Environmental Adaptation Research Articles

Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death.

Cells must adapt to environmental changes to maintain homeostasis. One of the most striking environmental adaptations is entry into hibernation during which core body temperature can decrease from 37°C to as low at 4°C. How mammalian cells, which evolved to optimally function within a narrow range of temperatures, adapt to this profound decrease in temperature remains poorly understood. In this study, we conducted the first genome-scale CRISPR-Cas9 screen in cells derived from Syrian hamster, a facultative hibernator, as well as human cells to investigate the genetic basis of cold tolerance in a hibernator and a non-hibernator in an unbiased manner. Both screens independently revealed glutathione peroxidase 4 (GPX4), a selenium-containing enzyme, and associated proteins as critical for cold tolerance. We utilized genetic and pharmacological approaches to demonstrate that GPX4 is active in the cold and its catalytic activity is required for cold tolerance. Furthermore, we show that the role of GPX4 as a suppressor of cold-induced cell death extends across hibernating species, including 13-lined ground squirrels and greater horseshoe bats, highlighting the evolutionary conservation of this mechanism of cold tolerance. This study identifies GPX4 as a central modulator of mammalian cold tolerance and advances our understanding of the evolved mechanisms by which cells mitigate cold-associated damage-one of the most common challenges faced by cells and organisms in nature.

Functional and evolutionary analysis of key enzymes triacylglycerol lipase, glycogen hydrolases in the glycerol and glucose biosynthesis pathway and cellular chaperones for freeze-tolerance of the Rice stem borer, Chilo suppressalis

Freeze-tolerance is an important physiological trait for terrestrial environmental adaptation and intraspecific geographic-lineage diversification in ectothermic animals, yet there remains a lack of systematic studies on its underlying genetic mechanisms and evolution. To address this problem, we employed the widely distributed rice pest, the Chilo suppressalis, as a model to explore the genetic mechanisms and evolutionary history of freeze-tolerance. First, we systematically characterized its antifreeze mechanisms by performing functional validation of potential key genes in laboratory-reared lines. This revealed the functional roles of glycerol biosynthesis in freeze-tolerance, including the triacylglycerol-originated pathway via triacylglycerol lipase (Tgl) hydrolysis and the glycogen-originated pathway via α-amylase (Aa) and maltase (Ma) hydrolysis, as well as the roles of the cellular chaperones Hsc70 and Hsf1. Then, we investigated the evolution of freeze-tolerance by collecting representative geographical samples and performing population genetic analyses, which suggested differentiated strategies of cold adaptation in different geographic populations. Taken together, our findings demonstrate the functional basis of cold resistance in Chilo suppressalis and reveal the evolutionary history of freeze-tolerance in natural populations, providing insights into organismal freeze-tolerance and clues for pest control.

Changes of collagen content in lung tissues of plateau yak and its mechanism of adaptation to hypoxia.

Collagen is crucial for tissue structure, functional maintenance, and cellular processes such as proliferation and differentiation. However, the specific changes in collagen expression and its associated genes in the lung tissues of yaks at high altitudes and their relationship with environmental adaptation remain poorly understood. Studying differences in the content of collagen fibers and gene expression between yaks at high (4,500 m) and low (2,600 m) altitudes, as well as between cattle at low altitudes (2,600 m). Using Masson staining, we found that the collagen fiber content in the lung tissues of yaks at low altitude was significantly higher compared to yaks at high altitude and cattle at the same altitude (P < 0.05). It was revealed through transcriptomic analyses that genes differentially expressed between high and low altitude yaks, as well as between low altitude yaks and cattle, were notably enriched in pathways related to cell adhesion, collagen synthesis, focal adhesion, and ECM-receptor interactions. Specifically, genes involved in mesenchymal collagen synthesis (e.g., COL1A1, COL1A2, COL3A1), basement membrane collagen synthesis (e.g., COL4A1, COL4A2, COL4A4, COL4A6), and peripheral collagen synthesis (e.g., COL5A1, COL6A1, COL6A2, COL6A3) were significantly upregulated in the lung tissues of yaks at low altitude compared to their high altitude counterparts and cattle (P < 0.05). In conclusion, yaks at lower altitudes exhibit increased collagen synthesis by upregulating collagen gene expression, which contributes to maintaining alveolar stability and septal flexibility. Conversely, the expression of collagen genes in yak lung tissues was down-regulated with the increase in altitude, and it was speculated that the decrease in collagen may be used to constrain the function of elastic fibers that are more abundant at high altitude, so as to enable them to adapt to the harsh environment with hypoxia and high altitude. This adaptation mechanism highlights the role of collagen in environmental acclimatization and contributes to our understanding of how altitude and species influence collagen-related physiological processes in yaks.

