The current employment situation is grim, and the era of science and technology is conducive to college students providing new opportunities for innovation and entrepreneurship. The inclusion of entrepreneurship education in college courses can open up more employment opportunities for students. Therefore, the educational environment is crucial for students’ employment choices. This paper conducted a questionnaire survey on 582 college students from nine universities in Fujian Province, China, to develop a relationship model between science and technology innovation perception, education, and entrepreneurial intention. The results show that: 1. Science and technology innovation perception education has been proven to have a direct positive influence on college students’ entrepreneurial intention; 2. Undergraduates work value orientation (including career orientation, mission orientation, and livelihood orientation) significantly affects entrepreneurial self-efficacy and thus entrepreneurial intention; and 3. Both work value orientation and entrepreneurial selfefficacy have a direct influence on entrepreneurial intention, but the influence of entrepreneurial self-efficacy is greater than that of work value orientation. Therefore, enhancing college students’ entrepreneurial self-efficacy is the main way to improve entrepreneurial intention. Based on this, to improve the entrepreneurial intention of college students, colleges and universities should strengthen science and technology innovation perception education, do a good job in student employment guidance, improve students’ self-efficacy, meet undergraduates’ diverse employment needs, and provide more entrepreneurship resources to undergraduates.