Agrochemical usage in Ghana's agriculture sector has become indispensable for enhancing crop yields and combating weed infestations. However, its extensive application raises concerns due to its adverse effects on soil fertility, human health, and biodiversity. This study examines the multifaceted impacts of agrochemicals in Ghana, emphasizing the need for sustainable agricultural practices to mitigate these challenges. Through an analysis of the effects on crop yield, soil fertility degradation, human health risks, and biodiversity loss, this research underscores the urgency of regulatory measures and the adoption of organic farming methods. The findings highlight the importance of balancing agricultural productivity with environmental and human health considerations to ensure long-term sustainability. Keywords: Agrochemicals, Crop Yield, Soil Fertility, Human Health, Biodiversity, Ghana, Sustainable Agriculture, Organic Farming