Environmental Health Assessment Research Articles

Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells

Environmental pollution often releases multiple contaminants resulting in as yet largely uncharacterized additive toxicities. Cadmium (Cd) is a widespread pollutant that induces nephrotoxicity in animal models and humans. However, the combined effect of Cd in causing nephrotoxicity with 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), a typical congener of polybrominated diphenyl ethers (PBDEs), has not been evaluated and mechanisms are not completely clear. Here, we applied transcriptome sequencing analysis to investigate the combined toxicity of Cd and BDE-47 in the renal tubular epithelial cell lines HKCs. Cd or BDE-47 exposure decreased cell viability in a dose-dependent manner, and exhibited cell swelling and rounding similar to necrosis, which was exacerbated by co-exposure. Transcriptomic analysis revealed 2191, 1331 and 3787 differentially-expressed genes following treatment with Cd, BDE-47 and co-exposure, respectively. Interestingly, functional annotation and enrichment analyses showed involvement of pathways for oxidative stress, NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and inflammatory cell death for all three treatments. Examination of indices of mitochondrial function and oxidative stress in HKC cells showed that the levels of reactive oxygen species (ROS), malondialdehyde (MDA) and intracellular calcium ion concentration [Ca2+]i were elevated, while superoxide dismutase (SOD) and mitochondrial membrane potential (MMP) were decreased. The ratio of apoptotic and necrotic cells and intracellular lactate dehydrogenase (LDH) release were increased by Cd or BDE-47 exposure, and was aggravated by co-exposure, and was attenuated by ROS scavenger N-Acetyl-L-cysteine (NAC). NLRP3 inflammasome and pyroptosis pathway-related genes of NLRP3, adaptor molecule apoptosis-associated speck-like protein (ASC), caspase-1, interleukin-18 (IL-18) and IL-1β were elevated, while gasdermin D (GSDMD) was down-regulated, and protein levels of NLRP3, cleaved caspase-1 and cleaved GSDMD were increased, most of which were relieved by NAC. Our data demonstrate that exposure to Cd and BDE-47 induces mitochondrial dysfunction and triggers NLRP3 inflammasome and GSDMD-dependent pyroptosis leading to nephrotoxicity, and co-exposure exacerbates this effect, which could be attenuated by inhibiting ROS. This study provides a further mechanistic understanding of kidney damage, and co-exposure impact is worthy of concern and should be considered to improve the accuracy of environmental health assessment.

Environmental monitoring and health assessment in an industrial town in central India: A cross-sectional study protocol.

Textile industry has been widely implicated in environmental pollution. The health effects of residing near manufacturing industries are not well documented in India, especially in central India. Hence, a cross-sectional environmental monitoring and health assessment study was initiated as per directions of the local authorities. Comprehensive exposure data about the concentrations of relevant pollutants in the ambient air and ground water samples in the study area will be collected over one year. Using stratified random sampling, 3003 apparently healthy adults will be selected from the study area. Sociodemographic and anthropometric information, relevant medical and family history, and investigations including spirometry, electrocardiogram, neurobehavioral tests, and laboratory investigations (complete blood count, lipid profile and random blood glucose) will be conducted. Finally Iodine azide test and heavy metal level detection in urine and blood samples respectively will be conducted in a subset of selected participants to assess individual pollution exposure. Ethics approval has been obtained from the Institutional Ethics Committee of the National Institute for Research in Environmental Health (No: NIREH/IEC-7-II/1027, dated 07/01/2021). This manuscript describes the protocol for a multi-disciplinary study that aims to conduct environmental monitoring and health assessment in residential areas near viscose rayon and associated chemical manufacturing industries. Although India is the second largest manufacturer of rayon, next only to China, and viscose rayon manufacturing has been documented to be a source of multiple toxic pollutants, there is a lack of comprehensive information about the health effects of residing near such manufacturing units in India. Therefore implementing this study protocol will aid in filling in this knowledge gap.

Mutagenicity and carcinogenicity of combustion emissions are impacted more by combustor technology than by fuel composition: A brief review.

