Environmental Health Risk Assessment Research Articles

Chemical and Colloidal Dynamics of MnO2 Nanosheets in Biological Media Relevant for Nanosafety Assessment.

Many layered crystal phases can be exfoliated or assembled into ultrathin 2D nanosheets with novel properties not achievable by particulate or fibrous nanoforms. Among these 2D materials are manganese dioxide (MnO2 ) nanosheets, which have applications in batteries, catalysts, and biomedical probes. A novel feature of MnO2 is its sensitivity to chemical reduction leading to dissolution and Mn2+ release. Biodissolution is critical for nanosafety assessment of 2D materials, but the timing and location of MnO2 biodissolution in environmental or occupational exposure scenarios are poorly understood. This work investigates the chemical and colloidal dynamics of MnO2 nanosheets in biological media for environmental and human health risk assessment. MnO2 nanosheets are insoluble in most aqueous phases, but react with strong and weak reducing agents in biological fluid environments. In vitro, reductive dissolution can be slow enough in cell culture media for MnO2 internalization by cells in the form of intact nanosheets, which localize in vacuoles, react to deplete intracellular glutathione, and induce cytotoxicity that is likely mediated by intracellular Mn2+ release. The results are used to classify MnO2 nanosheets within a new hazard screening framework for 2D materials, and the implications of MnO2 transformations for nanotoxicity testing and nanosafety assessment are discussed.

Fish as Indicators for Environmental Monitoring and Health Risk Assessment Regarding Aquatic Contamination with Pesticides

The proximity of water basins to anthropogenic sources of pollution affecting the state of nature also determines the need to study the ecosystems existing there. Fish are used as reliable indicators of pollution of the aquatic environment. Changes in the fish body make it possible to determine the toxicity of the contaminated water and the potential danger posed by anthropogenic substances that have entered it. In this regards, biomarkers are important assessment tools as they provide specific information on the biological effects of a particular toxicant. They can be used for monitoring purposes, as well as to clarify the link between the effects on the organism and the concentration of the contaminant in health risk assessment.

Environmental and human health risk assessment of trace metals in the mussel ecosystem from the Southwestern Mediterranean

This study evaluates the geographical distribution of Pb, Cd, Cr, Ni, Co, Cu, Zn, Mn and Fe in wild mussels Mytilus galloprovincialis as well as in associated suspended particulate matter (SPM) and sediments from the Algerian coast. The bioaccumulation (metal concentrations in tissue), bioavailability (metal indices) and bioconcentration of trace metals from the adjacent environment were assessed. The computed pollution load index (PLI) indicates that the sediments are not polluted by these metals, except for Zn which shows a moderate level of contamination. All the metals in SPM samples are in a ‘safe range’ with respect to the computed degree of contamination (DC < 2). The target hazard quotients (THQ) and the hazard index (HI) values indicate a risk level with Fe. However, the Cr measured in mussels is considered ‘extreme’, according to the consumption rate limit for mussels (CRlim) which limits their consumption to 0.5 kg/day.

Environmental and human health risk assessment of antibiotic residues in drinking water sources: case study of a fast-developing megacity in southern China

Abstract The occurrence, distribution, ecological and health risk assessment of five antibiotics (CFM, ERY, LCM, SMD and SMX) in 32 drinking water reservoirs of a megacity (Shenzhen) in Guangdong–Hong Kong–Macao Greater Bay Area (GBA), were investigated. Among the above antibiotics, CFM was not detected, ERY, SMD, LCM and SMX were detected in 65.6%, 46.9%, 43.7% and 40.6% of samples, with concentrations of 1.594–7.605 ng·L−1, 0.335–6.695 ng·L−1, 0.288–7.878 ng·L−1 and 0.770–5.355 ng·L−1, respectively. The maximum concentration of ERY was detected in GT Reservoir, and those of the other 3 antibiotics were detected in SZ Reservoir. The ecological risk quotient (RQ) values for SMX in SZ, XL, YT, EJ, SY, TG, XK, GK, MK and GT reservoirs ranged from 0.1 to 1.0, indicating a median risk to aquatic organisms, the others posed insignificant risk or low risk. Considering the joint effects of detected antibiotics, the highest overall RQ value was 0.38, obtained in SZ Reservoir, in other words, it was exposed to greater risk. Based on health risk assessment, the health RQ values for the detected antibiotics were significantly lower than 0.01, indicating insignificant risk to human health. These findings could provide a scientific basis for the government to ensure the drinking water safety of a megacity in GBA.

