<b>Objectives:</b> Self-hypnosis (SH) induces patients into a relaxed state that may include feelings of dissociation through deep breathing and guided imagery. Studies have shown that SH can reduce patient distress prior to surgery and postoperative pain and anxiety. We evaluated whether adding SH to our enhanced recovery after surgery (ERAS) pathway was feasible and if it could improve patient-reported pain and anxiety and further decrease opioid use. <b>Methods:</b> Patients scheduled for open gynecologic surgery were randomized to either standard ERAS care or ERAS + SH. The 20-minute, 3D, SH audio recording was based on a well-validated medical hypnosis script. Patients in the SH arm were asked to listen to the audio file at least twice before surgery, although they had access to use it ad-lib after consent. The feasibility endpoint was defined as 60% of patients listening to the entire SH audio file in the preoperative holding area. The primary effectiveness outcome was worst pain on POD 1 (24-hour recall) on a 0-10 scale, assessed with the MDASI-PeriOpGYN. Secondary outcomes included anxiety, quality of life, symptom burden, time to the first opioid, quality of recovery (QoR-15), and morphine equivalent daily dose (MEDD) on POD 0-3. Hypnotic suggestibility was assessed by the Tellegen Absorption scale. Expectations and manageability of postoperative symptoms were assessed by the Side-Effect Expectancy Questionnaire (SEEQ). Satisfaction with the SH experience was evaluated. Summary statistics, Fisher's exact test (categorical variables), and Wilcoxon rank-sum test (continuous variables) were utilized. <b>Results:</b> A total of 152 patients were randomized and 138 had surgery and were evaluable (ERAS: <i>n</i> = 67; ERAS+SH: <i>n</i> = 71) (Table 1). Incorporation of SH was considered feasible, with 77.5% of ERAS+SH patients able to listen to the entire SH audio file in the preoperative holding unit. The study was stopped early due to futility in achieving the primary effectiveness outcome (pain on POD1). There were no significant differences in the primary outcome of worst pain on POD 1 (ERAS: 6/10; ERAS+SH: 7/10) (p=.70). The median age was 61 years in the ERAS arm and 54 years in the ERAS+SH arm (Table 1 for demographics). There were no significant differences in ERAS compliance, anesthesia type, or length of stay. No significant differences between the groups were noted on expectations, perceived ability to manage postoperative symptoms or hypnotic suggestibility. Median scores on the five satisfaction questions were 8/10 or above. There were no differences in median preoperative anxiety scores between the arms (ERAS: 4, IQR: 1-6; ERAS+SH: 4, IQR: 3-7). In the ERAS+SH arm, anxiety scores decreased significantly after the SH intervention in the preoperative holding unit -2 points (IQR:-3,-1) to a median score of 2 (p<.001). There were no significant differences in median MEDD on POD 0-3 between the two arms (daily median MEDD ranged from 0-15) or time to the first opioid. The quality of recovery score on the day of discharge was not significantly different between groups (ERAS: 110, IQR: 92-127; ERAS+SH: 107, IQR: 88-121). <b>Conclusions:</b> Incorporating SH into an ERAS pathway was feasible with high levels of satisfaction. While the SH intervention led to a statistically and clinically significant decrease in self-reported anxiety levels preoperatively, there were no group differences in self-reported pain, quality of recovery, time to the first opioid, or hospital MEDD. Given the ease of accessing and listening to an audio file, this SH intervention can be easily integrated into perioperative care to decrease preoperative anxiety.
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