Studies during the past 50 years have characterized the carcinogenicity and mutagenicity of extractable organic material (EOM) of particulate matter (PM) in ambient air and from combustion emissions. We have summarized conclusions from these studies and present data supporting those conclusions for 50 combustion emissions, including carcinogenic potencies on mouse skin (papillomas/mouse/mg EOM), mutagenic potencies (revertants/μg EOM) in the Salmonella (Ames) mutagenicity assay, and mutagenicity emission factors (revertants/kg fuel or revertants/MJthermal) in Salmonella. Mutagenic potencies of EOM from PM in ambient air and combustion emissions span 1–2 orders of magnitude, respectively. In contrast, the revertants/m3 span >5 orders of magnitude due to variable PM concentrations in ambient air. Carcinogenic potencies of EOM from combustion emissions on mouse skin and EOM‐associated human lung cancer risk from those emissions both span ~3 orders of magnitude and are highly associated. The ubiquitous presence of polycyclic aromatic hydrocarbons (PAHs), nitroarenes, and aromatic amines results in mutagenic and carcinogenic potencies of PM that span only 1–3 orders of magnitude; most PM induces primarily G to T mutations. Mutagenicity emission factors of combustion emissions span 3–5 orders of magnitude and correlate with PAH emission factors (r > 0.9). Mutagenicity emission factors were largely a function of how material was burned (highly efficient modern combustors versus open burning) rather than what materials were burned. Combustion systems that minimize kinetic and mass‐transfer limitations and promote complete oxidation also minimize the mutagenicity of their emissions. This fundamental engineering principle can inform environmental and public health assessments of combustion emissions.

Integrating Environment and Aging Research: Opportunities for Synergy and Acceleration.

Despite significant overlaps in mission, the fields of environmental health sciences and aging biology are just beginning to intersect. It is increasingly clear that genetics alone does not predict an individual’s neurological aging and sensitivity to disease. Accordingly, aging neuroscience is a growing area of mutual interest within environmental health sciences. The impetus for this review came from a workshop hosted by the National Academies of Sciences, Engineering, and Medicine in June of 2020, which focused on integrating the science of aging and environmental health research. It is critical to bridge disciplines with multidisciplinary collaborations across toxicology, comparative biology, epidemiology to understand the impacts of environmental toxicant exposures and age-related outcomes. This scoping review aims to highlight overlaps and gaps in existing knowledge and identify essential research initiatives. It begins with an overview of aging biology and biomarkers, followed by examples of synergy with environmental health sciences. New areas for synergistic research and policy development are also discussed. Technological advances including next-generation sequencing and other-omics tools now offer new opportunities, including exposomic research, to integrate aging biomarkers into environmental health assessments and bridge disciplinary gaps. This is necessary to advance a more complete mechanistic understanding of how life-time exposures to toxicants and other physical and social stressors alter biological aging. New cumulative risk frameworks in environmental health sciences acknowledge that exposures and other external stressors can accumulate across the life course and the advancement of new biomarkers of exposure and response grounded in aging biology can support increased understanding of population vulnerability. Identifying the role of environmental stressors, broadly defined, on aging biology and neuroscience can similarly advance opportunities for intervention and translational research. Several areas of growing research interest include expanding exposomics and use of multi-omics, the microbiome as a mediator of environmental stressors, toxicant mixtures and neurobiology, and the role of structural and historical marginalization and racism in shaping persistent disparities in population aging and outcomes. Integrated foundational and translational aging biology research in environmental health sciences is needed to improve policy, reduce disparities, and enhance the quality of life for older individuals.

Strategic Assessment of Neighbourhood Environmental Impacts on Mental Health in the Lisbon Region (Portugal): A Strategic Focus and Assessment Framework at the Local Level