Environmental impact and health risk assessment of volatile organic compound emissions during different seasons in Beijing

Volatile organic compounds (VOCs) are major contributors to air pollution. Based on the emission characteristics of 99 VOCs that daily measured at 10 am in winter from 15 December 2015 to 17 January 2016 and in summer from 21 July to 25 August 2016 in Beijing, the environmental impact and health risk of VOC were assessed. In the winter polluted days, the secondary organic aerosol formation potential (SOAP) of VOC (199.70 ± 15.05 μg/m3) was significantly higher than that on other days. And aromatics were the primary contributor (98.03%) to the SOAP during the observation period. Additionally, the result of the ozone formation potential (OFP) showed that ethylene contributed the most to OFP in winter (26.00% and 27.64% on the normal and polluted days). In summer, however, acetaldehyde was the primary contributor to OFP (22.00% and 21.61% on the normal and polluted days). Simultaneously, study showed that hazard ratios and lifetime cancer risk values of acrolein, chloroform, benzene, 1,2-dichloroethane, acetaldehyde and 1,3-butadiene exceeded the thresholds established by USEPA, thereby presenting a health risk to the residents. Besides, the ratio of toluene-to-benzene indicated that vehicle exhausts were the main source of VOC pollution in Beijing. The ratio of m-/p-xylene-to-ethylbenzene demonstrated that there were more prominent atmospheric photochemical reactions in summer than that in winter. Finally, according to the potential source contribution function (PSCF) results, compared with local pollution sources, the spread of pollution from long-distance VOCs had a greater impact on Beijing.

The Behaviour of Open Defecation by Age Groups

In Indonesia, Open Defecationbehaviour can be found in all age groups starting from children to the elderly, both male and female. Community Based Total Sanitation Data (2018) recorded that the number of families who still practiced Open Defecation in Pekalongan Regency were as many as 51, 537 with open defecation access of 21.38%. The research aims to assess the median and trend of TheOpen Defecation Behaviour cases based on age groups. This research uses the nonreactive approachby referring to the secondary data from the result of Environmental Health Risk Assessment (EHRA) of Pekalongan District in 2017. The sampling unit is the households, in which respondents of 11, 400 were taken by multistage random sampling, spread across 19 sub-districts. Based on the calculation of Chi-Square Test for Trend for Binomial Proportions (Cochran-Armitage), the value of T1= 323.41798 >table of Chi-Square χ2= 3.84 (α=5%), there were 91, 200 individuals with a minimum number of Open Defecation Behaviour cases of 1, 943, a maximum number of 20, 857, and a median = 11, 400 (SD = 9, 242.844) which was estimated to be at the age of 50 years. The findings are that there is a trend in cases of Open Defecation Behaviouraccording to age groups. The trend is increasing among the adults.

Environmental health risk analysis due to PM10 during 2015’s smoke haze pollution in Sawahlunto City

This research was aimed to analyzed metal concentrations in particulate matter 10 (PM10) sampled from ambient air in Sawahlunto City during the occurrence of smoke-haze pollution in 2015. The metal contents comprise of Al, Cr, Mn, Co, Ni, and Cd, which represented the potential for both non-carcinogenic and carcinogenic illnesses. The obtained metal concentrations were further used to estimate health risk on human by using environmental health risk assessment approach. PM10 samplings were done by using Minivol Air Sampler while the metal concentration analysis was conducted by atomic absorption spectrophotometer after PM10 filter destruction. It was found out that during the smoke-haze pollution the PM10 concentrations were above Indonesian air quality standard and considered at hazardous level in accordance to the Indonesian air quality index. The results of environmental health risk assessment for children and adults show the Hazard Quotient (HQ) value > 1 for non-carcinogenic metals (Al, Cr, Mn). As for the carcinogenic metals (Co, Ni, Cd), it was estimated that the Excess Lifetime Cancer Risk (ELCR) > 10-6 for both children and adults. It can be concluded that the occurrence of smoke-haze pollution in Sawahlunto City in 2015 increased the risk of cancer illnesses in both children and adults due to the high metal concentrations in PM10.

