Environmental Influences Research Articles

Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders.

Cognitive impairment is a leading component of several neurodegenerative and neurodevelopmental diseases, profoundly impacting on the individual, the family, and society at large. Cognitive pathologies are driven by a multiplicity of factors, from genetic mutations and genetic risk factors, neurotransmitter-associated dysfunction, abnormal connectomics at the level of local neuronal circuits and broader brain networks, to environmental influences able to modulate some of the endogenous factors. Otherwise healthy older adults can be expected to experience some degree of mild cognitive impairment, some of which fall into the category of subjective cognitive deficits in clinical practice, while many neurodevelopmental and neurodegenerative diseases course with more profound alterations of cognition, particularly within the spectrum of the dementias. Our knowledge of the underlying neuropathological mechanisms at the root of this ample palette of clinical entities is far from complete. This review looks at current knowledge on synaptic modifications in the context of cognitive function along healthy ageing and cognitive dysfunction in disease, providing insight into differential diagnostic elements in the wide range of synapse alterations, from those associated with the mild cognitive changes of physiological senescence to the more profound abnormalities occurring at advanced clinical stages of dementia. I propose the term "cognitive synaptopathy" to encompass the wide spectrum of synaptic pathologies associated with higher brain function disorders.

When failure is the option: Unravelling sexual assault outcomes

We investigate the concept of “criminal failure” in sexual crimes and the relevance of various theoretical frameworks for its understanding: individual offender's rational choice, environmental influences and routine activities, victimological characteristics from lifestyle theory, and crime interaction factors. We examined a sample of 1121 “failed” cases (i.e., attempted but not completed) and 1500 “successful” cases (i.e., completed) of sexual assault that occurred in France between 1990 and 2018. We used 32 predictors that mapped on the four theoretical frameworks and conducted bivariate followed by multivariate analyses. Multiple theoretical frameworks are relevant to understand criminal failure, which is a product of perpetrator, environmental, victimological, and interactional factors. Two distinct patterns are specifically associated with failure: lack of preparation and lack of social skills. In addition, failure was best understood not as a unitary concept, but as multifactorial by distinguishing between different types of failure, specifically: offender intentionally released the victim before completion, victim escaped or third party rescue. Finally, patterns of failure were different in sexual crimes against children compared to those against adults. Criminology should pay closer attention to failure in crime. This understudied area can yield important theoretical knowledge and practical implications regarding the prevention of sexual crimes.

Twin Data Support a Sensitive Period for Singing Ability.

As with many other musical traits, the social environment is a key influence on the development of singing ability. While the familial singing environment is likely to be formative, its role relative to other environmental influences such as training is unclear. We used structural equation modeling to test relationships among demographic characteristics, familial environmental variables (early and current singing with family), vocal training, and singing ability in a large, previously documented sample of Australian twins (N = 1163). Notably, early singing with family, and to a lesser extent vocal training, predicted singing ability, whereas current singing with family did not. Early familial singing also mediated the relationship between sex and singing ability, with men who sang less with family during childhood showing poorer ability. Bivariate twin models between early familial singing and singing ability showed the phenotypic correlation was largely explained by shared environmental influences. This raises the possibility of a sensitive period for singing ability, with sociocultural expectations around singing potentially differentiating the developmental trajectories of this skill for men and women.

Zygosity Effects on Human Voice: Fundamental Frequency Analysis of Brazilian Twins' Speech.