Self-adaptive radiation recuperator with double phase transition temperature switches based on VO2 intelligent films

Developing renewable energy for heating and cooling to achieve carbon neutrality and environmental protection is of great significance. The combination of photothermal (PT) and radiative cooling (RC) technology to continuously obtain energy throughout the day is gradually attracting interest, in which vanadium dioxide (VO2) intelligent phase transition film serves as a bridge between the daytime PT mode and the nighttime RC mode. The high phase transition temperature of VO2 poses a challenge to environmental adaptability and dynamic switching in practical applications. In this work, a novel self-adaptive radiation recuperator with double phase transition temperature (37 °C and 68 °C) switches is proposed to exchange energy from the sun and outer space by radiation. Compared with VO2 and W-doped VO2 single-layer structure, this method has a higher self-adaptability to easily achieve the phase transition temperature of mode switching. The absorptivity of the radiation recuperator is 0.75 in the solar band (0.3–2.5 μm), and the emissivity switching capability is present from 0.3 to 0.86 in the atmospheric window band (8–14 μm). The transition mode generated by the presence of double phase transition temperature improves temperature self-adaptability and improves energy collection efficiency in dynamic environments.

A telomere-to-telomere Eucalyptus regnans genome: unveiling haplotype variance in structure and genes within one of the world’s tallest trees

BackgroundEucalyptus regnans (Mountain Ash) is an Australian native giant tree species which form forests that are among the highest known carbon-dense biomasses in the world. To enhance genomic studies in this ecologically important species, we assembled a high-quality, mostly telomere-to-telomere complete, chromosome-level, haplotype-resolved reference genome. We sampled a single tree, the Centurion, which is currently a contender for the world’s tallest flowering plant.ResultsUsing long-read sequencing data (PacBio HiFi, Oxford Nanopore ultra-long reads) and chromosome conformation capture data (Hi-C), we assembled the most contiguous and complete Eucalyptus reference genome to date. For each haplotype, we observed contig N50s exceeding 36 Mbp, scaffold N50s exceeding 43 Mbp, and genome BUSCO completeness exceeding 99%. The assembled genome revealed extensive structural variations between the two haplotypes, consisting mostly of insertions, deletions, duplications and translocations. Analysis of gene content revealed haplotype-specific genes, which were enriched in functional categories related to transcription, energy production and conservation. Additionally, many genes reside within structurally rearranged regions, particularly duplications, suggesting that haplotype-specific variation may contribute to environmental adaptation in the species.ConclusionsOur study provides a foundation for future research into E. regnans environmental adaptation, and the high-quality genome will be a powerful resource for conservation of carbon-dense giant tree forests.

Concentration Techniques in the Classroom for Children with ADHD, in an Educational Unit in the Province of Santa Elena

This study analyzes the effectiveness of various concentration techniques applied in classrooms for children with Attention Deficit Hyperactivity Disorder (ADHD) in an educational unit in Santa Elena. Employing a mixed-methods approach, surveys and interviews with teachers were examined, and the behavior of students with ADHD was observed. The findings suggest that strategies like environmental adaptation, use of visual and auditory signals, and positive reinforcement are effective in enhancing concentration and academic performance of these students. It is concluded that the implementation of specific concentration techniques, tailored to the size and resources of each institution, is crucial to support students with ADHD, thereby improving their academic performance and satisfaction.

DEVELOPING INTERCULTURAL COMPETENCE IN TOURISM STUDENTS ALONGSIDE LANGUAGE LEARNING

This paper explores the development of intercultural competence in tourism students alongside language learning, emphasizing its critical role in preparing students for the global tourism industry. Drawing from Byram’s framework of intercultural communicative competence and Deardorff’s assessment models, the study highlights the integration of language and culture in educational settings. It also analyzes the contributions of intercultural education programs, showing how they enhance students’ cultural sensitivity and communication skills. The findings demonstrate the necessity of fostering intercultural awareness and competence to improve students’ professional adaptability in diverse cultural environments.