Hydrogen Sulfide Exposure to Public Health Risk Around Cibereum Landfill Area at Banjar City

The process of spoilage of waste in the landfill produces air pollutant gases such as hydrogen sulfide (H2S) which was a colorless gas, highly flammable, and has a characteristic rotten egg odor. Communities around TPA who were continuously exposed to H2S gas has very at risk of experiencing health problems. The main entrance of H2S gas through the respiratory system so that it was quickly absorbed by the lungs rather than exposure through the mouth. This study aims to analyze the great health risks arising from exposure to hydrogen sulfide gas at the Cibeureum landfill in Banjar City. This research was a descriptive-analytic type with cross-sectional study design and it was analyzed with an environmental health risk assessment (EHRA) approach. The results of H2S concentration measurements were 0,004 ppm and still below the 0,02 ppm standard. Exposure projections indicate that people in the surrounding areas do not yet have non-carcinogenic risks (0,42≤1). The safe duration of exposure is 24 years. If residents still live around the landfill for more than 24 years, it will endanger them and cause non-carcinogenic health risks. Complaints caused by civilians around the landfill consist of coughing, headaches, colds, shortness of breath, chest pain, and sore throat.

Environmental and human health risk assessment of potentially toxic elements in soil, sediments, and ore-processing wastes from a mining area of southwestern Tunisia.

The occurrence and bioaccessibility of potentially toxic elements (PTEs) in soils and sediments are investigated by many studies, especially in territories exploited by mining and ore-processing activities, nearby agriculture-driven rural cities. Accordingly, the present study aimed at evaluating the geochemical properties, potential bioavailability, and risks for environment and human health of the most concerning PTEs of study area (Gafsa mining basin, Tunisia) such as Cd, Cr, and Zn in selected soil, sediment, and mining waste samples. The extraction of these solid matrixes by modified EU-BCR sequential extraction revealed that the most easily extractable fractions of each PTE were very low (first 2 steps, < 10%), Cd was mainly associated with the oxidizable phase (likely organic matter), and Cr and Zn were mostly found in residual mineral fraction (likely occluded in non-siliceous mineral phase). The total cumulative concentration of each metal was found to be higher in soil/sediment profiles and ore-processing wastes than in phosphate rocks, indicating a metal enrichment due to mining activities. The aqua regia extraction of representative sediment samples revealed that Cd, Cr, and Zn concentrations were higher than non-polluted sediment standards. In contrast, other elements as Cu, Mn, and Pb essentially arose from natural bedrocks. The Unified BARGE method was applied to assess the risk of ingestion by human beings and wild/domestic animals of contaminated sediment particulate prone to wind erosion and air dispersion in the arid conditions of study area. An higher oral bioaccessibility was found for Cd than Zn and Cr, most concerning in acid gastric phase than in sub-neutral intestinal environment.

Communicating the environmental health risk assessment process: formative evaluation and increasing comprehension through visual design

The environmental health risk assessment process informs clean-up activities at hazardous waste sites. Ensuring this process is accessible and transparent to communities is crucial for environmental health literacy initiatives. The goals of this project were to develop plain language and effective visuals that can be used when communicating the risk assessment process and methods used to predict excess cancer risk(s) due to environmental exposures. In this study, a community factsheet entitled, “Understanding Environmental Health Risk Assessment” was developed and a participatory design and formative evaluation approach was implemented with a set of representative users (n = 11). Community members living in the vicinity of two Arizona hazardous waste sites as well as three public health professionals/researchers were asked to evaluate the functionality and accessibility of the factsheet, particularly the graphics and whether the text was written in plain language. Participant responses revealed the following major findings: 1) form follows function, 2) graphic elements should outweigh text, 3) line of sight and layout is critical to information accessibility, 4) color coding dramatically aids the reader, 5) content should be strategically grouped, 6) concepts per figure should be minimized to ensure comprehension, 7) interactive content is preferred over static content, and 8) communication efforts need to interweave new information with the targeted audience's past and current environmental health understandings to aid in their ability to retain new concepts. Based on participant feedback, new and improved layout decisions, infographics and accompanying text were designed and prepared. This research demonstrates the need and importance of participatory design, information design prototyping, formative evaluation, and a cultural model of risk communication.