Voice production can be influenced by interindividual variations related to genetic, physiological, behavioral, and several environmental factors. Here we examined the effect of zygosity on speaking fundamental frequency (F0) statistical descriptors. Our aims were: (1) to determine whether the genetic similarity between monozygotic (MZ) and dizygotic (DZ) twins affects F0 characteristics, and (2) to quantify the contribution of genetic factors to these characteristics. The study involved 79 same-sex twin pairs of Brazilian Portuguese speakers, comprising 65 MZ and 14 DZ twins, aged 18 to 66 years (31.7 ± 11.6 years), with 21 male and 58 female pairs. Participants were recorded while uttering a greeting phrase and the Brazilian Portuguese version of the 'Happy Birthday to You' song. Speech segments were analyzed using Praat free software, and F0 measures were automatically extracted in both Hertz and semitone scales. Statistical descriptors, including centrality, dispersion, and extreme values of F0 were examined, and the ACE model (i.e., total genetic effects, A; shared environmental influences, C; and nonshared environmental influences, E) was employed to estimate the additive effect;ts of monozygosity. As anticipated, we observed a zygosity effect on several F0 parameters, with more similarity between MZ twins compared to DZ twins. We discuss the genetic influences on F0 parameters and the absence of a monozygosity effect in two of them. Additionally, we briefly address potential biases associated with the selected measurement scale for statistical modeling. Finally, we explore the influence of genetic factors on F0 patterns, as well as environmental, life history and linguistic factors, particularly concerning F0 variation in speech.

What explains the sex differences in family leisure activities of children? A genetically sensitive analysis with twin data

Objective: This paper examines to what extent genetic and environmental influences contribute to differences in family leisure activities of girls and boys. Background: While family leisure activities have been described as relevant for child development, it remains unclear what accounts for differences in the leisure behavior of girls and boys. While research emphasized the importance of the environment, e.g., in relation to gender role socialization, other studies pointed to biological and, thus, genetic differences as explanatory factors. Method: The analysis is based on 954 female and 1036 male twins aged 10-12 years who are part of the first wave of the German Twin Family Panel Study. Our analysis examines five family leisure activities using variance decompositions and gene-environment interaction models. Results: Overall, there were only minor differences between girls and boys in the contributions of genes and environments to family leisure activities. Only for singing and making music did influences from the environment common to both twins contribute more strongly to the performance of these activities in the girls than in the boys. Conclusion: There is no evidence that genetic differences lead to differences in family leisure behavior between girls and boys in the activities considered here. Existing differences are more likely to be due to environmental influences.

The Influence of Work Environment, Management Support, Organizational Culture, and Employee Engagement on Employee Performance Through Employee Satisfaction

In an era of globalization, companies must optimize their resources to meet customer needs. To improve the quality of human resources, companies must focus on areas such as the work environment, management support, organizational culture, employee engagement, and employee satisfaction. The study aims to identify the employee's performance in relation to its association with the variable studied and analyze it based on the supporting component. Data collection occurs through surveys and questionnaires, while analysis methods include Structural Equation Modeling (SEM). The results showed that a significant relationship between employee performance and employee characteristics on the work environment variable of 0.473 and employer engagement of 0.440 has been demonstrated. Employees who work in a positive and supportive work environment and feel engaged in their work tend to be more committed, more productive and qualified, more satisfied and motivated, and have a positive work culture. These aspects have the ability to increase employee satisfaction and employee performance, which in turn contribute to the overall success of the company.

Green bonds in the Russian market: Assessing environmental influence on returns

In this paper, we study whether the environmental characteristics of assets influence their returns in the case of the Russian bond market. Our main goal for this study was to research this issue for Russia using the same methodology as in studies for developed markets to allow for comparison of results. We use the twin bond methodology and consider expected returns. Our main hypothesis is that brown (i.e., non-green) assets should have a higher yield compared to green ones. Indeed, we find, predictably, that green bonds have a lower yield to maturity. This result is in line with previous results for other markets and suggests that green financing might be cheaper for companies.

Nitrogen use efficiency of open-pollinated maize cultivars and topcrosses under low nitrogen soil

