The Belt and Road Initiative is a major strategy proposed by the Chinese government to strengthen economic ties with countries along the route and promote mutually beneficial cooperation. As an important practice of the Belt and Road Initiative, Chinese enterprises' direct investment in countries along the route shows some general characteristics, while Chinese enterprises also face various problems such as high investment risks, cultural differences, and social responsibility issues in the process of direct investment. This paper aims to conduct in-depth research on these issues and propose corresponding countermeasures to promote the investment activities of Chinese enterprises in countries along the Belt and Road. First of all, risk management measures should be adopted, a comprehensive assessment of political, economic, cultural and other factors in countries along the Belt and Road, scientific and reasonable investment plans should be formulated, and the supervision and risk control of investment projects should be strengthened. Second, we should pay attention to technical cooperation and personnel training, improve the technological level of countries along the Belt and Road through technology transfer and technological innovation, and promote economic development and regional cooperation. In addition, we need to pay attention to the social responsibility awareness of enterprises in the process of direct investment, pay attention to environmental protection, etc., and establish a good corporate image and reputation, so as to promote the realization of the "Belt and Road" initiative and jointly promote economic development and prosperity. Finally, this paper concludes that in the face of many problems and challenges, Chinese enterprises need to have a high degree of strategic vision, cultural understanding and risk management capabilities, while focusing on innovation and development, and are committed to achieving mutual benefit and win-win results and achieving common prosperity.