Applying ecosystem services for pre-market environmental risk assessments of regulated stressors.

Ecosystem services (ES) are the benefits that people obtain from ecosystems. Investigating the environment through an ES framework has gained wide acceptance in the international scientific community and is applied by policymakers to protect biodiversity and safeguard the sustainability of ecosystems. This approach can enhance the ecological and societal relevance of pre‐market/prospective environmental risk assessments (ERAs) of regulated stressors by: (1) informing the derivation of operational protection goals; (2) enabling the integration of environmental and human health risk assessments; (3) facilitating horizontal integration of policies and regulations; (4) leading to more comprehensive and consistent environmental protection; (5) articulating the utility of, and trade‐offs involved in, environmental decisions; and (6) enhancing the transparency of risk assessment results and the decisions based upon them. Realisation of these advantages will require challenges that impede acceptance of an ES approach to be overcome. Particularly, there is concern that, if biodiversity only matters to the extent that it benefits humans, the intrinsic value of nature is ignored. Moreover, our understanding of linkages among ecological components and the processes that ultimately deliver ES is incomplete, valuing ES is complex, and there is no standard ES lexicon and limited familiarity with the approach. To help overcome these challenges, we encourage: (1) further research to establish biodiversity–ES relationships; (2) the development of approaches that (i) quantitatively translate responses to chemical stressors by organisms and groups of organisms to ES delivery across different spatial and temporal scales, (ii) measure cultural ES and ease their integration into ES valuations, and (iii) appropriately value changes in ES delivery so that trade‐offs among different management options can be assessed; (3) the establishment of a standard ES lexicon; and (4) building capacity in ES science and how to apply ES to ERAs. These development needs should not prevent movement towards implementation of an ES approach in ERAs, as the advantages we perceive of using this approach render it more than worthwhile to tackle those challenges. Society and the environment stand to benefit from this shift in how we conduct the ERA of regulated stressors.

Fluorescence Enhancement of Ethanolic Solution of Nitroarenes and Its Analytical Application.

When ethanolic solutions of 1-nitropyrene (1-NP) and 3-nitrobenzanthorone (3-NBA) were irradiated with intense light, which they absorb, for several minutes, the fluorescence characteristics of the solutions were significantly changed. After such preliminary irradiation, the fluorescence intensity of 1-NP increased immediately by a factor of 104 with a blue shift of 100 nm and that of 3-NBA 700 with a red shift of 10 nm. The findings were applied to high performance liquid chromatography with a fluorescence detector so that the two nitroarenes could be quantitatively analyzed by preliminary irradiation of their solutions before measurements. The calibration curves were linearly drawn over the concentration range from 1.0 × 10-9 to 1.0 × 10-7 M for 1-NP and 1.0 × 10-8 to 1.0 × 10-6 M for 3-NBA and the limits of detection were 2.3 pg for 1-NP and 28 pg for 3-NBA. From the results, fluorescence enhancement was found to be very effective for determining nitroarenes, being practically non-fluorescent and very important in environmental health-risk assessment, easily and sensitively. The mechanism of the fluorescence enhancement of 1-NP and 3-NBA was also discussed.

Occurrence, Distribution, and Potential Sources of Organophosphate Esters in Urban and Rural Surface Water in Shanghai, China.

