Those in the physical sciences work to understand relationships among non-social entities and this may come at a cost to their understanding of social relationships. Alternatively, it could be that those in the physical sciences differ in how comfortable they feel in social situations. Prior research had been confined to looking at differences between particular subject majors (e.g., humanities) and physical sciences, leaving open the possibility that people choosing subjects like psychology or biology might differ on empathy. University students (N=404) majoring in humanities, social science, life science, or physical science completed the empathy quotient (EQ). Confirmatory factor analysis showed three-factors of the EQ, and these were used in multinomial logistic regression. Empathy differences made a unique contribution to explaining subject major choice. We found that greater levels of empathy predicted membership in social and life sciences, while lower levels of empathy predicted physical sciences enrollment.