SummaryFace anti‐spoofing has attracted many attentions in security applications, such as mobile payment and entrance guard. Until now, face anti‐spoofing technique is still a challenging task. Mainstream image‐based spoofing algorithms usually use global motion or texture information to distinguish whether an input face is live or fake. However, the performance of these methods are sensitive in light changes, or images acquired from different sensors. The main reason is that spoofed face image always has slight different texture in local areas, such as landmark or salient region of face. To this end, this paper proposes a novel multi‐patches feature extraction strategy to detect spoofing. First, a set of patches with specific combination scheme is selected to cover the face image. Second, features such as hand‐crafted Gray Level Co‐occurrence Matrix (GLCM), Local Binary Patterns (LBP), or deep features are extracted from these patches. Third, all features are combined as the global descriptor of the face image, then fed into an SVM classifier to verify the anti‐spoofing detection. Experimental results show that the proposed strategy can effectively enhance the performance, concerning with the accuracy of spoofed face detection in four widely used anti‐spoofing databases.