In this study, the occurrence and distribution patterns of eight organophosphate esters (OPEs) were investigated in urban and rural surface water in a typical cosmopolitan city: Shanghai, China. In addition, concentration levels and removal efficiencies of seven sewage treatment plants were analyzed. The OPEs concentrations detected in urban rivers were significantly higher than those detected in rural rivers. Total OPEs ranged from 185.4 to 321ngL-1 in rural surface water and from 340 to 1688.7ngL-1 in urban, with an average of 221.8ngL-1 and 850.2ngL-1, respectively. Compared with other studies published in the world, the OPEs contamination in surface river water in Shanghai was at a moderate level. Furthermore, the potential sources of OPEs in urban surface water were investigated, and the results indicated that OPEs in urban surface water mainly came from three potential sources. In rural surface water, the OPE concentrations were uniformly distributed, so OPEs in rural surface water may came from nonpoint source pollution. Last, a preliminary environmental risk assessment and health risk assessment were conducted. The results showed low environmental risks at all sampling sites (except for sampling point R7: medium risk for algae) for the three aquatic organisms (algae, daphnia, and fish). Health risk assessment indicated a noncarcinogenic risk for diverse human groups for ƩOPEs.

The Lead Exposure Risk Due to Wells Water Consumption in Code Riverside Community, Yogyakarta City

The environmental conditions of Code River were strongly influenced by anthropogenic activities that include industry, hospitals, domestic, and agriculture. The contamination status on the Code River according to BLH Yogyakarta reported in 2014 was heavily polluted based on STORET (≤-31). The riverside community were misusing the river for final disposal site, potentially contaminating it with lead (Pb). Local communities were potentially exposed to Pb toxicity through well water consumption. An Environmental Health Risk Assessment (EHRA) study of ingestion exposure of heavy metals was never conducted in the Code Riverside, making it interesting for further studies. The study aimed to determine human health risks of consumption of well water containing Pb in Code Riverside, Yogyakarta City using an observational design with an Environmental Health Risk Assessment approach. There were 9 environmental samples and 47 respondents selected based on certain criteria. Data was collected through environmental inspection and human health assessment, interviews and anthropometric data measurement of respondents. Data was analyzed by univariate (frequency distribution) and EHRA methods. The result showed that the noncarcinogenic risk level of Pb due to well water consumption from majority of research sites have RQ value (Risk Quotient) &gt; 1, which means high potential risk to human health.

Distinctive fingerprints of genotoxicity induced by As, Cr, Cd, and Ni in a freshwater fish.

Genotoxicity of three toxic elements (chromium, cadmium, nickel) and a metalloid (arsenic) has been studied in a freshwater fish, Channa punctatus using micronuclei (MN) test, comet assay, and erythrocyte nuclear alterations (ENAs) as fingerprints of genotoxicity. These tests yielded different results suggesting involvement of different mechanisms for their genotoxicity. While highest frequency of blebbed nuclei was observed in chromium-treated fish (6.5 ± 0.76), lowest was observed in cadmium-treated fish (4.0 ± 1.0). Maximum number of notched nuclei was recorded in arsenic-treated fish (5.5 ± 1.15) whereas highest numbers of lobed nuclei were found in cadmium-treated fish (4.5 ± 0.13). These differences might be attributed to selective bioaccumulation and chemodynamics of each element. Other parameters used to determine genotoxicity viz.: lipid peroxidation and DNA damage also suggested different mechanisms of their genotoxicity. It is suggested that an integrative approach, using a battery of tests for determining genotoxicity, should be made while making environmental health risk assessment and ecotoxicological studies of these toxic elements.

Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks

Traffic-related air pollution (TRAP) is a complex mixture of compounds that contributes to the pathogenesis of many diseases including several types of cancer, pulmonary, cardiovascular and neurodegenerative diseases, and more recently also diabetes mellitus. In search of an early diagnostic biomarker for improved environmental health risk assessment, recent human studies have shown that certain extracellular miRNAs are altered upon exposure to TRAP. Here, we present a global circulating miRNA analysis in a human population exposed to different levels of TRAP. The cross-over study, with sampling taking place during resting and physical activity in two different exposure scenarios, included for each subject personal exposure measurements of PM10,PM2.5, NO, NO2, CO, CO2, BC and UFP. Next-generation sequencing technology was used to identify global circulating miRNA levels across all subjects. We identified 8 miRNAs to be associated with the mixture of TRAP and 27 miRNAs that were associated with the individual pollutants NO, NO2, CO, CO2, BC and UFP. We did not find significant associations between miRNA levels and PM10 or PM2.5. Integrated network analysis revealed that these circulating miRNAs are potentially involved in processes that are implicated in the development of air pollution-induced diseases. Altogether, this study demonstrates that signatures consisting of circulating miRNAs present a potential novel biomarker to be used in health risk assessment.

