Experimental infection of sheep with melaphagosis leads to significant structural damage to the skin and its nerve fibers. Bloodsuckers are mechanically transferred through skin scratching to endothelial cells and tissue settled macrophages from places of microtrauma caused by the piercing- sucking apparatus of the carriers and the runes themselves. Proboscis parasites injure the skin, blood vessels, causing inflammation. A synchrony of local and generalized inflammatory processes is formed, which last for a long time due to the blood-sucking of ectoparasites. Periodic suction of blood is accompanied by injection of saliva and coxal fluid into the capillary, which contain the pathogen, anticoagulants and enzymes. At the site of injury, labrocyte degranulation occurs, a large number of inflammatory mediators are released: histamine, heparin, serotonin, which initiate an inflammatory reaction and pain syndrome. Re-irritation of skin receptors, afferent pathways leads to depletion of metabolites in the nerve fibers, and dystrophic processes develop. The protective reaction at the site of the entrance gate is accompanied by the simultaneous generalization of the recovery process after the treatment of sheep with mediatrin. In the skin, compensatory- adaptive changes are observed in the epithelial sheaths of the hair roots, in the sebaceous glands and the restoration of the structure of the endothelium of the blood capillaries. Significant destructive changes in the structure of collagen and elastic fibers remain in the reticular layer of the dermis. Labrocytes, with a large number of granules, testify to a decrease in the intensity of the inflammatory process in the skin of sheep.