Entrepreneurial ecosystems in various geographical areas of the world are often compared in the context of entrepreneurship research. There are far fewer comparative studies on different types of ecosystems. In this study, a traditional entrepreneurial ecosystem based in Canada is compared with a digital entrepreneurial ecosystem specializing in life sciences, in Switzerland, bridging the gap between both and yielding previously unknown insights. The aim is twofold: to decipher both the differences and the similarities between the two models and to describe the predominant type of entrepreneurship in each case. The method consisted of a quantitative study of socio-economic data in combination with the administration of a qualitative analysis of interviews with—industry, government, and university—experts with links to one or the other ecosystem. The main findings showed that the traditional ecosystem had varied entrepreneurial support, public financial support, and collaborative networks between SMEs and start-ups, whereas in the specialized digital ecosystem, business support tended to be sector-specific with private financial support and networks emerging between multinationals and start-ups. Our study contributes to entrepreneurship research by showing that high-tech industries such as biotechnology and medical technology manage to go beyond a purely digital approach in digital ecosystems. The generic nature of the high-tech industries within the traditional ecosystem was the main driver of traditional entrepreneurship, while the sector-specific approaches of the industries within the specialized digital ecosystems were shown to drive innovative entrepreneurship.
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