The study was conducted to evaluate the nitrogen utilization efficiency (NUE) of open-pollinated maize cultivars under low nitrogen soil conditions. It took place at the Lower Niger River Basin Development Authority in Ilorin, Nigeria, during the 2019 and 2020 cropping seasons. The nitrogen treatments (0, 45, and 90 kg N ha⁻1) were assigned as the main plots, while the genotypes were designated as sub-plots in a split-plot design. The NUE of open-pollinated varieties (OPVs) and Topcrosses significantly increased with the application of 45 kg of nitrogen per hectare compared to 0 kg. Similarly, the maize grain yield for both OPVs and Topcrosses ranged from 1.40 to 3.57 t ha⁻1 and from 1.07 to 2.64 t ha⁻1 across the two years with the application of 45 kg of nitrogen per hectare compared to 0 kg. With the exception of days to 50 % silking, all other traits tested exhibited a significant correlation with grain yield. A gene pool for tolerance to low nitrogen may have been present in the cultivars Dmr-Esr Y Cif 2 and Acr 95 Tze Comp 4C3, which combined well with other cultivars to produce high grain yield and NUE. Topcrosses, including Ev Dt-Y 2000 Str C0 × Tze-W Dt Str C4, Dmr-Esr Y Cif 2 × Acr 95 Tze Comp 4C3, Ak 95 Dmr-Esrw × Tzb Rel D4 CO-W, Dmr-Esr Y Cif 2 × Tze-W Dt Str C4, and Br 9922 Dmr Sr × Ev Dt-Y 2000 Str C0, also demonstrated strong potential for maize grain yield and NUE. This suggests that these crosses could serve as promising candidates for developing low nitrogen tolerance in maize for low nitrogen soil environments. A positive relationship between fertilizer levels, NUE, and grain yield indicates that proper nitrogen fertilizer management can enhance both NUE and the grain yield of maize genotypes. Genetic analysis revealed that both phenotypic coefficient of variation (PCV) and environmental variance (δ2p) were higher than genotypic coefficient of variation (GCV) and genetic variance (δ2g), suggesting that environmental influences were more significant than genetic factors for the tested traits. Consequently, improving these traits may be achieved by manipulating environmental conditions.

Exploring Bark‐Water Interaction Effects on Stemflow Nutrient Concentrations in Urban Trees

ABSTRACTThis study investigates the influence of bark properties on nutrient fluxes in urban environments, focusing on the relationship between bark wettability, chemical composition, and the concentrations of nutrients in stemflow and adjacent soil across eight urban tree species. Through a comprehensive analysis involving chemical assays and ecohydrological measurements, we explored how variations in bark characteristics affect water interaction and subsequent chemical dynamics within urban landscapes. Contrary to the initial hypothesis that bark properties would significantly influence nutrient flux, results revealed a complex scenario where environmental and anthropogenic factors in urban settings seemingly overshadow the direct impact of bark characteristics on nutrient dynamics. Our findings indicate that while bark properties such as wettability and chemical composition do vary among tree species, these variations do not directly correlate with significant differences in stemflow or soil nutrient concentrations. This suggests a homogenising effect of urban environments on ecohydrological processes, highlighting the need for a broader understanding of urban forest ecology that incorporates both biological traits and urban‐specific environmental influences. This research contributes to the field of urban ecohydrology by underscoring the complexity of nutrient fluxes in urban forests and suggesting that effective urban tree management requires an integrated approach that considers the interplay between tree physiological traits and urban environmental conditions. Our study calls for further research to unravel the intricate dynamics of urban ecosystems, aiming to enhance the sustainability and ecological benefits of urban forests.

Gestational exposure to organophosphate ester flame retardants and risk of childhood obesity in the environmental influences on child health outcomes consortium

Introduction: Organophosphate esters (OPEs) are increasing in use as flame retardants and plasticizers and concerns have been raised given their endocrine-disrupting activities and possible obesogenic consequences. However, longitudinal studies on gestational OPE exposure and childhood obesity are scarce. This study examined whether OPE levels in maternal urine during pregnancy were associated with the risk of childhood obesity. Methods: OPEs were analyzed in pregnancy urine samples of 5,087 individuals from 14 studies contributing to the Environmental influences on Child Health Outcomes (ECHO) Cohort. BDCPP, DBUP/DIBP, and DPHP, detected in > 80 % of the samples, were modeled continuously and by tertiles; whereas BCPP, BBOEP, and BCETP, detected in 50–80 % of samples, were modeled categorically (not-detected, low, and high). Childhood obesity was defined by BMI z-score ≥ 95th percentile according to WHO (<2 years) and the CDC (≥2 years) metrics. Adjusted modified Poisson regression models assessed childhood obesity risk and the mixture effect was assessed using Bayesian kernel machine regression (BKMR). Results: BMI measurements were available for 3,827 children in infancy (0.5–1.9 years), 3,921 children in early childhood (2.0–4.9 years), and 2,541 children in mid-childhood (5.0–10.0 years). Obesity was present in 16–21 % of children across age groups. In mid-childhood DBUP/DIBP second and third versus first tertiles were associated with increased obesity risk (RR 1.14; 95 % CI: 1.02, 1.28; and RR 1.11; 95 % CI: 0.97, 1.27; respectively); whereas BDCPP second and third versus first tertiles reflected an inverse association with obesity risk (RR 0.85; 95 % CI: 0.80, 0.91 and RR 0.91; 95 % CI: 0.77, 1.07; respectively). No association with obesity risk was observed for DPHP, BCPP, BBOEP, and BCETP. Directions observed were consistent with those seen in BKMR models. Conclusions: This study identified mixed associations between gestational OPE exposure and childhood obesity. Further investigation across a comprehensive range of OPE exposures is warranted.