Scientific evidence shows that each place/environment generates specific conditions with associated impacts on the mental health and well-being of the population. A holistic, multilevel and integrated environmental approach to mental health enhances the understanding of this phenomena, supporting the local decision-making processes to improve spatial planning of neighbourhood environments. The aim of this study is to develop a strategic assessment framework, based on four municipalities in the Lisbon Region (Portugal), that explores policy and planning initiatives capable of generating favourable neighbourhood environmental conditions for mental health while also detecting risks. Using baseline results of significant statistical associations between individuals’ perceptions of their neighbourhood environment and their mental health in the Lisbon Region, a Strategic Focus on Environmental and Mental Health Assessment framework (SEmHA) was built, by applying the methodology “Strategic Thinking for Sustainability” in Strategic Environmental Assessment, developed by Partidário in 2012. Taking into account the promotion of the population’s mental health, four critical decision factors of neighbourhood environments were identified: (1) public space quality (e.g., improving sense of place), (2) physical environment quality (e.g., low levels of noise exposure), (3) professional qualification and creation of economic activities (e.g., attracting new economic activities), and (4) services and facilities (e.g., improving access to health and education services). The proposed strategic focus and assessment framework contributes to ensuring that interventions in neighbourhood environments truly achieve community mental health benefits and reduce inequalities, thus helping policy makers to assess impacts at the local level.

Bacterial Indicators Are Ubiquitous Members of Pelagic Microbiome in Anthropogenically Impacted Coastal Ecosystem.

Coastal zones are exposed to various anthropogenic impacts, such as different types of wastewater pollution, e.g., treated wastewater discharges, leakage from sewage systems, and agricultural and urban runoff. These various inputs can introduce allochthonous organic matter and microbes, including pathogens, into the coastal marine environment. The presence of fecal bacterial indicators in the coastal environment is usually monitored using traditional culture-based methods that, however, fail to detect their uncultured representatives. We have conducted a year-around in situ survey of the pelagic microbiome of the dynamic coastal ecosystem, subjected to different anthropogenic pressures to depict the seasonal and spatial dynamics of traditional and alternative fecal bacterial indicators. To provide an insight into the environmental conditions under which bacterial indicators thrive, a suite of environmental factors and bacterial community dynamics were analyzed concurrently. Analyses of 16S rRNA amplicon sequences revealed that the coastal microbiome was primarily structured by seasonal changes regardless of the distance from the wastewater pollution sources. On the other hand, fecal bacterial indicators were not affected by seasons and accounted for up to 34% of the sequence proportion for a given sample. Even more so, traditional fecal indicator bacteria (Enterobacteriaceae) and alternative wastewater-associated bacteria (Lachnospiraceae, Ruminococcaceae, Arcobacteraceae, Pseudomonadaceae and Vibrionaceae) were part of the core coastal microbiome, i.e., present at all sampling stations. Microbial source tracking and Lagrangian particle tracking, which we employed to assess the potential pollution source, revealed the importance of riverine water as a vector for transmission of allochthonous microbes into the marine system. Further phylogenetic analysis showed that the Arcobacteraceae in our data set was affiliated with the pathogenic Arcobacter cryaerophilus, suggesting that a potential exposure risk for bacterial pathogens in anthropogenically impacted coastal zones remains. We emphasize that molecular analyses combined with statistical and oceanographic models may provide new insights for environmental health assessment and reveal the potential source and presence of microbial indicators, which are otherwise overlooked by a cultivation approach.

Electronic Waste Reduction Through Devices and Printed Circuit Boards Designed for Circularity

The development of printed circuit boards (PCBs) has so far followed a traditional linear economy value chain, leading to high volumes of waste production and loss of value at the end-of-life. Consequentially, the electronics industry requires a transition to more sustainable practices. This review article presents an overview of the potential solutions and new opportunities that may arise from the greater use of emerging sustainable materials and resource-efficient manufacturing. A brief contextual summary about how the international management of waste PCBs (WPCBs) and legalization have evolved over the past 20 years is presented along with a review of the existing materials used in PCBs. The environmental and human health assessments of these materials relative to their usage with PCBs are also explained. This enables the identification of which ecofriendly materials and new technologies will be needed to improve the sustainability of the industry. Following this, a comprehensive analysis of existing WPCB processing is presented. Finally, a detailed review of potential solutions is provided, which has been partitioned by the use of emerging sustainable materials and resource-efficient manufacturing. It is hoped that this discussion will transform existing manufacturing facilities and inform policies, which currently focus on waste management, toward waste reduction and zero waste.

Assessment of marine environmental health of Yantai offshore based on the new "dual-core" framework.

