Entry Of Foreign Body Research Articles

Foreign Body Granuloma Originating From the Lateral Process of Malleus: A Case Series of 19 Children.

A special presentation of foreign body granuloma originating from the lateral process of the malleus (FBGLP) was noted in the absence of a history of foreign body entry into the external auditory canal (EAC). This study reported the clinical features, pathology, and prognosis of patients with FBGLP. Retrospective study. Shandong Provincial ENT Hospital. Nineteen pediatric patients (age, 1-10 yr) with FBGLP. Clinical data were collected from January 2018 to January 2022. Clinicopathologic characteristics of the patients were analyzed. All patients had an acute course, and were within 3 months of ineffective medical treatment. The most common symptoms were suppurative (57.9%) and hemorrhagic (42.1%) otorrhea. FBGLP imaging examinations demonstrated a soft mass blocking the EAC without bone destruction and occasionally concomitant effusion in the middle ear. The most common pathologic findings were foreign body granuloma (94.7%,18/19), granulation tissue (73.7%, 14/19), keratotic precipitate (73.7%, 14/19), calcium deposition (63.2%, 12/19), hair shafts (47.4%, 9/19), cholesterol crystals (5, 26.3%), and hemosiderin (15.8%, 3/19). Foreign body granuloma and granulation tissue showed higher expression levels of CD68 and cleaved caspase-3 than did the normal tympanic mucosa, whereas Ki-67 levels were similarly low in all tissues. The patients were followed up for 3 months to 4 years without recurrence. FBGLP is caused by endogenous foreign particles in the ear. We recommend the trans-external auditory meatus approach for FBGLP surgical excision, as this shows promising outcomes.

AN OVERVIEW OF FIRST AID BEHAVIOR IN TODDLER CHILDREN WHO FELL IN THE WORKING AREA OF THE BERAKIT PUBLIC HEALTH CENTER 2021

Children aged 1 to 3 years are the most critical period because 80% of brain growth occurs at that age or known as the Golden age (Nursalam, 2005). Based on the stages of growth and development of toddler-age children, it is necessary to get supervision from parents because in carrying out their activities children do not pay attention to the dangers that exist around them (Nursalam, 2005). According to dinkes Kepri (2014), the prevalence of injury events in toddler-aged children is injury (8.9%), drowning accidents (20.6%), bone fractures (2.6%), burns (5.3%), foreign body entry (9.7%), unexpected injuries (8.7%), and poisoning (10.26%). Toddler injuries can be prevented, one of which is with good supervision from parents (Arvin, 2000). This study aims to provide an overview of first aid behavior in toddler children who fall in the work area of the rafted health center. The total sample of this study was 30 people. The sampling technique uses a non-probability technique, namely a saturated sample or often called total sampling, where all members of the population are used as samples. In this study, it was known that respondents had alevel of good behavior (80%). This is influenced by several factors, namely education, sources of information, and experience. The results of this study are expected to add insight, contribute to science, especially those related to the problem of first aid in fallen toddler children and contribute thoughts for parents regarding first aid in fallen toddler children.