A systematic literature review on occupational accident factors in the rail construction industry: lessons learned from a quarter-century of studies globally.

The rail construction industry is notable for its large scale, substantial investment, extensive stakeholders involvement, long construction period, and intricate operation and technology. This industry is among the most dangerous due to the highest number of occupational accident cases worldwide. Therefore, it is crucial to analyse and identify the existing literature on occupational accident factors in rail construction. To address the research aim, the study identified the factors that contribute to occupational accidents using systematic review methodology. This systematic literature review adheres to the rigorous Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement. Relevant publications from the past 25 years were retrieved from Scopus, Web of Science (WoS), and Science Direct electronic databases. Through a meticulous review of 43 selected publications, five accident factor themes were discovered: worker, workplace, materials and equipment, organizational, and environmental influences. The detailed analysis of these themes has led to the identification of 19 specific sub-factors within these categories, providing a granular understanding of the intricate elements contributing to accidents. This study offers a foundational understanding of accident factors in the rail construction industry, paving the way for targeted OSH interventions aimed at preventing occupational accidents in the future.

Density of Limnoperna fortunei larval stages in a cascade of subtropical reservoirs: spatiotemporal variation and environmental influences.

The golden mussel (Limnoperna fortunei) is an invasive bivalve that has established itself in several South American river systems, impacting ecosystem functioning. Reservoir cascades provide their larvae with the means of rapid dispersal, but the relationship between environmental variables and larval stage structure remains unclear. In this study, the density of three L. fortunei larval stages and quantitative detection using DNA are analyzed in a cascade of five reservoirs in the upper Uruguay River Basin and associated with spatiotemporal variation in environmental parameters. The analysis of L. fortunei eDNA presence and absence in freshwater systems appears to be a valuable mapping tool; however, no significant link was found between the eDNA magnitude and the overall larval density. The increase in larval density was related to the fluctuation of environmental parameters over a year, with the highest average larval densities observed in the CN and ITA reservoirs, though no significant difference was observed between the five reservoirs, where D-shaped larvae predominated. During winter, larval density decreased significantly, however, other variables also contribute to species activity and development in the upper Uruguay River Basin reservoirs and may be considered limiting factors. The relationships between environmental parameters were evaluated using a multivariate model. The interaction between reservoir area and precipitation, water temperature, electrical conductivity, and dissolved oxygen had a significant effect on larval density but showed specific influences on each larval stage. Any increase in density was regulated by dissolved oxygen and electrical conductivity content at all larval stages. Furthermore, total phosphorus affected the density of F1 and F3 larvae. The interaction between reservoir area and precipitation, nitrate content, phosphate concentrations, and water temperature had the most influence on the density of F2 and F3 larval stages; the F1 stage was mainly affected by calcium concentrations. The isolated effect of precipitation also contributed to the density of F2 and F3 larvae. Our findings shed light on the interaction between different phases of golden mussel larvae and the main nutrients found in reservoirs, which may be a determining factor in the rise in density of the non-native species in these systems.