The filamentous γ-prefoldin chaperone is not essential for growth and thermal adaptation in Methanocaldococcus jannaschii.

Elucidating the role of molecular chaperones in extremely thermophilic archaea, including the gamma prefoldin (γPFD) in the deep-sea methanogen Methanocaldococcus jannaschii, is integral to understanding microbial adaptation to hot environments. This study focuses on genetically engineered knock-out and overexpression strains to evaluate the importance of γPFD in the growth and thermal tolerance of M. jannaschii. An in-depth analysis of cell growth, morphology and transcriptional responses to heat stress revealed that although the gene encoding γPFD is substantially upregulated in response to heat shock, the γPFD is not indispensable for high-temperature survival. Instead, its absence in the knock-out strain is compensated for by the upregulation of several proteolytic proteins in the absence of heat shock, nearly matching the corresponding transcription profile of selected transcripts for proteins involved in protein synthesis and folding in the wild-type strain following heat shock, using quantitative reverse-transcription PCR (RT-qPCR). These findings bridge environmental adaptation with molecular biology, underscoring the versatility of extremophiles and providing a deeper mechanistic understanding of how they cope with stress.

Solvent‐Induced Dynamic Bond Regulation for Constructing Adaptive Lubricating Hydrogels with Switchable Tribological Performance and Environmental Adaptability

AbstractAdaptive lubricating hydrogels (ALH) show promise for reducing friction and energy consumption in various industrial applications. However, retarded switchable tribological performance and poor environmental adaptability limit their integration into application devices. Herein, a dynamic bond regulating strategy based on solvent conversion for producing an ALH with highly switchable tribological performance and decent environmental tolerance is proposed. By incorporating dynamic B─O bonds into the sodium alginate (SA) framework, these bonds transition between associative and dissociative states, facilitated by solvent conversion between glycerol and ethanol. This process modulates the mechanical modulus of the SA network, allowing for achieving highly switchable tribological performance. Furthermore, the inclusion of glycerol not only as a modulus regulator but also serves as an antifreeze component to impart the ALH with superior antifreeze and heat resistance properties, thus allowing the ALH to demonstrate excellent environmental adaptability. As a result, the resulting ALH exhibits highly switchable lubrication behavior, with a dynamically adjustable coefficient of friction (COF) between 0.022 and 0.157, and maintains consistent lubrication performance under a harsh environment (−40–60 °C), representing the state‐of‐the‐art in reported ALHs. This advancement allows for the development of intelligent brake devices (IBD), demonstrating potential applications in controlling drone speed.

Chromosome‐level genome assembly of a rare karst‐growing Rhododendron species provides insights into its evolution and environmental adaptation

AbstractRhododendron is a significant plant genus, with over 600 identified species in China. The subgenus Hymenanthes holds the largest number of Rhododendron germplasms and showcases strong environmental adaptability. However, there remains a lack of understanding regarding Rhododendron's evolution and environmental adaptations. Rhododendron bailiense Y.P.Ma, C.Q.Zhang &amp; D.F.Chamb., an exceedingly rare species, thrives in the alkaline karst landforms of Guizhou, southwest China, different from the typical growing environment of other Rhododendron species. In this study, we present a chromosome‐level genome assembly of R. bailiense, revealing a genome size of 923.3 Mb, a contig N50 of 24.5 Mb, and a total of 47 567 predicted genes. An evolutionary analysis indicated that R. bailiense diverged from its ancestors prior to the other subgenus Hymenanthes rhododendrons, with the expanded and contracted genes being notably enriched in “stress response” and “growth,” respectively. Rhododendron bailiense is predominantly found on limestone soil in the mountains of Guizhou, with only two wild populations known. The genome of R. bailiense contained a high copy number of ankyrin repeat (ANK) and Ca2+‐ATPase (CAP) genes, primarily involved in Ca2+ transport, shedding light on how R. bailiense copes with karst high‐calcium stress. In contrast, the structures of the ANKs displayed unique characteristics, while the CAPs showed conservatism. The R. bailiense genome provides new insights into the adaptation and evolutionary history of Rhododendron plants in karst environments, potentially offering valuable information for adaptive breeding and ecological enhancement in such challenging settings.

