The research aims to examine the relationship between the quality of logistics activities and business efficiency in manufacturing enterprises in the Northern region of Vietnam. The study selects five component factors of logistics activities including Internal Logistics, Inbound Logistics, Outbound Logistics, Support Logistics, and Logistics Costs to assess the impact of these factors on the Logistics Operation Quality and Business Effective. Primary data is collected from survey results, with 173 valid questionnaires. The study employs a Structural Equation Modeling (SEM) approach, processing data using SPSS 24 and AMOS 24 software. The research findings indicate that factors related to well-organized logistics activities all have a positive influence on the quality of logistics activities. Among these factors, the quality of Inbound Logistics has the greatest impact on the quality of logistics activities. Additionally, the quality of logistics activities positively affects the business efficiency of enterprises. Managerial implications and future research directions are also discussed.