COVID-19had a nonsignificant impact on CO2emissions internationally. More importantly, our results confirm the presence of both the intensity and scale effects of R&D, with the intensity effect being the dominant one. We find overwhelming evidence that global R&D investment led to an overall (direct plus spillover) reduction of CO2emissions, driven by its spillover effect, through two channels: RE and economic growth. Finally, we find that RE installations assist with reducing CO2emissions internationally, though RE composition and state of R&D can lead to different findings. Our findings have significant policy implications for sustainable development. Our RE and R&D-spillover results support the policy recommendation of shifting to high-tech clean energy sources.