Entrapment Disorders Research Articles

Assessment of median nerve with magnetic resonance neurography in cases with carpal tunnel syndrome and controls

Background: Carpal tunnel syndrome (CTS) is a common peripheral nerve entrapment disorder that is diagnosed using clinical signs and symptoms and confirmed via nerve conduction studies (NCSs). While NCS is a semi-invasive procedure, magnetic resonance imaging (MRI) is a non-invasive diagnostic tool that detects macroscopic nerve abnormalities and evaluates a patient's surgical or medication treatment options. This study assessed magnetic resonance neurography (MRN)’s diagnostic and grading value by comparing it to electrodiagnostic studies in patients with CTS and healthy individuals. Methods: This was a cross-sectional study on 27 wrists with CTS and 27 healthy wrists. After history taking and physical examination, we employed an NCS to confirm and determine the severity of CTS, then MRN and diffusion tensor imaging (DTI) were used to calculate apparent diffusion coefficient (ADC), fractional anisotropy (FA), and cross-sectional area (CSA). Results: 18 patients with CTS (27 median nerves) and 15 healthy controls (27 median nerves) were evaluated. The mean FA in the CTS group was significantly lower (0.38 ± 0.05 vs. 0.45 ± 0.06, P < 0.001).The mean CSA and ADC were higher in patients with CTS but not statistically significant. FA’s diagnostic cut-off was 0.42, with a sensitivity of 70.4% and a specificity of 63%. Conclusion: MRN with DTI can be an effective and non-invasive diagnostic technique for the detection of CTS. The FA measure demonstrated adequate sensitivity and specificity for differentiating patients with CTS from healthy individuals.

Prevalence of Carpal Tunnel Syndrome Among the BDS Interns of the Dental Institutes in Lahore: A Cross-Sectional Study

Background: Carpal Tunnel Syndrome (CTS) is a prevalent nerve entrapment disorder characterized by pain, numbness, and functional impairment of the hand, significantly affecting dental professionals due to prolonged hand use and awkward postures.Objective: To assess the prevalence and associated risk factors of CTS among BDS interns in dental institutes of Lahore.Methods: A cross-sectional study was conducted among 177 dental interns from five dental institutes using convenience sampling. Demographic data and symptom severity were evaluated using the Boston Carpal Tunnel Questionnaire (BCTQ), and diagnosis was confirmed using the Phalen’s test. Pearson’s correlation and independent sample T-tests were applied using SPSS version 25. Ethical approval and informed consent were obtained per the Declaration of Helsinki.Results: CTS prevalence was 14.7% (n=26), with a higher rate in females (8.8%) compared to males (5.9%). CTS was significantly associated with female gender (p=0.013), higher BMI (p=0.011), left-hand dominance (p=0.01), and increased weekly caseload (p<0.05).Conclusion: The findings highlight a substantial CTS prevalence among dental interns, with gender, BMI, and workload being key risk factors, indicating a need for targeted ergonomic interventions.

Carpal tunnel syndrome.

Carpal tunnel syndrome (CTS) is the most common nerve entrapment disorder worldwide. The epidemiology and risk factors, including family burden, for developing CTS are multi-factorial. Despite much research, its intricate pathophysiological mechanism(s) are not fully understood. An underlying subclinical neuropathy may indicate an increased susceptibility to developing CTS. Although surgery is often performed for CTS, clear international guidelines to indicate when to perform non-surgical or surgical treatment, based on stage and severity of CTS, remain to be elucidated. Neurophysiological examination, using electrophysiology or ultrasonography, performed in certain circumstances, should correlate with the history and findings in clinical examination of the person with CTS. History and clinical examination are particularly relevant globally owing to lack of other equipment. Various instruments are used to assess CTS and treatment outcomes as well as the effect of the disorder on quality of life. The surgical treatment options of CTS-open or endoscopic-offer an effective solution to mitigate functional impairments and pain. However, there are risks of post-operative persistent or recurrent symptoms, requiring meticulous diagnostic re-evaluation before any additional surgery. Health-care professionals should have increased awareness about CTS and all its implications. Future considerations of CTS include use of linked national registries to understand risk factors, explore possible screening methods, and evaluate diagnosis and treatment with a broader perspective beyond surgery, including psychological well-being.

