With the continuous evolution of the global economic landscape and the increasingly fierce competition in the market, the resilience of the enterprise quality immune system has become increasingly important. As an important province in Northeast China, Liaoning Province has rich industrial resources and talent reserves. In recent years, with the country's attention to and support for the innovation and development of small and medium-sized enterprises, Liaoning's "specialized, special and new" enterprises have gradually emerged and become an important force to promote regional economic development. In-depth research on it will not only help to enhance the core competitiveness of enterprises, but also help promote the industrial upgrading and economic development of the entire region to adapt to the changing market demand and competitive environment. By consulting relevant books, periodicals, policy documents, etc., we can deeply understand the core competitiveness and market position of Liaoning's "specialized, special and new" enterprises. Through the study of the resilience of the quality immune system of enterprises, the advantages of enterprises in specific fields or technologies can be revealed, and the development potential and growth space of "specialized, special and new" enterprises in Liaoning can be evaluated, which help to promote the development of enterprises further.