Clinical image retrieval plays a pivotal role in modern healthcare for diagnostics and research, but prior research has grappled with the challenge of achieving high accuracy due to limited filtering techniques. The proposed method includes statistical distance measurements for similarity comparison and a machine learning technique for image filtering. Throughout this framework, the search area for similarity matching is reduced by first filtering away irrelevant images using the probabilistic outcomes of the Support Vector Machine (SVM) classification as class predictions of search and database images. Resizing is done as part of the preprocessing. Then, using Principal Component Analysis (PCA), the preprocessed data’s textural features, visual characteristics, and low-level features are extracted. The study also suggested an adaptive similarity matching method centered on a linear integration of feature-level similarities on the individual-level level. The precision and ranking order details of the most appropriate images retrieved and predicted by SVMs are considered when calculating the feature weights. The system continually alters weights for every distinctive search to generate beneficial outcomes. The supervised and unsupervised learning strategies are studied to link low-level global image features in the generated PCA-based Eigen Space using their high-level semantic and visual classifications to reduce the semantic gap and enhance retrieval effectiveness. The ground-truth database used in experiments has 1594 unique medical images with 3 different databases. Our method significantly improves the precision and recall rates in image retrieval tasks by combining sophisticated feature extraction, data-driven algorithms, and deep learning models. Research obtained an impressive accuracy of 0.99, demonstrating the effectiveness of our approach. This novel methodology addresses the limitations of prior research and provides a robust and reliable solution for clinicians and researchers in the medical field seeking to access and analyze relevant clinical images.