Saúde Ocupacional aplicada aos Pavimentadores de Estradas

Introduction/framework/objectives It is not uncommon for Occupational Health teams to have a client in the road paving sector; however, literature for this area is sparse. The aim of this article is to summarize the most pertinent and recent articles published on the subject. Methodology This is a Bibliographic Review, initiated through a search carried out in August 2021 in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Contents The IARC (International Agency for Research on Cancer) classified the asphalt used for paving roads as possibly carcinogenic to humans (group 2b), due to polycyclic aromatic hydrocarbons. However, epidemiological studies do not show clear evidence of a higher incidence/prevalence of diseases of this type, although the risk may be different, depending on the route of entry (inhaled versus cutaneous) and the specific composition. There are also aliphatic hydrocarbons, cyclic alkanes and heterocyclic compounds. The association with different types of cancers is inconclusive but still stronger for lung versus skin. Some of these substances can cause chromosomal instability which, in turn, some argue that it can lead to cancer pathology. Discussion and Conclusions In the research carried out there was only data related to the chemical agents inserted in the asphalt; no references were found to other Occupational Risk/Risks Factors, such as other chemical agents, dust; noise, cut, vibrations associated with different machines; physical loads/efforts, forced/maintained postures, falling to the same level or at different levels, and eventual burial; ultraviolet radiation and thermal discomfort or trampling. As for the chemical risk, most authors consider that some substances included in the composition of the asphalt, especially under certain technical conditions (equipment, temperature, asphalt subtypes), may be carcinogenic to humans. However, even at this level, collective or individual protection measures are not mentioned, in order to provide concrete guidance for those who have clients in this sector. In the context of the former, it can be assumed that it would be pertinent to promote the rotation of tasks, to choose the types of asphalt considered less toxic (whenever possible) and the equipment that worked at lower temperatures, with less noise and vibrations; promote good maintenance of machines and purchase safer models; as well as organizing training and access to adequate Occupational Health services. In turn, at the level of Personal Protective Equipment, one could use mask/visor, hat/cap, uniform, glasses (for ultraviolet radiation and entry of foreign bodies), sun protection cream, ear protection, gloves (for cutting/abrasion and/or vibration), knee braces and/or abdominal restraint straps. It would be important for some Occupational Health teams working in the area to better study the sector and develop valid knowledge about the gaps mentioned, disseminated through publication in journals of the area. KEYWORDS: road paving, road pavers, occupational health, occupational medicine and occupational risks.

Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein.

P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells. P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer medicines and confers resistance. Due to its wide specificity, several attempts have been made to block the action of P-gp to restore the efficacy of anticancer drugs. The major goal has been to create molecules that either compete with anticancer medicines for transport or function as a direct P-gp inhibitor. Despite significant in vitro success, there are presently no drugs available in the clinic that can “block” P-gp–mediated resistance. Toxicity, unfavourable pharmacological interactions, and a variety of pharmacokinetic difficulties might all be the reason for the failure. On the other hand, P-gp has a significant effect in the body. It protects the vital organs from the entry of foreign bodies and other toxic chemicals. Hence, the inhibitors of P-gp should not hinder its action in the normal cells. To develop an effective inhibitor of P-gp, thorough background knowledge is needed in this field. The main aim of this review article was to set forth the merits and demerits of the action of P-gp on cancer cells as well as on normal cells. The influence of P-gp on cancer drug delivery and the contribution of P-gp to activating drug resistance were also mentioned.

Penetrating Facial Injury by Motorcycle Gear Shifter Lever: A Case Report

Background: Penetrating facial injury can cause injury to the bone and soft tissue surrounding. Penetrating facial injury caused by organic foreign bodies or metal material increases the risk of infection in the wound. Identification of the location of the entry of foreign bodies, whether the vital organs, the presence of injury to the nerves, vascular, visual, and other muscle damage is very important to do. For that immediate and optimal treatment can be applied to reduce morbidity and mortality.
 Case presentation: A 13 years old boy arrived in ER admission with penetrating facial injuries. A corpus alienum penetrated the patient’s face at the medial meatus of the right eye along with bleeding from the nose and around the wound. Evaluation and management of the penetrating facial injury were performed in accordance with the ATLS protocol. The aim of management in penetrating facial injuries is to remove the foreign body with minimal trauma to surrounding structures and to maintain normal function and optimal appearance. The patient underwent emergency surgery the remove corpus alienum and wound exploration under general anesthesia. Postoperative evaluation shows no bleeding or signs of infection, no visual impairment, and tear flow were found.
 Conclusion: Penetrating facial injury due to motorcycle gear shifter lever is rare. Good Management of penetrating facial injury will give satisfactory results.

