In this work, several MxOy-supported CuO-MnO2 (MxOy=Al2O3, CeO2, TiO2 and Y2O3) composite catalysts were synthesized by the co-impregnation method using copper and manganese acetates as precursors. The catalysts were characterized by N2 adsorption-desorption at 77K, XRD, FESEM, FT-IR and XPS techniques. Low-temperature CO oxidation performances of the catalysts were evaluated using a fixed-bed reactor system. Amongst the prepared catalysts, CuO-MnO2/CeO2 exhibited excellent CO oxidation activity, good working stability after about 1h of reaction tested and superior kinetics performances. The dual synergistic effects in CuO-MnO2 and CuO-CeO2 are associated with the enhanced CO oxidation process observed over CuO-MnO2/CeO2. The catalyst shows promise for removing CO from typical confined spaces such as onboard naval submarines, space-crafts and mine refuge chambers.