The Unpredictable Ulnar Nerve-Ulnar Nerve Entrapment from Anatomical, Pathophysiological, and Biopsychosocial Aspects.

Peripheral nerves consist of delicate structures, including a rich microvascular system, that protect and nourish axons and associated Schwann cells. Nerves are sensitive to internal and external trauma, such as compression and stretching. Ulnar nerve entrapment, the second most prevalent nerve entrapment disorder after carpal tunnel syndrome, appears frequently at the elbow. Although often idiopathic, known risk factors, including obesity, smoking, diabetes, and vibration exposure, occur. It exists in all adult ages (mean age 40-50 years), but seldom affects individuals in their adolescence or younger. The patient population is heterogeneous with great co-morbidity, including other nerve entrapment disorders. Typical early symptoms are paresthesia and numbness in the ulnar fingers, followed by decreased sensory function and muscle weakness. Pre- and postoperative neuropathic pain is relatively common, independent of other symptom severity, with a risk for serious consequences. A multimodal treatment strategy is necessary. Mild to moderate symptoms are usually treated conservatively, while surgery is an option when conservative treatment fails or in severe cases. The decision to perform surgery might be difficult, and the outcome is unpredictable with the risk of complications. There is no consensus on the choice of surgical method, but simple decompression is relatively effective with a lower complication rate than transposition.

Value of MUNE versus compound muscle action potential in assessing motor unit loss in patients with carpal tunnel syndrome

BackgroundThe most prevalent nerve entrapment disorder, known as carpal tunnel syndrome (CTS), is brought on by wrist-based median nerve compression. Focal demyelination progresses to axonal dysfunction as the condition worsens. In order to detect motor unit (MU) loos, this study compares two motor unit number estimation (MUNE) techniques with compound muscle action potential (CMAP) amplitude. The CMAP amplitude and MUNE of the median nerve in 137 hands of 70 neurophysiologically approved CTS patients, aged 40.27 ± 10.06 years were examined. Another 90 hands from 56 healthy volunteers who are age- and gender-matched serve the control group.ResultsIn contrast to 192.5 and 248.5 in controls, the median nerve values of incremental and adapted multipoint stimulation (aMPS) MUNE in CTS patients were, respectively, 111 and 133 (p < 0.0001). Patients with severe CTS compared to those with mild CTS using both methods had significantly lower MUNE. MUNE values are the same regardless of gender or hand dominance. In comparison to MUNE methods (cutoff values of 106.5 and 203, respectively), CMAP amplitude had a sensitivity and specificity of more than 60% in detecting MU loss (cutoff value of 6.85 mV). The CTS grading had no effect on the CMAP amplitude. MUNE values had positive with CMAP amplitude and negative with CTS grading and Phalen test positivity.ConclusionsWhen identifying motor nerve involvement in CTS patients, the MUNE technique is more accurate than a standard motor nerve conduction study (NCS). It was emphasized that MUNE evaluation in determining MU loss in the early stages of CTS may be helpful in diagnosis and treatment. There was no correlation between handedness and the number of MUs as determined by MUNE techniques. Both methods almost equally identify MU loss and have the same sensitivity and specificity.

The role of artificial intelligence in electrodiagnostic and neuromuscular medicine: Current state and future directions.