The health of marine ecological environment is a key factor restricting the development of marine economy. It is important to scientifically and systematically assess the overall ecological health of coastal marine. Based on the newly constructed "dual-core" assessment framework, which takes the state of marine ecosystem as the inner-core and the human socio-economic index as the outer-core, the health status of Yantai coastal marine environment was comprehensively assessed with the survey data from 2008 to 2016. The results showed that the inner-core elements for Yantai coastal area were mainly rated as "excellent" or "good" level. Generally, the sediment quality was the best, while water environment quality was slightly poor. The status of biological community was the core factor determining final rating. For the outer-core assessment, Yantai coastal areas scored 0.98, based on the output value of marine industrial and area of marine reserves. The final "dual-core" assessment result for Yantai offshore area was "excellent/good + 0.98", which indicated that the healthy status of ecological environment of Yantai offshore area was still good, in spite of high degree of development and utilization, but some areas had begun to deteriorate, which needed to be paid special attention in the further developing of marine industry. Our results following the "dual core" framework could provide guidance for the management and decision-making related marine resources development and environmental protection, and is of great significance to realize sustainable utilization of marine resources and environment.

Fine-tune of lignin properties by its fractionation with a sequential organic solvent extraction

In this work, different lignins were obtained from two different extraction methods (kraft and organosolv) but from the same raw material (Eucalyptus globulus sp.). They were subsequently fractionated to determine the differences of each extraction method and their corresponding physicochemical properties found in fractionation sequence and obtained fractions. The goal of the fractionation was to obtain lignin fractions with narrower molecular weight distribution and lower polydispersity index (PI). The solvent sequence was designed based on the environmental friendly properties, health and safety assessments of the selected organic solvents: (methanol (MeOH), ethanol (EtOH), propan-2-one (DMK), ethyl acetate (EtOAc), propan-1-ol (nPrOH), propan-2-ol (iPrOH), butan-2-one (MEK), and butan-1-ol (tBuOH)). The different fractions obtained were characterised to determine their chemical structure by several analytical techniques, such as Fourier Transformed Infrared Spectroscopy (FTIR), Ultraviolet (UV), Phosphorus-31 Nuclear Magnetic Resonance (31P NMR), Pyrolysis–Gas Chromatography/Mass Spectrometry (Py-GC/MS), Thermogravimetric analysis (TGA), and Differential scanning calorimetry (DSC). In addition, Gel Permeation Chromatography (GPC) was used to obtain the molecular weight distribution. This study showed an effective method for obtaining homogeneous lignins with specific structures and properties depending on the solvent and molecular weight attained. Moreover, the method designed was found to be effective regardless of the lignin extraction process employed; besides, various lignin fractions were obtained which were different from each other, having specific target applications depending on their structure and chemical properties, ranging from small molecules with abundant reactive sites to act as active materials or copolymer reagents for many applications, to larger and more inactive molecules with higher thermal resistivity.

Evaluation of heavy metal (Cu, Pb, Zn) distribution in base metal mining area at Sangkaropi: implication for land use planning

Settling-pond treatment systems have been applied in the base-metal mining area at Sangkaropi, South Sulawesi, Indonesia, before being discharged into the Koyan River through the agriculture area. This study aims to conduct a valuation of pollutant Pb, Cu and Zn in areas impacted by base-metal mining in sediment materials as a sensitive indicator for monitoring contaminants in the aquatic environment. Sediment sampling location, the first is in the upstream before the mining location, the second is located in the mining area to settling pond, and the third is in the area after settling-pond to the agriculture area. The concentrations of heavy metal were analyzed using uses AAS method. The assessment is performed based on the value of contamination degree, enrichment of heavy metal pollutant and ecological risk. The arrangement of the average frequency of heavy metal concentrations is Pb>Cu>Zn, which Cf and I-geo values have the almost same behavior. All metal in the upstream and agriculture site is classified as a low category, the Cu on the second and third sites is moderate. The assessment results from this study represent that Pb has a considerable ecological risk category value. However, polluted-Cu are categorized moderately need to be cautious, because metal enrichment comes from mineralization bedrock in the river. Therefore, the result of this study shows that geologic data, especially mineralized bedrocks associated the heavy metal concentration, should be taken into consideration in land-use planning policy in areas that have been impacted by mining and in the assessment of environmental health impacts.

