BackgroundAnxiety disorder (AD) is considered one of the most difficult mental disorders to treat. The important factors causing this disease are negative self-awareness and excessive attention to negative emotional stimuli, which are related to excessive activity in the emotion generating brain area and cognitive control brain area imbalance. This study uses guided psychotherapy combined with innovation and entrepreneurship training for college students to intervene in their employment anxiety.Subjects and Methods74 individuals with high anxiety traits with a total score of over 63 (N=65) were screened among college students. Anxiety students were randomly divided into a conventional group and an experimental group. Leibowitz Anxiety Scale (LAS) was used. The conventional group of 37 people used normal guided psychotherapy, while the experimental group used guided psychotherapy combined with innovation and entrepreneurship training for college students to intervene in their employment anxiety.ResultsBefore the intervention, there was no significant difference in the scores of LAS, Shyness Scale, Self Rating Depression Scale, Fear Negation Scale, Self Efficacy Scale, and Trust Scale between the two groups. After the intervention, the scores of the experimental group were lower than those of the conventional group. The LAS scale scores of the experimental group significantly decreased.ConclusionsGuided psychotherapy combined with innovation and entrepreneurship training for college students can effectively alleviate students’ employment anxiety, and the guidance effect on anxiety is more sustainable compared to conventional methods.AcknowledgementResearch and Practice of Digital Resource Construction for the Academic Guidance of Master of Statistics in Tianjin University of Commerce in 2022 Graduate Education and Teaching Reform Research Project. (No.23YJSJG0104).