Progress in Research on Terpenoid Biosynthesis and Terpene Synthases of Lauraceae Species

Lauraceae, an important family of Angiospermae, comprises over 2500 species widely distributed in tropical and subtropical evergreen broad-leaved forests. This family is renowned for its rich resource of terpenoids, particularly monoterpenes, sesquiterpenes, and diterpenes. These compounds not only impart specific scents to Lauraceae species but also play crucial roles in plant growth, development, and environmental adaptation. These compounds also possess extensive bioactivities, such as antioxidant, antibacterial, anti-inflammatory, and neuroprotective effects, making them valuable in the fields of perfumery, cosmetics, food, and medicine, and thus holding significant economic value. Recent advancements in high-throughput technologies, especially genomics, transcriptomics, and metabolomics, have significantly advanced our knowledge of the chemical constituents and biosynthetic pathways of terpenoids in Lauraceae species. Such progress has also shed light on the diversity and functionality of the terpene synthases (TPSs) gene family, a key enzyme involved in terpenoid biosynthesis. This paper reviews the latest research findings on the biosynthetic pathways of terpenoids and their key enzyme-encoding gene families in Lauraceae plants. We also analyze the evolutionary patterns of TPS gene family members of four Lauraceae species at the whole-genome level and summarize their mechanisms of action in secondary metabolite synthesis. Furthermore, this paper highlights the current research challenges and proposes prospects, such as the complexity of gene families, the uncertainties in functional predictions, and unclear regulatory mechanisms. Our objective is to provide scientific foundations for the in-depth analysis of terpenoid biosynthesis mechanisms and the development and utilization of natural products in Lauraceae plants.

A theoretical framework for human-centered intelligent information services: A systematic review

Intelligent Information Services (IIS) employ Artificial Intelligence (AI)-based systems to provide information that matches the user's needs in diverse and evolving environments. Acknowledging the importance of users in AI-empowered IIS success, a growing number of researchers are investigating AI-empowered IIS from a user-centric perspective, establishing the foundation for a new research domain called “Human-Centered Intelligent Information Services” (HCIIS). Nonetheless, a review of user studies in AI-empowered IIS is still lacking, impeding the development of a clear definition and research framework for the HCIIS field. To fill this gap, this study conducts a systematic review of 116 user studies in AI-empowered IIS. Results reveal two primary research themes in user studies in AI-empowered IIS: human-IIS interaction (including user experience, system quality, user attitude, intention and behavior, information quality, and individual task performance) and IIS ethics (e.g., explainability and interpretability, privacy and safety, and inclusivity). Analyzing research gaps within these topics, this study formulates an HCIIS research framework consisting of three interconnected elements: human values and needs, environment, and service. The interconnections between each pair of elements identify three key research domains in HCIIS: interaction, ethics, and evolution. Interaction pertains to the facilitation of human-IIS interaction to meet human needs, encompassing topics including human-centered theory, evaluation, and the design of AI-empowered IIS interaction. Ethics emphasize ensuring AI-empowered IIS alignment with human values and norms within specific environments, covering topics like general and context-specific AI-empowered IIS ethical principles, risk assessment, and governance strategies. Evolution focuses on addressing the fulfillment of human needs in diverse and dynamic environments by continually evolving intelligence, involving the enhancement of AI-empowered IIS environmental sensitivity and adaptability within an intelligent ecosystem driven by technology integration. Central to HCIIS is co-creation, situated at the intersection of interaction, evolution, and ethics, emphasizing collaborative information creation between IIS and humans through hybrid intelligence. In conclusion, HCIIS is defined as a field centered on information co-creation between IIS and humans, distinguishing it from IIS, which focuses on providing information to humans.

Key Technologies for Autonomous Fruit- and Vegetable-Picking Robots: A Review

With the rapid pace of urbanization, a significant number of rural laborers are migrating to cities, leading to a severe shortage of agricultural labor. Consequently, the modernization of agriculture has become a priority. Autonomous picking robots represent a crucial component of agricultural technological innovation, and their development drives progress across the entire agricultural sector. This paper reviews the current state of research on fruit- and vegetable-picking robots, focusing on key aspects such as the vision system sensors, target detection, localization, and the design of end-effectors. Commonly used target recognition algorithms, including image segmentation and deep learning-based neural networks, are introduced. The challenges of target recognition and localization in complex environments, such as those caused by branch and leaf obstruction, fruit overlap, and oscillation in natural settings, are analyzed. Additionally, the characteristics of the three main types of end-effectors—clamping, suction, and cutting—are discussed, along with an analysis of the advantages and disadvantages of each design. The limitations of current agricultural picking robots are summarized, taking into account the complexity of operation, research and development costs, as well as the efficiency and speed of picking. Finally, the paper offers a perspective on the future of picking robots, addressing aspects such as environmental adaptability, functional diversity, innovation and technological convergence, as well as policy and farm management.