Understanding healthcare professionals’ responses to patient complaints in secondary and tertiary care in the UK: A systematic review and behavioural analysis using the Theoretical Domains Framework

BackgroundThe path of a complaint and patient satisfaction with complaint resolution is often dependent on the responses of healthcare professionals (HCPs). It is therefore important to understand the influences shaping HCP behaviour. This systematic review aimed to (1) identify the key actors, behaviours and factors influencing HCPs’ responses to complaints, and (2) apply behavioural science frameworks to classify these influences and provide recommendations for more effective complaints handling behaviours.MethodsA systematic literature review of UK published and unpublished (so-called grey literature) studies was conducted (PROSPERO registration: CRD42022301980). Five electronic databases [Scopus, MEDLINE/Ovid, Embase, Cumulated Index to Nursing and Allied Health Literature (CINAHL) and Health Management Information Consortium (HMIC)] were searched up to September 2021. Eligibility criteria included studies reporting primary data, conducted in secondary and tertiary care, written in English and published between 2001 and 2021 (studies from primary care, mental health, forensic, paediatric or dental care services were excluded). Extracted data included study characteristics, participant quotations from qualitative studies, results from questionnaire and survey studies, case studies reported in commentaries and descriptions, and summaries of results from reports. Data were synthesized narratively using inductive thematic analysis, followed by deductive mapping to the Theoretical Domains Framework (TDF).ResultsIn all, 22 articles and three reports met the inclusion criteria. A total of 8 actors, 22 behaviours and 24 influences on behaviour were found. Key factors influencing effective handling of complaints included HCPs’ knowledge of procedures, communication skills and training, available time and resources, inherent contradictions within the role, role authority, HCPs’ beliefs about their ability to handle complaints, beliefs about the value of complaints, managerial and peer support and organizational culture and emotions. Themes mapped onto nine TDF domains: knowledge, skills, environmental context and resources, social/professional role and identity, social influences, beliefs about capability, intentions and beliefs about consequences and emotions. Recommendations were generated using the Behaviour Change Wheel approach.ConclusionsThrough the application of behavioural science, we identified a wide range of individual, social/organizational and environmental influences on complaints handling. Our behavioural analysis informed recommendations for future intervention strategies, with particular emphasis on reframing and building on the positive aspects of complaints as an underutilized source of feedback at an individual and organizational level.

Systemic Perspective on Companies and the Digital Transformation: A Prototypical Methodological Approach as a Solution to Complex Business Problems

Due to changing market conditions, customer needs and environmental influences, organisations are facing increased pressure to transform in today’s world. The consequences of the COVID-19 pandemic have made many organisations aware of the importance of digital transformation in order to remain successful even in times of disruptive change. However, the pandemic has also shown how connected and complex the world is. The aim of this work is to answer the question of what a possible systematic method for dealing with complex business problems might look like. Dealing with complexity is a critical factor for any organisation and determines how resilient it can position itself in the face of dynamic environmental influences. To answer the research question, a prototype was first developed based on Niklas Luhmann’s systems theory, from which a systematic method was derived. The prototypes were then further developed and validated in qualitative expert interviews. A systems theory approach was chosen because it claims to construct a holistic picture of the company as a social system and thus to capture the interactions of all system components. Qualitative interviews based on a semi-standardised approach were used to test the prototypes for comprehensibility, applicability, and validity. German experts in the fields of system technology, change management and digital transformation were interviewed.

Modeling of Parkinson's Disease in Different Models.

Parkinson's Disease (PD) is a progressive disorder worldwide and its etiology remains unidentified. Over the last few decades, animal models of PD have been extensively utilized to explore the development and mechanisms of this neurodegenerative condition. Toxic and transgenic animal models for PD possess unique characteristics and constraints, necessitating careful consideration when selecting the appropriate model for research purposes. Animal models have played a significant role in uncovering the causes and development of PD, including its cellular and molecular processes. These models suggest that the disorder arises from intricate interplays between genetic predispositions and environmental influences. Every model possesses its unique set of strengths and weaknesses. This review provides a critical examination of animal models for PD and compares them with the features observed in the human manifestation of the disease.