Gagging Assessment Scale: A Reliable Tool For Assessing Association Between Gagging And Dental Fear In Children Prior Dental Treatment- A Cross-Sectional Pilot Study

Gagging is a normal protective defence mechanism of our body that prevents entry of foreign bodies into the airway, which can create undue havoc during dental treatment especially in children. The present study aims to assess the prevalence of gagging and any of its existing association with dental fear and anxiety in children prior to dental treatment. A cross-sectional pilot study design was conducted in South Indian children (age group: 3-10 years) having no history of underlying psychological and systemic ailment. Different assessment scales of gagging (Gagging Assessment Scale [GAS], Shorter Objective Form of Gagging Problem Assessment [GPA-SF]/OGPA), dental fear (Children’s Fear Survey Schedule Dental Subscale [CFSS-DS]) and anxiety (Modified Dental Anxiety Scale- Faces [MDASF]) were administered to evaluate their response prior to the treatment. Younger children specifically females demonstrated severity of gagging reflex, which was directly correlated to their higher perception of dental fear and anxiety. However, no conclusive evidence of an association between gagging, dental fear and anxiety was ascertained. Prior knowledge of the gagging problem in children can help clinicians to effectively modify the treatment modalities for successful outcomes, while GAS could be a reliable tool for assessing its severity in children prior to dental treatment.

Characteristics and outcomes of emergency department patients with a foreign body that entered through the ear, nose or mouth: a 10-year retrospective analysis.

Foreign bodies in the ear, nose and throat commonly necessitate emergency department visits. This retrospective study was conducted on emergency department visits from January 2010 to December 2019 to determine characteristics and clinical prognoses of ENT patients. Patients were divided into three groups according to foreign-body entry route; patient characteristics and clinical findings were compared between groups. Of 676 142 emergency department visits, 10 454 were because of ENT-related foreign bodies. The mean (± standard deviation) age of subjects was 24.0 (± 23.4) years, and 5176 patients were male (49.5 per cent). The most common entry route was the mouth (74.5 per cent). Most patients (97.1 per cent) were discharged after emergency treatment. Intensive care and in-hospital mortality occurred only in the mouth group. Clinical findings differ depending on foreign-body entry route. After emergency treatment, most patients were discharged; some cases presented serious complications.

Knowledge Attitude and Awareness Of Dental Students About The Role Of Acupuncture In Controlling Gag Reflex

Introduction: Gagging is a normal reaction to safeguard the airway from foreign body entry. In some patients this is exaggerated and hence may hinder the dental treatment. There are many methods to control gagging and one of it is acupuncture which a traditional Chinese method. Aim: This survey is done to assess the knowledge attitude and awareness of dental students about the role of acupuncture in controlling gag reflex. Materials and methods : A questionnaire with 11 questions based in the acupuncture and its effect in gagging were prepared and distributed through an online link to a total of 80 students and the results were obtained. Results: 45% of the students are aware of acupuncture used for preventing gagging and no one have ever done acupuncture in their clinical practice. Conclusion: Awareness should be created about the acupuncture and its benefits in controlling the gag reflex since it is an effortless and effective treatment.

Melatonin and biological membrane bilayers: a never ending amity

Biological membrane, the most fluidic structure of a cell or an organelle, refrains the cells to progress toward apoptosis by sustaining their optimum environment. This bilayer-membrane equips all machineries required for cellular communication, limits the entry of foreign bodies, selectively transports molecules or ions depending on the need of the system but, it also acts as a first line defense against environmental insults. Due to the presence of a vast number of poly unsaturated fatty acids (PUFA), the biological membrane is highly prone to oxidative stress and as a consequence, acceleration in lipid peroxidation by free radicals, becomes a threat to cellular viability. Alterations in the biophysical state of bilayer caused by oxidative stress frequently occur in the in vivo as well as in vitro conditions. It has been well documented that the molecule, melatonin, exhibits profound coherence in neutralizing oxidative stress and thus, to normalize fluidity status of biological membranes. Aging associated decline in melatonin level with subsequent ascended lipid peroxidation and membrane viscosity found in almost all organisms further suggest the importance of melatonin in this context. Since disruption of membrane structure or even some modifications will cause a spectrum of diseases, keeping membrane intactness would be an adequate strategy to prevent these diseases. Considering the high permeability, safe and potent antioxidant capacity of melatonin, this molecule can be a superlative choice to alleviate membrane bilayer rigidity and its related ailments.

