Photovoltaic development has played a crucial role in mitigating the energy crisis and addressing global climate change. However, it has also had significant impacts on the ecological environment. To ensure the sustainable growth of the photovoltaic industry, it is essential to establish an indicator system to assess the ecological and environmental effects of photovoltaic development. This study utilizes the Driving-Pressure–Status–Impact-Response (DPSIR) framework to create an indicator system for evaluating the ecological and environmental effects of desert photovoltaic development. The study evaluates the ecological and environmental effects at the on-site (WPS), transitional zone (TPS), and off-site (OPS) areas of the Qinghai Gonghe Photovoltaic Park in China. The entropy weight method was utilized to calculate indicator weights, while the evaluation model and indicators were transformed uniformly to obtain standardized scores for ecological and environmental effects. and conducting a thorough analysis of the distribution characteristics and factors influencing the evaluation indicators’ scores. Overall, the large-scale development of desert photovoltaics in Gonghe County has had a positive impact on the ecological environment. The WPS had better ecological and environmental conditions than did the TPS and OPS, and the ecological and environmental evaluation levels of the WPS were categorized as “general” (0.439), while the ecological and environmental effect evaluation levels of the TPS (0.286) and OPS (0.28) were both “poor”, indicating significant room for improvement. Moreover, all indicators in the scheme layer, which are used to evaluate ecological and environmental quality, yielded higher scores for the WPS than for the TPS and OPS, demonstrating that photovoltaic development has a positive effect on desert area ecology and the environment.