The rapid advancements in artificial intelligence (AI), including machine learning (ML), and deep learning (DL) have ushered in a new era of technological breakthroughs in healthcare. These technologies are revolutionizing the way we utilize medical data, enabling improved disease classification, more precise diagnoses, better treatment selection, therapeutic monitoring, and highly accurate prognostication. Different ML and DL models have been used to distinguish between electromyography signals in normal individuals and those with amyotrophic lateral sclerosis and myopathy, with accuracy ranging from 67% to 99.5%. DL models have also been successfully applied in neuromuscular ultrasound, with the use of segmentation techniques achieving diagnostic accuracy of at least 90% for nerve entrapment disorders, and 87% for inflammatory myopathies. Other successful AI applications include prediction of treatment response, and prognostication including prediction of intensive care unit admissions for patients with myasthenia gravis. Despite these remarkable strides, significant knowledge, attitude, and practice gaps persist, including within the field of electrodiagnostic and neuromuscular medicine. In this narrative review, we highlight the fundamental principles of AI and draw parallels with the intricacies of human brain networks. Specifically, we explore the immense potential that AI holds for applications in electrodiagnostic studies, neuromuscular ultrasound, and other aspects of neuromuscular medicine. While there are exciting possibilities for the future, it is essential to acknowledge and understand the limitations of AI and take proactive steps to mitigate these challenges. This collective endeavor holds immense potential for the advancement of healthcare through the strategic and responsible integration of AI technologies.

Overuse of the psychoactive analgesics’ opioids and gabapentinoid drugs in patients having surgery for nerve entrapment disorders

Knowledge about risks for overuse of psychoactive analgesics in patients having primary surgery for carpal tunnel syndrome (CTS) or ulnar nerve entrapment (UNE), or both, is limited. We investigated if patients with those nerve entrapment disorders have a higher risk of overuse of psychoactive analgesics (i.e., opioids and gabapentinoid drugs) before, after, and both before and after surgery than observed in the general population after accounting for demographical and socioeconomic factors. Using a large record linkage database, we analysed 5,966,444 individuals (25–80 years), residing in Sweden December 31st, 2010–2014, of which 31,380 underwent surgery 2011–2013 for CTS, UNE, or both, applying logistic regression to estimate relative risk (RR) and 95% confidence interval (CI). Overall, overuse of the psychoactive analgesics was low in the general population. Compared to those individuals, unadjusted RR (95% CI) of overuse ranged in patients between 2.77 (2.57–3.00) with CTS after surgery and 6.21 (4.27–9.02) with both UNE and CTS after surgery. These risks were only slightly reduced after adjustment for demographical and socioeconomic factors. Patients undergoing surgery for CTS, UNE, or both, have a high risk of overuse of psychoactive analgesics before, after, and both before and after surgery.

Role of High-Resolution Ultrasonography in Evaluation of Ulnar Nerve Entrapment Disorder

Role of High-Resolution Ultrasonography in Evaluation of Ulnar Nerve Entrapment Disorder

Appropriateness of carpal tunnel syndrome management compared with the AAOS appropriate use criteria: A retrospective review across various specialties

PurposeCarpal tunnel syndrome (CTS) is a common peripheral nerve entrapment disorder among adults that causes upper-extremity disability. The American Academy of Orthopedic Surgeons (AAOS) developed an evidence-based appropriate use criteria (AUC) for the management of CTS. This study aimed to assess the appropriateness of our practice and the usability of the AUC through comparing the actual management provided at our institution with that recommended by the AUC. MethodsA retrospective review of the electronic medical records at our hospital was performed between 1 Jan 2016 and 31 Dec 2019. Data were collected by two authors independently. The collected data were input into the AUC application to determine the rate of the appropriateness of the treatments. Afterwards, the agreement between the actual treatment provided and the AUC recommendation was assessed. The primary outcome was the appropriateness rate. Descriptive statistics such as the mean, range and percentage were used to summarize the patients’ demographics and treatment options. ResultsThere were 127 patients (169 interventions), with a mean age of 50.18 years (range, 24–85 years). Most of the included patients were females, 78% (99). Obesity was the most frequent risk factor 64.5% (82), and bilateral wrist involvement was the most common presentation 58% (74). The overall appropriateness rate and agreement with the AUC recommendations among all interventions was 84%. A sub-analysis of carpal tunnel surgical release across different surgical specialities showed appropriateness rates of 88%, 89%, 54% in orthopaedic surgery, neurosurgery and plastic surgery teams, respectively (Chi2 19.54, P-Value 0.000613). ConclusionThis study demonstrated that most of the treatments provided at our institution were appropriate and in agreement with the AUC recommendations. Additionally, the AUC for carpal tunnel syndrome is a valuable and practical tool that can be applied in clinical settings. Level of evidenceRetrospective study, level IV.