NANOVACCINATION: EVOLUTION AND REVIEW

Vaccination is often associated with the prevention of diseases, (i.e.) it prevents future malfunctions in our body. The root causes of most of the malfunctions are the microbes or pathogens which enter our body directly or indirectly. Thus, a war between these antigens and our cell system is broken out and to an extent, the immune system in our body helps in defeating the antigens, but certain antigens are capable enough to overcome the immunity of our body. These are generally auto-immune and also genetically inherited diseases. One big question that arises is do we have a solution that can monitor the activities of cells, tissues, and organs. Thus, we need an artificial mechanism that, like blood cells circulates in the bloodstream. This is the situation; where the idea of programmable nanobots comes into the picture wherein these nanometer-sized artificial systems circulate in the bloodstream and monitors Basal Metabolic Rate (BMR). Work functions of organs and entry of foreign bodies. So, any abnormalities in our body can be detected by the biosensors in the nanobots at the point of entry itself and the tracking system monitors it from outside. The early remedy can prevent the microbes to develop its activity to a vulnerable stage. It also helps in preparing the genes that malfunction due to mutation, chromosomal aberration, etc. Hence, we name this idea as NANOVACCINATION, i.e. prevention at the nano level.

Pattern of corneal disorders in Ekiti: A tertiary eye center experience.

Purpose:The cornea is the most significant refractive medium in the eye. Pathologies affecting the cornea usually have a great impact on vision. The etiology of corneal disorder varies from one geographical location to another. The objective of this study was to determine the pattern of corneal disorders at Ekiti State University Teaching Hospital, Ado-Ekiti.Materials and Methods:A retrospective study of case records of patients with cornea disorders over a 5-year period was carried out. Demographic characteristics, presenting visual acuity, and risk factor for cornea disorders were retrieved. Data were entered into the Statistical Package for the Social Sciences version 20, and statistical significance was inferred at P < 0.05.Results:Corneal disorders accounted for 3.3% of the eye disorders seen during the period of study. The median age was 37 years. Males outnumbered females giving a ratio of 1.9:1 and the age range from 0.25 to 92 years. There were more females than males in the 11–20 years’ age group. Students (84, 25.4%) and artisans (62, 18.8%) were the two leading occupational groups. Infectious cases constituted 27.2% of the cases. Visual acuity at presentation was <3/60 in 131 (39.7%) cases. Foreign body entry was the leading etiologic agent in 101 (30.6%) cases.Conclusion:Half of the patients were blind at presentation, and many of them presented after more than 1 week of the onset of symptoms. Corneal foreign body, trauma, and vernal keratoconjunctivitis were the leading known predisposing factors. There will be need to emphasize more on the role of protective eye devices among our people, especially those who engage in outdoor activities.

Fundamentals, challenges, and nanomedicine-based solutions for ocular diseases.

The eye consists of sensitive, compactly adjoined tissue structures which act as strong physical (static) and physiological (dynamic) barriers that prevent entry of foreign bodies into the eye. Together, these barriers reduce the bioavailability of topically and intraocularly administered medicaments thus demanding frequent drug administration for the treatment of chronic eye diseases. Hence, development of drug delivery systems (DDS) that can be retained in ocular tissues for longer durations can help to reduce the frequency of drug administration, whereas, delivery systems that traverse through ocular barriers may offer higher bioavailability of administered drugs to otherwise inaccessible ocular tissues. These objectives can be partially/fully achieved using nanoparticulate/colloidal DDS. Colloidal DDS, due to their nanodimensions, undergo internalization by cells which enables transport of drugs through ocular barriers. Furthermore, nanoparticles can prolong duration of drug release and can increase residence time of entrapped cargo molecules in ocular tissues. Together, these aspects facilitate a higher bioavailability, prolonged therapeutic effect and reduced frequency of drug administration for the effective treatment of chronic ocular diseases. Hence, nanocarriers have been widely explored for ophthalmic drug delivery applications. In this review, we discuss the anatomy of ocular tissues along with their barrier properties. We then discuss ocular diseases along with the various routes of drug administration and pathways of drug transport in the eye. The next section discusses the influence of physicochemical properties of therapeutic molecules on their ocular distribution and conventional and advanced (nanoparticulate/colloidal DDS) drug formulations that are used for the treatment of ocular diseases. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.

Management of Bullet Emboli to the Heart and Great Vessels.

