The study aims to identify the role of e-commerce use through the efficiency of entrepreneurial competencies in directing the financial performance of companies listed on the Palestine Stock Exchange via financial performance indicators connected to e-commerce: sales value, and company value. The data for the study sample is gathered from the financial reports of all 49 companies listed on the Palestine Stock Exchange for the four sectors (commercial, service, industrial, and investment) over the 11 years of the study period, 2010 to 2020, resulting in a hypothetical sample size of 528 observations (11 years x 49 companies). A quantitative descriptive-analytical approach was employed, and the data was analyzed using SPSS and Stata software. The outcomes of the study have revealed a positive and significant relationship be- tween the employment of electronic commerce and the financial performance of businesses. In addition, it has been observed that Entrepreneurial competencies play a significant moderating role in the relationship between the use of e-commerce and the financial performance (sales value, company value) of companies listed on the Palestine Exchange. This is the first study to investigate Entrepreneurial competencies as a moderator between e-commerce utilization and business financial performance, based on previous knowledge in the field. The empirical findings of this study give managers and practitioners useful theoretical and practical insights for understanding the relationship between the deployment of e-commerce across all industries in hopes of enhancing company results.