Observed Errors in Upper Extremity Impairment Rating: Recognition and Prevention

Abstract Impairment evaluations not performed following processes defined in the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) will result in erroneous ratings. Common errors in impairment rating (IR) for upper extremity are frequently seen in physician IR reports and independent medical examination reports. Recognizing these errors can result in the prevention and management of these ratings. Common errors include rating impairment using the diagnosis-based approach for more than one diagnosis within a region and making incorrect assessments of motion loss, nerve injuries, entrapment disorders, and complex regional pain syndrome.

Differential Diagnosis between Spinal Degenerative Disorder and Peripheral Nerve Entrapment Disease

In the surgical treatment of spinal degenerative disorders, neural function improves to some extent upon successful neural decompression. However, we have witnessed cases with poor postoperative results. The causes include surgical procedure issues, such as insufficient decompression of neural tissues and overlooking sites to be decompressed, and neurological misdiagnosis of other causative lesions or multiple lesions. Here, as necessary knowledge for spine surgeons dealing with spinal cord degenerative disorders to prevent poor surgical results, we have discussed the differentiation of peripheral nerve entrapment neuropathy from spinal degenerative disorders. Specifically, we have focused on L5 radiculopathy or common peroneal nerve entrapment disorder and C8 radiculopathy or thoracic outlet syndrome or ulnar nerve entrapment neuropathy, which are difficult to distinguish, and have explained the difference in their neurological symptoms from an anatomical perspective. We have also described the differential diagnosis of drop fingers, which is one of the neurological symptoms, and have mentioned the possibility of diseases managed by neurologists, which neurosurgeons should know about.

A Study on Morphology of Suprascapular Notch with Specific Emphasis on Completely Ossified Superior Transverse Scapular Ligament

Abstract Background and Aim The superior border of scapula is marked by suprascapular notch which is bridged by suprascapular ligament. Beneath this ligament, passes the suprascapular nerve. Narrow notch and completely ossified superior transverse scapular ligament is one of the risk factors for suprascapular nerve entrapment. This study is done to study morphological variation of suprascapular notch. Knowledge of various types of suprascapular notch will help the clinician in early diagnosis and surgical treatment. Materials and Methods A total of 525 human scapulae of unknown age and sex were studied for morphology of suprascapular notch at the Department of Anatomy, GMERS medical college, Vadnagar and at B. J. Medical College, Ahmedabad. Photographs of various types of suprascapular notch were taken using digital camera and classified as per the Rengachary classification. Result In the present study, as per Rengachary classification, out of 525 scapulae, the most common is Type III (47.1%), least common is Type V (1.9%), and completely ossified superior transverse scapular ligament is Type VI (8.9%). Conclusion Knowledge of various types of suprascapular notch will help the physician in screening high-risk patients as well as diagnosis and treatment of suprascapular nerve entrapment disorder.

Ultrasound-guided quadrilateral space block for the diagnosis of quadrilateral syndrome.

Quadrilateral space syndrome (QSS) is a rare nerve entrapment disorder that occurs when the axillary nerve and posterior circumflex humeral artery (PCHA) become compressed in the quadrilateral space. QSS presents as vague posterolateral shoulder pain that is exacerbated upon the abduction and external rotation of the shoulder. Diagnosis of QSS is difficult because of the vague presentation of QSS. In addition, even though MRI and MR angiography can be used in QSS diagnosis, there is currently no “gold standard” diagnostic imaging studies for QSS. In this case report, we describe a novel ultrasound-guided technique for a diagnostic quadrilateral space block and present a case where the diagnostic block was used to diagnose QSS. We believe that a diagnostic block of the quadrilateral space is a useful adjunct in the evaluation of patients with suspected QSS, especially in cases where examination findings and other diagnostic modalities are indeterminate.