Firearm-related injuries account for 20% of all injury-related deaths and are responsible for 105,000 injuries annually. The occurrence of bullet emboli to the heart is exceedingly rare. Given the rarity of emboli, controversy exists over management. The primary endpoint of this study is to establish a management algorithm for venous bullet emboli to the heart. A literature search was performed using PubMed and Google Scholar with the following search terms: cardiac bullet embolus, cardiac missile embolus, and bullet embolus. Any discoverable case report(s) or series after 1960 were included in the review. The following data points were collected: age, sex, presentation, imaging, foreign body entry site, foreign body destination site, management, and outcomes. Fifty-four articles met our search criteria. A total of 62 patients with thoracic venous bullet emboli were identified with the following distributions: right atrium (9.7%), right ventricle (54.8%), pulmonary arterial tree (32.3%), and intra-thoracic inferior vena cava (3.2%). Only 11.3% of patients had symptoms directly related to the cardiac venous emboli; however, all patients with acute symptoms underwent immediate intervention. Of those patients with bullet emboli to the pulmonary arterial tree, 45% were observed; whereas, only 20% with emboli to the right heart were observed. Those without signs or symptoms usually underwent an intervention (72.7%). Endovascular retrieval was successful in 53% of attempts. Of the endovascular attempts that failed, 28.6% were observed and 71.4% underwent open retrieval. Those who were asymptomatic and observed had no reported adverse sequelae during the follow-up. No mortalities were discovered in this review. Bullet emboli can prove to be a clinical challenge. Adjuncts such as X-ray, computed tomography, transthoracic, and/or transesophageal echocardiography help establish the emboli location. While observation in the asymptomatic patient is reasonable in some circumstances, most patients undergo removal. Removal of bullet cardiac emboli is safe with the availability of modern techniques.

Utilization of drugs in patients with road traffic accident injuries

Background: Drug utilization studies provide information on pattern of drug prescribing and consumption, occurrence of delayed adverse effects, cost influenced sales, and the volume of prescriptions having social, economic, and medical significance. Objective: The present study was designed with an objective to evaluate drug utilization in this field of pharmaceutical care. Materials and Methods: The present study was a retrospective, qualitative, cross-sectional, drug utilization study carried out for 1 year in Accident and Emergency Department of Khoula Hospital. Results: Results of the present study indicate that majority of patients complained dizziness by 24% and pain with 50%. Most common antibiotics used in prophylaxis and treatment were amoxiclav, cefuroxime, and ceftriaxone injections. As some cases complained of severe pain, they had received paracetamol, ibuprofen, diclofenac, and tramadol. The tetanus toxin injection was given as prophylaxis in 27.9% of cases against poisoning from entry of foreign bodies. Metoclopramide and promethazine are medications given to relieve nausea and vomiting. Analysis of results on use of medications for pain management has shown a significant (P < 0.01) correlation with road traffic injuries. Conclusion: We conclude from this study that majority of patients visiting accident are noted to have minor complications due to road traffic accidents (RTAs) and are treated successfully with most common and safe medications. However, we recommend future extensive studies considering the patients admitted to Inpatient Department and Intensive Care Unit to get clear information on pharmaceutical care provided to manage RTA and their complications.

Flexible bronchoscopy with multiple modalities for foreign body removal in adults.

ObjectivesAspiration of the lower airways due to foreign body is rare in adults. This study aimed to determine the outcome of patients who received flexible bronchoscopy with different modalities for foreign body removal in the lower airways.Patients and MethodsBetween January 2003 and January 2014, 94 patients diagnosed with foreign body in the lower airways underwent flexible bronchoscopy with different modalities, which included forceps, loop, basket, knife, electromagnet, and cryotherapy. The clinical presentation, foreign body location and characteristics, and applications of flexible bronchoscopy were analyzed.ResultsForty (43%) patients had acute aspiration, which developed within one week of foreign body entry and 54 (57%) had chronic aspiration. The most common foreign bodies were teeth or bone. More patients with chronic aspiration than those with acute aspiration were referred from the out-patient clinic (48% vs. 28%), but more patients with acute aspiration were referred from the emergency room (35% vs. 6%) and intensive care unit (18% vs. 2%). Flexible bronchoscopy with different modalities was used to remove the foreign bodies (85/94, 90%). Electromagnet or cryotherapy was used in nine patients to eliminate the surrounding granulation tissue before foreign body removal. In the nine patients with failed flexible bronchoscopy, eight underwent rigid bronchoscopy instead and one had right lower lung lobectomy for lung abscess.ConclusionsFlexible bronchoscopy with multiple modalities is effective for diagnosing and removing foreign bodies in the lower respiratory airways in adults, with a high success rate (90%) and no difference between acute and chronic aspirations.