Household Waste Management For The Achievement Of SDGs In Bulak Surabaya

The purpose of this study was to determine the conduct or description about household waste management in the district of Bulak Surabaya by using studies EHRA (Environmental Health Risk Assessment) where a study of participation in the District / City to understand the conditions of sanitation facilities and hygiene as well as societal attitudes on a scale house stairs. This research was conducted by field observations and interview. District activities and respondents are randomly assigned study area. Based upon the results of research studies EHRA in District of Bulak Surabaya, there are 200 respondents, only a small proportion of respondents who perform household waste management around 19.5%, while those who are not managing 80.5% achievement SDGs taken from point 6 "Water and sanitation" where trash organic collected in TPS (temporary disposal sites) can be treated with an organic fertilizer made so that the waste that goes to landfill (landfill) was reduced by 40 tons a day.

Environmental Health Risk Assessment of Phthalic Acid Esters in Drinking Water Source Catchments of South China

Environmental Health Risk Assessment of Phthalic Acid Esters in Drinking Water Source Catchments of South China

Geochemical baseline establishment, environmental impact and health risk assessment of vanadium in lake sediments, China

Lakes are essential water resources in China and their water quality is vital to the sustainability. However, the geochemical processes of trace elements, especially those of seldom-monitored trace elements, have not been adequately studied. Here, the regional geochemical baseline (RGB) of vanadium (V) was established using cumulative frequency and normalization methods. Then, the RGB was applied to quantitatively calculate the anthropogenic contribution rate in sediments of the Poyang Lake (PYL), which is the largest freshwater lake in China. The pollution level and ecological risk of V were evaluated using the geoaccumulation index (Igeo) and potential ecological risk index (EI) with respect to three different reference values, namely local soil background values (BV), the RGB, and the median value of V concentrations. The health risk of V accumulation in residents through fish consumption during sediment resuspension was assessed by combining the environmental impact assessment model and health risk assessment model. The mean concentration of V in PYL sediments was 94.37 mg/kg (33.80–148.53 mg/kg), which was slightly higher than the levels in stream sediments in China, but lower than the local BV. The calculated RGB was slightly higher than the average V content in PYL sediments, but similar to the local BV. The average anthropogenic contribution rate was calculated as 11.48%, demonstrating low anthropogenic influence. Moreover, the result of Igeo and EI showed that V in PYL sediments was uncontaminated and posed a low ecological risk. In addition, based on the calculation by the two models, the human health risk result (target hazard quotient <1) indicated that the average human health risk from fish consumption due to sediment resuspension was negligible.

Health risk assessment of engine exhaust emissions within Australian ports: a case study of Port of Brisbane

Emissions from ocean-going vessels present a significant health risk to populations surrounding ports and damage the environment. Emissions from ships using heavy fuel oil include substantial amounts of sulphur dioxide, nitrogen oxides, and particulate matter. In order to assess the risk of these emissions, a complete methodology has been developed, based on the Australian Environmental Health Risk Assessment Framework. The method includes a detailed inventory of in-port and at-sea emissions using an activity-based approach applying downwash and near-field areas from first principles equations as well as the air-shed regions from CALPUFF dispersion modeling results for Port of Brisbane in 2013. The final risk values are validated against national and European guidelines. Various health impact assessments, as well as carcinogenic and ecological effects, are discussed in depth. This study offers a significant contribution to developing a baseline measurement of the current state of risk from emissions of the ocean-going vessels visiting the port, and suggests that, given the expected development of many Australian ports in the near future, the need for continual monitoring of shipping emissions is an essential and necessary area of research.