RoboMan: An Adult-Sized Humanoid Robot with Enhanced Performance, Inherent Stability, and Two-Stage Balance Control to Facilitate Research on Humanoids

Creating an adult-sized humanoid robot with stable walking capabilities is a major challenge in robotics. While many renowned research groups focus on robots for perilous work environments and precision tasks, our approach simplifies balance control, making it accessible to robotics research groups and educational institutes. This facilitates the development of complex functionalities such as vision and object manipulation for adult-sized humanoids. This research article introduces RoboMan II, an advanced version of RoboMan I, which won the most prestigious award in all humanoid robot leagues at RoboCup 2016 due to its exceptional performance in walking and playing soccer. RoboMan II features significant improvements in performance, inherent stability, recovery after falls, and balance control. To facilitate its development, RoboMan II is lighter and incorporates a modified foot and parallel structure for its leg to boost its inherent stability, along with a two-stage balance control system for Immediate Response and Gradual Adaptation, enhancing its adaptability in various environments. Our simulation results demonstrate that RoboMan II’s walking stability on flat surfaces improved significantly in the face of minor perturbations, with the number of steps within the stable region increasing from 24%, with only the immediate controller to 58% when both controllers were used. Similar improvements were observed on inclined surfaces. Additionally, the 3D CAD files for all of the robot parts are released as open source in conjunction with this paper to facilitate reproduction and further innovation. The forthcoming RoboMan III will incorporate custom servo motors for increased speed, torque, and enhanced fall recovery, preventing disengagement of the gear box after a fall. It promises to be an invaluable asset for research and practical applications in humanoid robotics.

Rational construction of ZnIn2S4/Co3Se4 with boosted photocatalytic hydrogen production through cooperate with S-scheme heterojunction and photothermal effect

The rational design of excellent visible light photocatalysts that efficiently utilize the solar spectrum is urgently needed. In this work, ZnIn2S4 (ZIS) and Co3Se4 (CS) were coupled by a multistep process involving simple ultrasonic self-assembly and calcination to form ZnIn2S4/Co3Se4 (ZIS/CS) photocatalysts with synergistic S-scheme heterojunctions and photothermal effects, which realized efficient photocatalytic hydrogen (H2) production with optimal H2 yield of 2.46 mmol h−1 g−1, superior to pure ZIS (0.47 mmol h−1 g−1) by a factor of 5.23. The excellent cyclic stability and wide environmental adaptability to the ionic environment of water of ZIS/CS were proved. The positive impaction of photothermal effect on the H2 yield of ZIS/CS was investigated and confirmed by the temperature change of photocatalysts powder or photocatalytic system under light irradiation. In addition, based on a series of characterization analyses and first-principle simulation calculations, a charge transfer pathway for ZIS/CS S-scheme heterojunctions was proposed. This work provides valuable ideas and feasible research methods for the design of stable and practical photocatalysts.

Eutectogel adhesives with underwater-enhanced adhesion to hydrophilic surfaces and strong adhesion in harsh environments

It has been a challenge to achieve strong adhesion strength for gel adhesives in water. In this study, a novel eutectogel adhesive is synthesized via one-step photoinitiated polymerization of N-vinylpyrrolidone (NVP) in deep eutectic solvent (DES). The abundant hydrogen bonding interactions and the hydrophilic polyvinylpyrrolidone network structure endow the eutectogel with excellent adhesion to both hydrophilic and hydrophobic surfaces in air and underwater. Moreover, for hydrophilic substrates, the underwater adhesion strength of the eutectogel adhesives is 1.3 times larger than that in air, demonstrating an underwater-enhanced adhesion effect. In contrast, for hydrophobic substrates, the underwater adhesion strength is lower than in air. Furthermore, strong adhesion performance is maintained even in boiling water, strong acidic medium, strong basic medium, and organic solvents. The experimental and simulation results have unveiled the underwater adhesion enhancement mechanism of the eutectogel. It is believed that the designed eutectogel will show great promise in the development of the next-generation of gel adhesives with underwater adhesion capabilities and high environmental adaptability.