Intraoperative conjoined lumbosacral nerve roots associated with spondylolisthesis

Lumbosacral nerve roots anomalies may produce low back pain. These anomalies are reported to be a cause for failed back surgery. They are usually left undiagnosed, especially in endoscopic discectomy techniques. Any surgery for entrapment disorders, performed on a patient with undiagnosed lumbosacral nerve roots anomaly, may lead to serious neural injuries because of an improper surgical technique or decompression. In this report, we describe our experience with a case of L5-S1 spondylolisthesis and associated congenital lumbosacral nerve root anomalies discovered during the surgical intervention, and the difficulties raised by such a discovery. Careful examination of coronal and axial views obtained through high-quality Magnetic Resonance Imaging may lead to a proper diagnosis of this condition leading to an adequate surgical planning, minimizing the intraoperatory complications.

Osteopathic manipulative medicine for carpal tunnel syndrome.

Carpal tunnel syndrome (CTS) is 1 of the most common peripheral nerve entrapment disorders. Osteopathic manipulative medicine can be invaluable in diagnosing and managing CTS. Combined with a patient's history and a standard physical examination, an osteopathic structural examination can facilitate localizing the nerve entrapment, diagnosing CTS, and monitoring the disease process. Osteopathic manipulative treatment is noninvasive and can be used to supplement traditional CTS treatment methods. The authors also review the relevant anatomy involving CTS and the clinical efficacy of osteopathic manipulative medicine in the management of this disorder.

Challenges in the Management of Distal Arm Pain

Arm pain is a common cause of disability, demand for healthcare and lost work time. A recent population-based study found that approximately one in seven workingaged adults in England consulted their general practitioner with upper limb pain per annum [1]. Of these, 42% had pain in the distal arm and, at 12-month followup, nearly half were still in pain, with one in five reporting unremitting pain (never pain-free for as many as 7 consecutive days) [2]. Distal arm pain, defined as pain in the elbow, forearm, wrist or hand, may involve a number of specific pathologies, and also a variety of nonspecific syndromes. As with most musculoskeletal disorders, conditions of the distal arm have typically been categorized according to anatomical location and/or type of pathology, derived from clinical observation and practice. In many cases, validity and reliability for various diagnoses have not been established. Considerable uncertainty over classification and diagnosis has already been reported for upper limb disorders [3] and this is likely to be repeated in the distal arm. Hence, there is a variety of different diagnostic labels that may not be consistently applied between practitioners, nor have a valid pathophysiological basis. This is further confounded by the potential for referral of symptoms from other locations such as the thoracic/cervical spine or shoulder into the distal arm. Apart from the more generic terms such as muscle strain, joint sprain or contusion, that may arise as a result of soft tissue trauma, other diagnostic labels for the distal arm pain include (but are not confined to) tendonitis, tenosynovitis, epicondylitis (in various guises including Golfers’ or Tennis elbow), repetitive strain injury, bursitis, osteoarthritis, carpal tunnel syndrome and other nerve entrapment disorders. In general, the evidence regarding management of these conditions is poor [3] and most guidelines are based on expert recommendations rather than clinical trials. Typically, this is because few or no trials have been conducted, or the results of different trials have been contradictory, leaving clinicians with little to go on but their own experience, past practice and peer opinion. For example, the majority of the American College of Occupational and