Accidental Entry of Foreign Body in Maxillary Sinus—A Case Report

Extraction of the first molar or premolar is the commonest cause of oro-antral fistula. Management involves identification of the same, removal of any foreign body from the maxillary sinus, if present, followed by appropriate flap for closer. A case is presented when a gutta percha (GP) point was accidentally dislodged into the right maxillary sinus during preliminary diagnosis of the oro-antral fistula. The surgical management of the case is described and is the appropriate treatment plan.

Structure of the Neisserial outer membrane protein Opa₆₀: loop flexibility essential to receptor recognition and bacterial engulfment.

The structure and dynamics of Opa proteins, which we report herein, are responsible for the receptor-mediated engulfment of Neisseria gonorrheae or Neisseria meningitidis by human cells and can offer deep understanding into the molecular recognition of pathogen–host receptor interactions. Such interactions are vital to understanding bacterial pathogenesis as well as the mechanism of foreign body entry to a human cell, which may provide insights for the development of targeted pharmaceutical delivery systems. The size and dynamics of the extracellular loops of Opa60 required a hybrid refinement approach wherein membrane and distance restraints were used to generate an initial NMR structural ensemble, which was then further refined using molecular dynamics in a DMPC bilayer. The resulting ensemble revealed that the extracellular loops, which bind host receptors, occupy compact conformations, interact with each other weakly, and are dynamic on the nanosecond time scale. We predict that this conformational sampling is critical for enabling diverse Opa loop sequences to engage a common set of receptors.

An intraorbital metallic foreign body.

A 30-year-old male presented with diplopia for 20 days post occupational accident involving left side of his nose, while he was working with a nail gun. He was fully conscious and did not have any neurological deficits. Patient narrated the mechanism of injury and was sure that the nail fell down after hitting the left side of his nose. He had normal vision, but extra ocular movements were restricted and painful. Computed tomography (CT) scan revealed a curved metal object lodged in the posterior aspect of the left orbit extending diagonally from medial wall to the anterior-superior aspect of the orbital roof. The object was removed via a small surgical approach, inflicting least possible surgical trauma. Post surgery, the patient recovered with complete resolution of diplopia. The original aspects of this case are the lack of signs of a foreign body entry and its relative harmlessness in spite of its large size.

Glass foreign bodies inside the knee joint following intra- articular injection: A case report.

SummaryBackground:Foreign bodies inside the knee joint are not uncommon. However, the literature has no reports of a foreign body inside the knee joint, with no history of trauma.Case Report:Glass foreign bodies were found embedded inside the knee joint during arthroscopic washout for a middle aged male patient with knee osteoarthritis. The patient had no history of trauma and no scars or sign of entry of foreign bodies. It was found that these foreign bodies originated from glass vials broken while withdrawing medication for intra-articular injection of this knee in the past.Conclusions:To avoid similar incidents, the authors recommend using filter needles to withdraw medications from glass vials.

Rare foreign bodies in oro-facial regions

Accidental entry of foreign bodies into the oro-facial region could be due to trauma, therapeutic interventions or iatrogenic. Various foreign bodies and locations have been reported, for example, wood in the orbit, impression material in the maxillary sinus, tooth fragments in the orbit. All these cases presented with inflammatory reaction and formation of infected granuloma, pus discharging sinus and serious complications like intra-cranial abscesses. Foreign bodies sometimes migrate within the tissues and become symptomatic after a certain period of time. In these cases, it is very difficult to correlate the direct relation between the suspected foreign bodies with the present clinical symptoms. The removal of foreign bodies is often a surgical challenge due to a combination of difficulty in access and close anatomical relationship to vital structures. To prevent complications, foreign bodies should be diagnosed and removed on time.