Eco-friendly, high-hydrophobic polybutylene succinate foam for oil-water separation

Polybutylene succinate (PBS) is an excellent biodegradable resin with good processability and toughness. The inherent hydrophobicity of this material makes it unique for the preparation of oil-water separation materials. In this paper, PBS foams with high hydrophobicity were prepared by the non-solvent induced phase separation (TINIPS) method using N, N-dimethylformamide (DMF) as a good solvent and anhydrous ethanol as a non-solvent. The effect of PBS concentration on the wettability and micro-morphology of this foam was experimentally investigated. The results showed that the foam had an optimal microporous structure with a water contact angle as high as 145° when the concentration of PBS was 30 %. It was further found that the saturated adsorption capacity of the foam was 5.55–12.39 times its mass and remained strong after 10 adsorption tests. Finally, the environmental adaptability of foams had been studied. The foams maintained their superhydrophobic and oil-absorbing properties in the presence of strong acids, strong bases, saturated sodium chloride solutions, and repeated abrasion. In addition, with the help of a pump-assisted adsorption device, oil-water mixtures can be separated continuously and quickly. This showed that the material had a broad application prospect in oil-water separation.

Predictors of Sustainable Tourism Development during the Post-Pandemic Period in Bangladesh

The goal of this study was to examine the predictors of sustainable tourism development during the post-COVID-19 pandemic period in the context of Bangladesh. Quantitative-type research was applied, and this study used a descriptive research design. A standardized questionnaire was used to collect 302 data points from actual indigenous tourists using an online purposive sampling method. A partial least squares structural equation modeling (PLS-SEM) approach was used to evaluate the data and test the hypotheses. The results of the PLS-SEM analysis method demonstrate that environmental integrity, social equity, economic prosperity, and technological adaption had a positive relationship with sustainable tourism development during the post-COVID-19 pandemic period in Bangladesh. This research article provides practical guidelines for tourism authorities (BTB, BPC, and so on) and stakeholders on how to effectively impact environmental integrity, social equity, economic prosperity, and technological adaption on sustainable tourism development during the post-COVID-19 pandemic period in the context of Bangladesh. This study recommends that influential strategic factors be utilized to develop a sustainable tourism business in Bangladesh, positioning it as an emerging tourism destination.

Utilizing ChatGPT for On-the-Fly Decision-Making in Autonomous Systems

In the realm of autonomous systems, rapid and efficient decision-making is critical to ensure optimal performance and adaptability in dynamic environments. This paper explores the application of ChatGPT, a large-scale language model, in on-the-fly decision-making within autonomous systems. By leveraging ChatGPT's capabilities in natural language processing, contextual understanding, and real-time response generation, the study demonstrates how it can support autonomous agents in interpreting situations, generating actionable insights, and making informed decisions. The integration of ChatGPT into autonomous systems provides a flexible and scalable approach to improving decision accuracy and response times in unpredictable scenarios. This research investigates the benefits, challenges, and potential use cases, highlighting the model's contributions to enhancing autonomy in various fields such as robotics, self-driving vehicles, and intelligent drones.

The Impact of Wind Movement on Providing Thermal Comfort in Urban Design

The wind movement is a crucial factor in enhancing thermal comfort, forming an essential part towards friendly and sustainable urban environment. Air movement, as a prominent climatic factor, reduces heat stress with improving ventilation quality. Effective natural ventilation and heat stress mitigation can be achieved by orientation, planning and shaping the urban blocks in urban environments. Air movement represents the most important element in improving environmental adaptation, as the rapid airflow reaching buildings can significantly reduce their temperature. Site planning requires precise knowledge of the main wind directions and speeds. The research utilized the ENVI-met Models program for modeling urban environments and predicting thermal effects in the built environment. This program plays a crucial role in understanding and analyzing environmental conditions and their impact on thermal comfort. The research addressed the knowledge gap and lack of local studies in highlighting the role of wind movement in enhancing thermal comfort in urban environments using ENVI-met Models. The research aimed to provide specific knowledge in measuring wind movement and its role in enhancing thermal comfort in urban environments using the program. The research hypothesized that analyzing and modeling wind movement with ENVI-met Models can effectively contribute to understanding and improving thermal comfort in urban environments. One of the key findings is that studying the impact of wind movement with this program is essential for providing scientific and technical foundations to improve urban design and enhance thermal comfort in urban areas, promoting sustainability and environmental quality in cities