Day-to-day variability of median nerve location within the carpal tunnel

Background Carpal tunnel syndrome is a commonly encountered entrapment disorder resulting from mechanical insult to the median nerve. Magnetic resonance imaging (MRI)-based investigations have documented typical locations of the median nerve within the carpal tunnel; however, it is unclear whether those locations are consistent within an individual on different days. Methods To determine the day-to-day variability of nerve location, 3.0 T MRI scans were acquired from six normal volunteers over multiple sessions on three different days. Half of the scans were acquired with the wrist in neutral flexion and the fingers extended, and the other half were acquired with the wrist in 35° of flexion and the fingers flexed. Prior to half of the scans (in both poses), subjects performed a preconditioning routine consisting of specified hand activities and several repetitions of wrist flexion/extension. The shape, orientation, location, and location radius of variability of the median nerve and three selected flexor tendons were determined for each subject and compared between days. Findings Two of the six subjects had substantial variability in nerve location when the wrist was in neutral, and four of the subjects had high variability in nerve position when the wrist was flexed. Nerve variability was typically larger than tendon variability. The preconditioning routine did not decrease nerve or tendon location variability in either the neutral or the flexed wrist positions. Interpretation The high mobility and potential for large variability in median nerve location within the carpal tunnel needs to be borne in mind when interpreting MR images of nerve location.

Carpal Tunnel Syndrome Associated with the Use of Aromatase Inhibitors in Breast Cancer

Aromatase inhibitors (AI) inhibit peripheral conversion of androgens to estradiol and are commonly used as hormonal therapy for postmenopausal women with hormone receptor–positive breast cancer in the metastatic and adjuvant settings. Joint-related symptoms, however, are seen in a significant proportion of patients. Carpal tunnel syndrome (CTS) is a common nerve entrapment disorder affecting the median nerve. We describe 6 patients with newly diagnosed CTS after initiation of adjuvant AI therapy. Aromatase inhibitors were discontinued in several patients secondary to this toxicity with some switching to tamoxifen and most subsequently experiencing relief of their symptoms. Potential pathophysiologic roles of hormonal manipulation with AIs and other risk factors that might contribute to CTS are discussed. Aromatase inhibitors might accentuate the occurrence of CTS and potentially other nerve entrapment syndromes, and a more systematic approach should be used to better understand the clinical significance and incidence of these symptoms.

“Triple Cross” of the Hypoglossal Nerve and its Microsurgical Impact to Entrapment Disorders

Cadaveric dissections were performed to review the intracranial and extracranial course of the hypoglossal nerve. The neurological significance of a newly defined "triple cross" of the hypoglossal nerve is discussed. 10 cadaveric heads (left and right; 20 sides) were dissected using microsurgical techniques. In the cisternal segment of hypoglossal nerve, the diameter of the rostral trunk amounted to 155-680 microm (mean 435 microm), and the caudal trunk to 210-820 microm (mean 482 microm). The roots formed three trunks in 20% of the hypoglossal nerves and two trunks in the rest. As a first cross, the anterior medullary segment of the vertebral artery crossed the hypoglossal nerve roots in 14 of 20 sides (70%). As a rare variation, the vertebral artery extended medial to the nerve (25%) or between its roots (5%). The second cross was found between the descendens hypoglossus and the occipital artery (75%), sternocleidomastoid artery and vein complex (15%) and external carotid artery (10%). The third cross was shown in the submandibular triangle between the lingual hypoglossus and its drainage vein; vena committans nervus hypoglossus. Throughout its way, the hypoglossal nerve passes over vascular structures in three crossing points which may serve as a probable cause of hypoglossal nerve entrapment disorders.

Restless hand symptoms in carpal tunnel syndrome

Carpal tunnel syndrome (CTS) is a nerve entrapment disorder, involving the median nerve when it passes the carpal tunnel at the wrist. Using a case-control methodology, 312 electrophysiologically confirmed CTS patients with mean age of 51.3+/-9.4 (27-74) years (81.7% women) and 100 controls with mean age of 50.4+/-9.2 (21-88) years (75% women) were examined utilising a questionnaire similar to the clinical diagnostic criteria of restless legs syndrome (RLS). Forty-four (14.1%) of the CTS patients have symptoms compatible with restless hand syndrome compared with none (0%) in the control group (p < 0.0001). The severity of CTS was not significantly associated with the motor restlessness. Our observations suggest that entrapment syndromes such as CTS can be associated with a form of restlessness in the hands, analogous to RLS.