Evidence of micro-evolution in Crocidura russula from two abandoned heavy metal mines: potential use of Cytb, CYP1A1, and p53 as gene biomarkers

Heavy metals accumulated in the environment due to the mining industry may impact on the health of exposed wild animals with consequences at the population level via survival and selection of the most resistant individuals. The detection and quantification of shifts in gene frequencies or in the genetic structure in populations inhabiting polluted sites may be used as early indicators of environmental stress and reveal potential 'candidate gene biomarkers' for environmental health assessment. We had previously observed that specimens of the Greater white-toothed shrew (Crocidura russula) from two heavy metal mines in Southern Portugal (the Aljustrel and the Preguiça mines) carried physiological alterations compared to shrews from an unpolluted site. Here, we further investigated whether these populations showed genetic differences in genes relevant for physiological homeostasis and/or that are associated with pathways altered in animals living under chronic exposure to pollution, and which could be used as biomarkers. We analysed the mitochondrial cytochrome b (Cytb) gene and intronic and/or exonic regions of four nuclear genes: CYP1A1, LCAT, PRPF31, and p53. We observed (1) population differences in allele frequencies, types of variation, and diversity parameters in the Cytb, CYP1A1, and p53 genes; (2) purifying selection of Cytb in the mine populations; (3) genetic differentiation of the two mine populations from the reference by the p53 gene. Adding to our previous observations with Mus spretus, we provide unequivocal evidence of a population effect exerted by the contaminated environment of the mines on the local species of small mammals.

Environmental biomonitoring using different biomarkers and their contribution in aquatic environmental research

In an era where innumerable biological and synthetic compounds are perpetually introduced into the market every day in various forms, such as pharmaceuticals, cosmetics, nutraceuticals, fertilizers, pesticides, and nanoparticles, to serve multiple purposes, there is a need to develop rapid screening methods to evaluate their biosafety. Wide array of biomarkers used to demonstrate exposure to and effect of environmental contamination. In order to assess exposure to or effect of environmental pollutant on aquatic environment the following suite of fish biomarkers may be examined, oxidative stress parameters, hematological parameters, immunological parameters, genotoxic parameters and histology. The text explores the latest knowledge and thinking on these very important approaches for the assessment of environmental health, management and conservation. This review focuses on measurement of the genotoxic potential of chemicals in aquatic organism at different level of biological organization under field and laboratory conditions by using comet assay, micronucleus assay, polychromatic erythrocyte count.

Landscape Dynamics Improved Recreation Service of the Three Gorges Reservoir Area, China.

Spatio-temporal variations of recreation service not only could help to understand the impact of cultural services on human well-being but also provides theoretical and technical support for regional landscape management. However, previous studies have avoided deeply quantifying and analyzing it or have simply focused on assessing recreational service at a single period in time. In this study, we used the InVEST model to evaluate the spatio-temporal variations of recreation service in the Three Gorges Reservoir Area and demonstrated the impact of recreation service on landscape dynamics. The results demonstrated that recreation service increased significantly and presented a significant spatial heterogeneity. Although afforestation and urban expansion both could significantly increase recreation service, the recreation service proxy of the non-vegetation landscape is far higher than that of the vegetation landscape. This finding indicated that human landscape is more attractive to tourists than the natural landscape, so we recommend to strengthen the infrastructure construction for enhancing the accessibility of natural landscapes. Moreover, we propose other constructive suggestions and landscape-design solutions for promoting recreation service. This study shifted the static environmental health assessment to the analysis of recreation service dynamics, bridging the regulatory mechanisms of ecosystem services involved in cultural services.