S780 Examining the Influence of Food Environment and Socioeconomic Factors on Diabetic Gastroparesis Disease Severity

S780 Examining the Influence of Food Environment and Socioeconomic Factors on Diabetic Gastroparesis Disease Severity

PENGARUH DISIPLIN KERJA DAN LINGKUNGAN KERJA TERHADAP PRODUKTIVITAS PEGAWAI PADA KANTOR DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN TORAJA UTARA

This research aims to test and determine the influence of work discipline and work environment on employee productivity at the North Toraja Regency Population and Civil Registration Service Office. This research method uses quantitative research. Data collection techniques were through questionnaires. The population and sample in this study were all employees at the Population and Civil Registration Office of North Toraja Regency. Data were analyzed using the SPSS 26 program.The calculation results from the t test on the work discipline variable t count 3,420&gt; t table 1,688 and on the work environment variable the t count value 10,055 &gt; t table 1,688. This research shows that, partially work discipline has an effect on employee productivity, the work environment has an effect on employee productivity and simultaneously work discipline and work environment influence employee productivity at the North Toraja Regency Population and Civil Registration Service Office.

Navigating trust and health in India: the influence of social status and neighbourhood environment

BackgroundThe research on the relationship between interpersonal trust and health has primarily focused on Western contexts, with scarce attention in developing contexts. Addressing this gap, the study examines the association between interpersonal trust (both generalised and particularised) and health outcomes (self-rated health /SRH, and depression) among Indian adults, considering the moderating roles of social statuses (gender and caste) and macro-level factors like district-level income inequality.MethodsThe study draws on data from the World Health Organization's (WHO) Study on global AGEing and adult health (SAGE) Wave-1, collected between 2007 and 2010. This dataset provides a comprehensive overview of health outcomes, including self-rated health (SRH) and depression, socio-cultural status of adults aged 18 and above in India. Additionally, district-level data on income inequality, quantified through the Gini index, were incorporated to examine the influence of contextual socioeconomic influence on the trust-health relationship. Multilevel regression analysis with interaction effects with social statuses and income inequality at district was employed in the analysis to investigate the intricate relationship between interpersonal trust (both generalised and particularised) and health outcomes.ResultsThe study reveals that while generalised trust does not directly influence depression or SRH, particularised trust acts as a protective factor for both health outcomes. Gender-specific interaction effect shows that generalised trust reduces depression among males and improves SRH among females. Notably, caste does not significantly moderate the trust-health relationship. High district-level income inequality, however, modifies these associations: generalised trust is associated with improved SRH in areas of high inequality, whereas particularised trust correlates with increased depression in these districts.ConclusionThe findings highlight the complex dynamics between interpersonal trust, social status, and income inequality in shaping health outcomes in India. Generalised trust emerges as a potential buffer against the health-detrimental effects of income inequality, providing crucial insights for developing targeted health interventions. These results offer valuable guidance for global health policymakers and practitioners in effectively allocating development aid to enhance health outcomes, especially among the most marginalised groups.

The influence of work team and work environment on the character of loyalty to the organization (Study at the Hikmah Masamba General Hospital)

The influence of work team and work environment on the character of loyalty to the organization (Study at the Hikmah Masamba General Hospital)

Variation in the thermal plasticity of avian embryos is produced by the developmental environment, not genes.

Limited evidence suggests that variation in phenotypic plasticity within populations may arise largely from environmental sources, thereby constraining its evolvability. This is of concern for temperature-sensitive metabolism in the face of climate change. We quantified the relative influence of the developmental environment versus genes on the metabolic plasticity of avian embryos to temperature. We partially cross-fostered 602 house sparrow eggs (Passer domesticus), measured the heart rate plasticity of these embryos to egg temperature and partitioned variance in plasticity. We found that the foster (incubation) environment was the sole meaningful source of variance in embryonic plasticity (not genes, pre-laying effects or ambient conditions). In contrast to heart rate plasticity, offspring growth was influenced by the foster environment, genes/pre-laying parental effects and ambient conditions. Although embryonic plasticity to temperature varied in this population, these results suggest that it is unlikely to evolve quickly. Nevertheless, the expression of this plasticity may be able to shift between generations in response to changes in the developmental environment. Whether the multidimensional plasticity of heart rate to both current temperature and the developmental environment is itself an adaptive, evolved trait allowing avian embryos to optimize their metabolic plasticity to their current environment remains to be tested.