Marine Water Quality at Diego Garcia: A Preliminary Study of Pollution Levels in Coastal and Lagoon Waters

Diego Garcia is the largest atoll within the Chagos Archipelago in the Indian Ocean. Since the 1960s it has been a military base, populated only by military and support personnel. Infrastructure includes sewage treatment works, a waste disposal facility and an airbase. Lagoon use includes boating and large vessel anchorage. Current pollution levels by inorganic nutrients and other contaminants are unknown. A field study was undertaken in March 2019 to obtain baseline information on key environmental parameters and pollutants for assessing the state of marine water quality. Outside the atoll, three stations were sampled where human impacts were likely to be lowest (two off the north coast, considered as ‘near-pristine’; one on the east coast); one station was sampled in the lagoon mouth; 10 stations were sampled downstream from two sewage outflows. Inside the lagoon, 10 stations were sampled at near-shore sites likely to be directly impacted by activities such as boating and waste management; six stations were sampled in the central or eastern lagoon. In situ sensors were used to estimate temperature, salinity, chlorophyll (as fluorescence) and dissolved oxygen. Discrete water samples were analyzed for nutrients, chemical contaminants, heavy metals and fecal indicator bacteria. Sea surface temperatures were highest (29.5–35 °C) inside the lagoon; salinities were generally higher (> 34.1) outside the lagoon (vs 33.8–34.1 inside). Surface nutrient concentrations at near-pristine stations were undetectable for nitrate and phosphate and averaged 1.39 μM for dissolved inorganic nitrogen (DIN) and 1.73 μM for silicate. Concentrations were higher at most other stations (maximum 5.7 μM DIN, 0.38 μM phosphate, and 9.93 μM silicate), with ammonium contributing most to DIN. In the lagoon, chlorophyll concentrations were relatively low (0.3 – 0.6 μg chl l–1) near the surface and higher (max 0.9 μg chl l–1) at depth. Results suggested low levels of pollution overall. However, levels of nutrients, oxygen deficiency, chemical contaminants (e.g., solvents and DEET) and heavy metals (cadmium, nickel, zinc and copper) at some sites inside the lagoon are a concern due to slow flushing rates and will be used to inform future monitoring and assessment of environmental health at Diego Garcia.

Human health risk of mercury in street dust: A case study of children in the vicinity of compact fluorescence lamp factory, Hanoi, Vietnam.

Urban dust has been contaminated with toxic heavy metals from various diffused sources. On August 28, 2019, the compact fluorescence lamp (CFL) factory that generates light for Rang Dong Light Source and Vacuum Flask in Hanoi City in Vietnam was accidentally fired. The assessment for Hg contamination and its human health impact 2 months after the incident was conducted in autumn 2019. The heavy Hg pollution is still found near CFL. Additionally, localized Hg pollution by air and wind direction was identified at sites in the northeast direction from CFL. Namely, in the area located downstream of the southwest monsoon wind, Hg had a trend higher than other directions. The hazard quotient (HQ) and the hazard index (HI) were evaluated by four routes of Hg exposure pathways. The HI values for children and adults in the most polluted site (Site 15) were 0.968 and 0.468, respectively. This meant that children who lived around this site and commuted to schools were the most at risk regarding the potential adverse health effects of Hg in street dust around the polluted areas. This study also showed that Hg levels were affected by wind direction and that the higher Hg levels in the most polluted sites resulted from the wind flow to the sites. This study revealed that street dust may be a useful tool for the assessment of human and environmental health.

Joint development of cultural heritage protection and tourism: the case of Mount Lushan cultural landscape heritage site

The joint development of cultural heritage protection and tourism is an essential part of sustainable heritage tourism. Mount Lushan in China is such a site which in the past has had shortcomings in heritage protection and heritage tourism marketing. The present research addresses this issue by using digital technologies such as oblique aerial photography, 3D laser scanning technology, and 360 degrees panorama technology to digitize the Mount Lushan cultural landscape heritage site, integrating all elements to create a virtual tourism subsystem. It provides users with a virtual experience of cultural landscape heritage tourism and promotes cultural landscape tourism marketing. In addition, tourist flow and environmental subsystems were built through the integration of Internet of Things (IoT) technology and analytical models. The tourist flow subsystem can help managers to regulate tourist flow according to the tourist carrying capacity threshold. Managers can also conduct environmental health assessment and management through the "pressure-state-response" model provided by the environmental subsystem. Finally, a comprehensive platform was developed based on the system concept, which integrated the three subsystems and their functions, and developed different versions to provide a visual platform for tourists and managers. This study provides a new model for the joint development of cultural heritage protection and tourism activities.

WITHDRAWN: Usage of deep learning in environmental health risk assessment.

Ahead of Print article withdrawn by publisher.

A new computer-based index for swimming pools' environmental health assessment in big data environment by consensus-based fuzzy group decision-making models.

Swimming pools are popularly used for sport and recreational purposes worldwide. These places influence swimmers' health as they are considered public places. This study attempted to introduce a process mining framework which analyzes the environmental health status in swimming pools. In this context, a new numerical index namely Swimming Pool Environmental Health Index (SPEHI) was developed through which, big data extracted from checklists of environmental health inspection of swimming pools were analyzed in fuzzy environment. The methodology comprises MCDM (Multi- Criteria Decision-Making) approach including fuzzy TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) and fuzzy OWA (Ordered Weighting Average). The performance of this index was evaluated through an applied example on 12 swimming pools in Shiraz, Iran that was run for a three-year sequence from 2015 to 2017. Among 30 evaluation criteria used in this index, the greatest (0.61) and lowest (0.35) group weights were dedicated to "Residual chlorine biological water quality" and "existence of drinking water facilities", respectively. For the study area, SPEHI showed a wide range of environmental health conditions between 37.8 (Relatively good) to 98.19 (Excellent). The extended index could shrink swimming pool's big data to concise values which are interpretable for health experts and managers of sport sector. It helps figuring out the trends of hygiene conditions in a swimming pool over the time and easy access to compare a city's swimming pools as well. The methodology is flexible in structure and thus, it could be applied for other sporting places.

Indoor Environmental Health Assessment in Eco-Building and Its Case Study

It is necessary to consider all aspects of environmental factors when assessing the health impact of an eco-building environment on its occupants. However, the multi-criteria and imprecise nature of the indoor-environment in the eco-buildings has caused difficulties in quantifying the indoor environmental pollution level. This paper describes the optimal classification and priority weight methods, which are particularly useful for assessing the indoor environmental quality (IEQ) of an eco-building to demonstrate its innovative applications. The analytic hierarchy process (AHP) was used to set up the strategic decision-making evaluation system for computing the indoor environment index (IEI) risk ranking of eco-buildings. Combined with this, a Microsoft Delphi-based IEQ intelligent forecasting software simulations package was developed, and the innovative application of indoor environmental comprehensive assessment was verified by a case study in Shanghai. The evaluation result was analyzed by the priority weight methods and the AHP decision-making system noted above. This health assessment method and system provides an innovative way for the indoor environment risk evaluation of eco-buildings and is helpful to standardize the local building market.

Methodology for environmental health assessment of adaptive response to professional activity factors as part of health risk assessment

Introduction. The article presents the findings of a study of the adaptive responses of working people depending on their professional activity nature. The purpose of the study is to evaluate the adaptive response of working people exposed to harmful and dangerous factors. Material and methods. The research involved 225 people, including 157 cases exposed to different hazards and dangers: Chernobyl nuclear power plant disaster relief workers (their average age was 59.2 ± 2.2 years (M ± m)); servicemen working with rocket fuels (their average age was 30.6 ± 1.3 years (M ± m)); and service members participated in combat operations (their average age was 32.0 ± 0.8 years (M ± m)). A set of standard methods was used to assess their cardiorespiratory system’s functional state, biological age, activity levels in different organs, and adaptive abilities. Results. The study has made it possible to describe distribution in terms of ANS response, biological age, adaptive potential, and their correlation. The relief workers showed a medium inverse correlation between adaptive potential and ANS response type (r = -0.308; p = 0.153) and a significant medium positive correlation between adaptive potential and biological age (r = 0.690; p < 0.001). The servicemen working with rocket fuels showed a high medium positive correlation (r = 0.726; p = 0.001) and a significant medium positive correlation (r = 0.658; p < 0.004) between adaptive potential and ANS response type and biological age, respectively. The servicemen who had participated in combat operations showed weak inverse correlation (r = -0.139; p = 0.155) and medium positive correlation (r = 0.683; p = 0.005) in the first and second case, respectively. Conclusion. The biological age, individual aging rate, ANS response, and potential adaptive performance can be used as criteria for assessing health risks for working people exposed to different hazards and dangers and determining groups of people who need case follow-up.